ABSTRACT
The overarching goal of this project is to secure, link, and disseminate BRAIN Initiative data, including
electrophysiology, imaging, behavioral, and clinical data with all pertinent recording and imaging parameters,
coming from participating sites.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Data Archive for the Brain Initiative (DABI)
Investigator
Dominique Duncan, Nader Pouratian, Arthur W Toga
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Title
Data interface and apps for systems neurophysiology and imaging
Investigator
Stephen D Van Hooser
Institute
brandeis university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Technology for recording from the brain is developing at a breakneck pace.
Title
DELINEATING CELL-SPECIFIC OUTPUT PATHWAYS OF THE GPe THAT SUPPORT LONG-LASTING BEHAVIORAL RECOVERY IN DOPAMINE DEPLETED MICE
Investigator
Aryn Hilary Gittis
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
A major challenge in the treatment of neurological diseases is the elaborate and diffuse nature of neural
circuits, where physically proximal neurons are engaged&
Title
Dendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neurons
Investigator
Hong-Wei Dong, Xiangdong William Yang
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Integrating molecular, morphological, and connectomic properties is critical for unbiased
classification of neuronal cell types in the mammalian brain.
Title
Designing low-cost, customizable high-density probes for acute and chronic neural recordings in rodents
Investigator
Ingrid Van Welie
Institute
neural dynamics technologies inc.
Fiscal Year
Funding Opportunities Number
Project Number
SF424 – Project Summary
Understanding how the brain generates certain behaviors requires an understanding of
the function of individual neurons in dynamical neural circuits.
Title
Development of a Revolutionary MRI System for Functional Brain Imaging
Investigator
Bob S Wagner, Sou-Tien Bert Wang
Institute
wang nmr, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
It is the dream of researcher's and clinician's to have available a low cost, portable MRI scanner for brain
neuroimaging. However, such a low cost MRI system requires a small bore MRI magnet.
Title
Development of predictive coding networks for spatial navigation
Investigator
George Dragoi
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Development of predictive coding networks for spatial navigation
Summary: Mammalian navigation uses internal models to predict the spatial-temporal statistical regularity of
the sequence of environmental locations.
Title
Dissecting corticostriatal circuitry underlying chronic binge eating
Investigator
Britny Hildebrandt
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Eating disorders are severe psychiatric conditions with a significant worldwide cost and disability burden. Binge
eating (BE) is a behavior that cuts across nearly all eating disorder diagnoses.
Title
Dual-channel Sub-millisecond Resolution Neural Imaging System
Investigator
Youbo Zhao
Institute
physical sciences, inc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The investigation of the complex neural dynamics and the cognitive functions of the brain requires non-
invasive recording tools with high spatio-temporal resolution.
Title
Early Feasibility Clinical Trial of a Visual Cortical Prosthesis
Investigator
Jessy D Dorn, Robert Jay Greenberg, Nader Pouratian
Institute
second sight medical products, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Blindness in the United States is a large and increasing problem. Any significant vision loss is
debilitating, but profound blindness is devastating to an individual’s ability to be independent
and to perform everyday tasks and activities.
Title
Elucidating the Wiring and Rewiring of Poly-synaptic Memory Circuits by Directed Stepwise Trans-neuronal Tracing
Investigator
Wei Xu
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Multimodal sensory information is converged through poly-synaptic pathways to the
hippocampus to form integrated representations and encode memories of the world, which in
turn guide our future behavior through multiple poly-synaptic downstream pathways.
Title
Epigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cells
Investigator
Andrew Adey
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The mammalian brain is an enormously complex organ with myriad cell types cohesively working together to
carry out a host of intricate tasks, from motor functions, to the storing and execution of consciousness.
Title
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATION
Investigator
Hong Chen
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Although neurotechnologies are rapidly advancing, we lack a noninvasive, cell-type specific, and
spatiotemporally regulated neuromodulation tool, which would radically change neuroscience research and
enable clinically noninvasive brain stimulation with high spatiotemporal p
Title
From Electron Microscopy to Neural Circuit Hypotheses: Bridging the Gap
Investigator
Michale S Fee
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
From Electron Microscopy to Neural Circuit Hypotheses: Bridging the gap
Recent advances in experimental technology promise rapid progress in developing a mechanistic
understanding of how neural circuit structure, at the synaptic scale, leads to complex sensory,
cognitive, and motor behaviors.
Title
High SNR Functional Brain Imaging using Oscillating Steady State MRI
Investigator
Douglas C Noll
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: High SNR Functional Brain Imaging using Oscillating Steady State MRI
Functional brain imaging using MRI (functional MRI or fMRI) has grown rapidly over the past 25 years and is
widely used for basic cognitive neuroscience research and for presurgical planning.
Title
Human Agency and Brain-Computer Interfaces: Understanding users’ experiences and developing a tool for improved consent
Investigator
Sara Goering, Eran Klein
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neural prosthetic devices for sensorimotor and psychiatric disorders are in development as a
priority area of the BRAIN Initiative yet they raise important ethical concerns about human
agency.
Title
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
Investigator
Lisa Stowers
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
How does the brain transform sensory information into complex behavior?
Title
Illuminating Neurodevelopment through Integrated Analysis and Vizualization of Multi-Omic Data
Investigator
Ronna Hertzano, Owen R White
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The wealth, depth and quality of multi-omic data generated through funding from the BRAIN
initiative is unprecedented. It ranges from bulk and single cell RNA-seq, to detailed cell type-
specific epigenetic analyses throughout development.
Title
Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain
Investigator
David A Boas, Bruce Fischl
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Title
In Vivo Imaging of Local Synaptic Neuromodulation by Dopamine
Investigator
Paul Robert Evans
Institute
max planck florida corporation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Dopamine (DA) is a powerful neuromodulator that facilitates memory formation and underlies reward-related
behaviors by regulating synaptic plasticity.