SUMMARY ABSTRACT
More than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000
new cases.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleInter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury
Investigator
Claudia Angeli, Maxwell Boakye
Institute
university of louisville
Fiscal Year
Funding Opportunities Number
Project Number
TitleInvestigation of the Cortical Communication (CORTICOM) System
Investigator
Nathan E Crone, Nicolas Franciscus Ramsey
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
For many years brain-computer interfaces (BCI's) have been explored as a means of restoring communication
to patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which
cognition is intact but nearly all motor output from the brain is interrupted, eff
TitleLarge-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex
Investigator
Jordan Marie Ross
Institute
georgia state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still
maintaining the ability to detect change in the environment is critical to biological success.
TitleLarge-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and Attention
Investigator
Tirin Moore, Krishna V Shenoy, Joni D Wallis
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Prefrontal cortex (PFC) is critical for a range of high-level cognitive functions, such as attention and decision-
making. Studying these processes is difficult, since they are covert, dynamic and under the control of the
subject, rather than the experimenter.
TitleLateral habenula circuit in reward/conflict mediation
Investigator
Christian Emmanuell Bravo-Rivera
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Reward is often present in risky environments, requiring individuals to weigh the benefits of rewards against
the associated risks. There are several psychiatric disorders in which patients are unable to choose an
appropriate response during risky reward opportunities.
TitleLinking Hippocampal Replay Content to Learning and Decision-Making
Investigator
Michael Edward Coulter
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Memory is an integral component of human cognition, and when memory processes go awry, the result is
devastating neurological disorders of memory loss including Alzheimer's disease and other forms of dementia.
One essential role of normal memory processes is to use previou
TitleLinking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampus
Investigator
Sara J Aton
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project summary: Synaptic plasticity in brain structures like the hippocampus has been hypothesized to
underlie an essential brain function - consolidating transient experiences into long-lasting memories.
TitleLinking molecular and anatomical features of brain cell identity through computational data integration
Investigator
Joshua Welch
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Linking molecular and anatomical features of brain cell identity through computational data integration
Abstract
The brain contains diverse cell types that vary widely in characteristic properties and function in complex,
interconnected circuits.
TitleMapping human brain perivascular space in lifespan using human connectome project data
Investigator
Jeiran Choupan
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Perivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble
waste.
TitleMapping the neural circuitry underlying walking
Investigator
Sumaira Zamurrad
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Walking is an essential and conserved behavior across the animal kingdom.
TitleMarkerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
Investigator
Kyle Scott Severson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this proposed research is to reveal the sensory origins underlying the body schema
representation. Body schema is the brain's internal model of the body's spatial configuration.
TitleMassively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
Investigator
Danny Jj Wang, Lihong Wang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT (30 Lines)
The BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation
noninvasive human brain imaging tools and methods that will lead to transformative advances in our
understanding of the human brain.
TitleMeasuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan
Investigator
Elizabeth Johnson
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Memory is core to human cognition, undergoes protracted developmental maturation and age-related decline,
and is disrupted in numerous neurological and neuropsychiatric disorders.
TitleMetastable dynamics in cortical circuits
Investigator
Braden Brinkman, Alfredo Fontanini, Giancarlo La Camera, Arianna Maffei, Il Memming Park, Jin Wang
Institute
state university new york stony brook
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Cortical circuits generate dynamic patterns of activity. One of the great challenges of modern neuroscience is to
determine the circuit architectures that generate such dynamics patterns, and understand their genesis and functional
significance.
TitleModeling developmental gradients and supportive tissue signaling networks using iPSC-derived forebrain organoids embedded in fluidic hydrogels
Investigator
Leon Marcel Bellan, Vivian Gama
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding of many aspects of the human brain is currently limited due to the lack of appropriate model
systems that recapitulate the heterogenous nature of the human brain and the ethical and practical limitations
of working with human brain tissue from patients.
TitleMolecular Multi-Species Approach for Trans-Synaptic Labeling of Neural Circuits
Investigator
Gilad Barnea, Marnie E Halpern, Jennifer Mengbo Li, Drew Robson
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
It is estimated that the human brain contains an overwhelming 1015 synapses, structures essential for the normal
functioning of neural circuits.
TitleMultimodal study of infra-slow propagating brain activity
Investigator
Xiao Liu
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The highly-organized intrinsic brain activity, as measured by resting-state functional magnetic resonance imaging
(rsfMRI), is being widely used to measure functional brain connectivity in both healthy subjects and patient
groups, despite the underlying neural mechanisms remain large
TitleMultiplexed Nanoscale Protein Mapping Through Expansion Microscopy and Immuno-SABER
Investigator
Edward S. Boyden, Peng Yin
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Tools for surveying brain cell types and circuits must be scalable, both in the number of molecular targets
visualizable at once, and in the size of the tissues that can be assessed.
TitleMultiplexing working memory and timing: Encoding retrospective and prospective information in transient neural trajectories.
Investigator
Dean V Buonomano, Peyman Golshani
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
A general principle of brain function is the ability to store information about the past to better predict and prepare for the
future.
TitleMultiscale imaging of marmoset cortex during visual object recognition and learning
Investigator
Elias Issa
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY/ABSTRACT
Anthropoid primates (monkeys, apes, and humans) are distinguished from their phylogenetically nearest
relatives (lemurs, tree shrews, and rodents) by an elaboration of the cerebral cortex including changes in
cellular composition of the cortical circuit.