Project Summary:
The main goal of this research project is to develop a new line of new stereotaxic devices for small animal
research that outperforms existing devices in terms of accuracy, reproducibility, and ease of use.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Eliminating the human factor from stereotaxic surgeries
Investigator
Achim Klug
Institute
popneuron llc
Fiscal Year
Funding Opportunities Number
Project Number
Title
Engineering of organoid-based brain circuits
Investigator
Andre Levchenko, Flora M Vaccarino
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
The human induced pluripotent stem cell (hiPSC) technology promises major advances in disease modeling
and personalized medicine.
Title
Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse Brains
Investigator
James C Gee, Yongsoo Kim, Lydia Lup-Ming Ng
Institute
pennsylvania state univ hershey med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Brain development is characterized by a diverse set of cell types that are born and connected into rapidly growing
complex 3D structures across time.
Title
Ethics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
Title
From ion channels to graph theory in sensorimotor learning
Investigator
Genevieve Konopka, Daniel Margoliash, Jason Neil Maclean, Todd F Roberts
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of
individuals is an overarching goal of neuroscience.
Title
Functional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning
Investigator
Shogo Ohmae
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum performs information processing for motor control and various cognitive functions in
cooperation with the cerebral neocortex.
Title
Generation of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system
Investigator
Seth Blackshaw
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
New tools are urgently needed to selectively target constructs that monitor and manipulate the activity of
individual cell types without having to rely on genetic manipulation.
Title
Genetic access and connectional assays of mouse inhibitory cortical cell types
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
Title
Genetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
Title
Genetic mechanisms specifying astrocyte functional diversity and their role in sleep
Investigator
Margaret Ho
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Astrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our
understanding of their identities and functions is far less comprehensive than for neurons.
Title
Graspy: A python package for rigorous statistical analysis of populations of attributed connectomes
Investigator
Carey Priebe, Joshua T Vogelstein
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Overview: We will extend and develop implementations of foundational methods for analyzing populations of
attributed connectomes.
Title
High throughput assaying of circuit activity and connectivity in brain organoids
Investigator
Paola Arlotta, Edward S. Boyden, Jennifer A. Lewis
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Experimental models of the human developing brain are needed to investigate human-specific aspects of
brain development, evolution, and neurological disease.
Title
High-throughput approaches to local and long-range synaptic connectivity
Investigator
Edward S. Boyden, Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The overarching objective of this proposal is to develop a robust approach to map the brain's connections
quickly, accurately, and cost-effectively.
Title
Highly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations
Investigator
Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national
Working Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and
generate evidence-based consensus recommendations for the ethical conduct
Title
Hormonal regulation of value-based decision-making
Investigator
Carla Golden
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Individuals decide between alternatives based on their perceived value of the reward associated with each
option.
Title
How do parvalbumin interneuron-generated gamma oscillations organize prefrontal networks to promote behavioral adaptation?
Investigator
Vikaas Singh Sohal
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Rhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many
cases these oscillations are synchronized across brain regions.
Title
Identifying mediators of sex hormone uptake and signaling
Investigator
Nicole Yishi Leung
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Sex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes
across our lifespan.
Title
Improving Brain Organoid Models by Mediating Metabolic Dysregulation
Investigator
Madeline Andrews
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is currently an unmet need for accurate model systems of the human brain to study its cellular and
molecular features.
Title
Innovative biostatistical approaches to network level analyses of connectome-behavior relationships
Investigator
Muriah D Wheelock
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Determining the mechanisms by which the human brain generates cognition, perception, and emotion hinges
upon quantifying the relationships between coordinated brain activity and behavior.
Title
Integrative labeling, imaging, and reconstruction tools for high-throughput inhibitory microconnectivity analysis in the mouse brain
Investigator
Dawen Cai, Yan Yan
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Neural circuits composed of interconnected neurons with distinct properties lay the physical foundation
of any brain function. Identifying connections between individual neurons is central to understand how
information is processed and propagated in the brain.