PROJECT SUMMARY/ABSTRACT
New technologies that modulate brain function have tremendous potential for alleviating the persistent burden
of depression and other neuropsychiatric disorders, but also raise challenging ethical and societal questions
regarding self-ownership and control over our thoughts,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleAchieving ethical integration in the development of novel neurotechnologies
Investigator
Winston Chiong
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TitleAn anatomical cell type atlas of gene expression, morphology and connectivity
Investigator
Hongkui Zeng
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Research Segment 2)
The brain circuit is an intricately interconnected network of numerous cell types.
TitleAnatomical characterization of neuronal cell types of the mouse brain
Investigator
Giorgio A Ascoli, Hong-Wei Dong, Byungkook Lim
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY AND ABSTRACT
A comprehensive understanding neuronal cell type diversity is an essential guide to selective manipulation and
illuminating cell type specific functional contributions toward health and disease.
TitleAnatomy
Investigator
Z Josh Huang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
ANATOMY RESEARCH SEGMENT SUMMARY
The overarching goal of neuroanatomy is to establish a structural framework to integrate multiscale and
multi-modal information and to provide a road map that guides the exploration of neural dynamics and brain
function. “Anatomic” neuron types
TitleBIDS-Derivatives: A data standard for derived data and models in the BRAIN Initiative
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The effective sharing of data requires the development and broad adoption of standards for the
organization of data and metadata.
TitleBrain circuit mapping using light inducible recombinase systems
Investigator
Ali Haydar Cetin
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mammalian brain is composed of vast numbers of intricately interconnected neurons with various
molecular, anatomical and physiological identities.
TitleCenter for Epigenomics of the Mouse Brain Atlas (CEMBA)
Investigator
Edward M Callaway, Joseph R Ecker
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
OVERVIEW: Project Summary
A comprehensive understanding of how neural circuits spanning the entire brain generate the full repertoire of
perception and behaviors requires a list of brain cell types, as well the means to target each cell type in order
to interrogate the functional interactions that g
TitleCerebellar network mapping with a high-throughput TEM platform
Investigator
Wei-Chung Allen Lee
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fundamental goal in neuroscience is to understand how information is processed in neuronal circuits.
Ultimately, we would like to understand the relationship between circuit structure and network function.
However, the immense complexity of most brain networks has been a s
TitleCircuit mechanisms of evidence accumulation during decision-making
Investigator
Zhihao Luo
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Circuit mechanisms underlying evidence accumulation during decision-making
Behavior across many types of decision-making is well described by the gradual accumulation of evidence
toward one of multiple alternatives.
TitleCollaboratory for atlasing cell type anatomy in the female and male mouse brain
Investigator
Pavel Osten
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Even though scientists have been captivated by the diversity of brain cells for well over a century, since the
initial anatomical descriptions by Santiago Ramón y Cajal, it is only recently that the developments in new
technologies allowed us to truly appreciate the astonishing complexity of cell ty
TitleComputational and circuit mechanisms underlying motor control
Investigator
Rui M. Costa
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Understanding the mechanisms that the nervous system uses to control movement is critical for
understanding brain and behavior, and one of the fundamental questions in neuroscience.
TitleDeep brain stimulation for depression using directional current steering an individualized network targeting
Investigator
Wayne K Goodman, Nader Pouratian, Sameer Anil Sheth
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain
stimulation (DBS) that have, unfortunately, produced inconsistent outcomes.
TitleDevelop and validate novel chemogenetic tools to modulate synaptic transmission
Investigator
Susumu Tomita
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Neural circuits encode animal behaviors, and neuroplasticity induces long-lasting
changes in neural circuits and animal behaviors. Neural circuits are formed by billions of
neurons, which communicate mostly through synapses.
TitleDevelopment of Line-Scan Temporal Focusing for fast structural imaging of synapse assembly/disassembly in vivo
Investigator
Josiah R Boivin
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
A disproportionately large number of mutations resulting in neurodevelopmental and neuropsychiatric
disorders target synaptic proteins. Synapse remodeling and loss precede cell death in neurodegenerative
disorders, and addictive drugs can alter circuit connectivity.
TitleDevelopment of tools for cell-type specific labeling of human and mouse neocortical neurons
Investigator
Ed Lein, Boaz Pirie Levi, Jonathan T Ting
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How the brain performs its computational task is a great unsolved problem in biology, but this answer is vital
for us to understand and combat disorders of brain function like autism, schizophrenia, and Alzheimer’s.
One appealing strategy towards solving this problem is to deconstruc
TitleElectrophysiological Biomarkers to Optimize DBS for Depression
Investigator
Helen S Mayberg
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) white matter is an emerging new treatment
strategy for treatment resistant depression (TRD) with published studies demonstrating sustained long-term
antidepressant effects in 40-60% of implanted patients.
TitleElectrophysiological source imaging guided transcranial focused ultrasound
Investigator
Bin He
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We propose to develop and test a novel noninvasive neuromodulation technique integrating transcranial
focused ultrasound (tFUS) with electrophysiological source imaging (ESI) to allow real-time evidence-based
neuromodulation with spatio-temporal precision for brain research and manag
TitleElementary Neuronal Ensembles to Whole Brain Networks: Ultrahigh Resolution Imaging of Function and Connectivity in Humans
Investigator
Kamil Ugurbil
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT:
The strategic plan of the NIH's BRAIN Initiative (BRAIN 2025: A scientific Vision) calls for transformative
technological developments with MRI to achieve “submillimeter spatial resolution descriptions of neuronal
activity, functional and structural connectivity, and network analysis in t
TitleEnabling ethical participation in innovative neuroscience on mental illness and addiction: towards a new screening tool enhancing informed consent for transformative research on the human brain
Investigator
Laura W Roberts
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Great discoveries in neuroscience hold promise for reducing the burden of many of the most disabling
conditions that threaten human health on a global scale, including mental illnesses and addictions.
Increasingly, exceptionally innovative science inspires hope that these devastating brain-based dis
TitleEnabling Shared Analysis and Processing of Large Neurophysiology Data
Investigator
William J Schroeder
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Understanding brain function is key to improving health care and advancing a number of scientific initiatives.
The treatment of degenerative brain diseases such as Alzheimer's, Parkinson’s, and ALS is becoming
increasingly important as the current US population ages and li