Funded Awards

PROJECT SUMMARY Within every brain region, neurons can be classified into dozens or hundreds of different cell types, each with unique functional roles and unique impacts on disease states.

SUMMARY The "NexGen" 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.

This Phase II project describes the commercial development of HyperAxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional

Project Summary/Abstract: The field of optogenetics — utilizing light to engage biological systems — is widely used for the dissection of neural circuits, cellular signaling and manipulating neurophysiological systems in awake, behaving animals.

Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.

Project Summary/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.

Electrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.

Project Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various ‘non-social’ aspects of internal state and physiological processes.

Project Summary/Abstract This project will provide a more nuanced and mechanistic model of the role of sleep in memory consolidation, particularly as it pertains to procedural motor skill acquisition in a non-human primate model.

PROJECT SUMMARY Survival in dynamic environments demands that behaviors are flexible and adaptive. An organism must make predictions about which actions lead to rewards, calculate how outcomes differ from those predictions (prediction errors), and adapt a behavioral strategy accordingly.

Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI

PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.

Abstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.

Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.

PROJECT SUMMARY / ABSTRACT. Research Project: Spatial memory – memory of where an event happened or an object was located – depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.

Abstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.

PROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.

PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.

Over the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.

Project Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.