The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their
integrated into neuroscience research practice.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA Technology Resource for Polymer Microelectrode Arrays
Investigator
Ellis Meng, Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
TitleA wearable functional-brain-imaging system with full-head coverage and enhanced spatiotemporal-resolution to study complex neural circuits in human subjects
Investigator
Peter D. D. Schwindt
Institute
sandia corp-sandia national laboratories
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
To develop maps at multiple scales of neuronal circuits in the human brain and study the brain dynamics, there
is a need for non-invasive functional brain imaging with high spatiotemporal resolution operating in natural
environments.
TitleA wearable high-density MEG system with uOPMs
Investigator
Orang Alem
Institute
fieldline, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This Phase I project will focus on developing key elements needed to achieve a wearable, high-density,
magnetoencephalography (MEG) device based on optically-pumped atomic magnetometers (OPMs).
OPM sensors have progressed to be comparable in sensitivity to liquid-helium-cooled superconducti
TitleAccessible technologies for high-throughput, whole-brain reconstructions of molecularly characterized mammalian neurons
Investigator
Michael I Miller, Ulrich Mueller
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The BRAIN Initiative seeks to accelerate the development and application of innovative technologies that
ultimately will revolutionize our understanding of the human brain.
TitleAccurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation
Investigator
Luis Javier Gomez
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Transcranial magnetic stimulation (TMS) is a noninvasive technique used for neuroscience research and
treatment of psychiatric and neurological disorders. During TMS, a current-carrying coil placed on the scalp
induces an electric field that modulates targeted neuronal circuits.
TitleAcoustically targeted molecular control of cell type specific neural circuits in non-human primates
Investigator
Mikhail Shapiro, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Controlling specific neural circuits across large areas of the brain is a major technology goal of the BRAIN
Initiative.
TitleADVANCED NEXT GEENRATION RADIO FREQUENCY COILS FOR MAGNETIC RESONANCE IMAGING
Investigator
Ravi Srinivasan
Institute
advanced imaging research, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Magnetic resonance imaging (MRI) is a safe, non-ionizing diagnostic tool. The overall goal of this
project is to arrive very close to the ultimate intrinsic signal to noise ratio (UISNR) for a given MRI
magnet field strength by combining innovations in very advanced transceiver technology.
TitleAn open software solution to integrate non-invasive brain stimulation with functional imaging data
Investigator
Alexander Opitz
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Noninvasive tools capable of selectively manipulating neural systems in the human brain are needed to
advance our neuroscientific understanding of brain function and develop novel non-pharmacologic
psychotherapeutics and are a major focus of Brain Initiative funding.
TitleAn optogenetic brain implant with EEG monitoring and response for mice
Investigator
Kevan Sayed Hashemi
Institute
open source instruments, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Optogenetics can be used to selectively stimulate or suppress the firing of genetically
targeted and spatially targeted mammalian neurons. It is used to study neuropsychiatric
diseases in vivo with mouse models of conditions including epilepsy, schizophrenia, and
Parkinson's.
TitleAutomating whole brain connectomics: development, validation, and application of an open toolkit
Investigator
Davi Bock
Institute
university of vermont & st agric college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
We have recently published a 3D electron microscopy volume of the whole fruit fly brain. However mapping of
synaptic `wiring diagrams' or connectomes of neuronal circuits from this volume is currently completely manual
and therefore slow.
TitleAxonal connectomics: dense mapping of projection patterns between cortical areas
Investigator
R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Connectomics is a new field, created with the goal of densely or completely mapping the connections in the
brain. Because this goal is at present only achievable for small organisms, connectomics has taken on two forms
in the study of larger brains.
TitleBCI2000: Software Resource for Adaptive Neurotechnology Research
Investigator
Peter Brunner, Gerwin Schalk
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
The central nervous system (CNS) changes throughout life, and its interactions with the world produce activity-
dependent plasticity that enables it to acquire and maintain useful behaviors.
TitleBilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic Feedback
Investigator
Helen Bronte-Stewart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Gait impairment and Freezing of gait (FOG), lead to falls, injury (even death), loss of independent living, and are
common in neurodegenerative diseases such as Parkinson’s Disease (PD), affecting over 7 million people
worldwide.
TitleBRAIN INITIATIVE RESOURCE: DEVELOPMENT OF A HUMAN NEUROELECTROMAGNETIC DATA ARCHIVE AND TOOLS RESOURCE (NEMAR)
Investigator
Amitava Majumdar, Scott Makeig, Russell A Poldrack, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
To take advantage of recent and ongoing advances in intensive and large-scale computational methods,
and to preserve the scientific data created by publicly funded research projects, data archives must be
created as well as standards for specifying, identifying, and annotating deposited data.
TitleBridging structure, dynamics, and information processing in brain networks
Investigator
Hannah Choi
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
The mammalian brain is believed to be optimally designed for robust and adaptable computation of the
sensory inputs from the world, with respect to both its hardware (network structure) and software (network
dynamics).
TitleBuilding a Complete, Predictive, Data-Driven Model of Action Selection During Olfactory Navigation
Investigator
Matthieu R. P. J. C. G. Louis
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
To survive, living organisms must collect information about their environment and use it to select appropriate
behaviors. However, information from the environment is often noisy, incomplete and ambiguous.
TitleCanonical computations for motor learning by the cerebellar cortex micro-circuit
Investigator
Nicolas Brunel, Court A Hull, Stephen G Lisberger, Javier F Medina
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The cerebellum is critical for learning and executing coordinated, well-timed movements. The cerebellar
cortex seems to have a particular role in learning to time movements.
TitleCell class- or type-specific viruses for brain-wide labeling and neural circuit examination
Investigator
Bosiljka Tasic
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Experimental access to specific cell classes or types in the brain is essential for elucidating their roles in neural
circuit function.
TitleCell-Specific Visualization of Endogenous Proteins
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A major goal of the BRAIN initiative is to understand neuronal connectivity and plasticity in the context of
animal behavior. The functions and connectivity of neurons are established and manifested by their constituent
proteins. Monitoring the organization of individual proteins
TitleChromatin Plasticity, Transcriptional Activity and Kinetics in Developing and Adult Human Astrocyte and Oligodendroglial Lineages
Investigator
Nadejda Mincheva Tsankova
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Summary
While glial research has advanced in rodent models, significantly less progress has been made in
understanding human-specific diversity of glia at a molecular and a functional level, both during development
and in adulthood.