7. Project Summary/Abstract
Opioid receptors (ORs), consisting of -, -, and -ORs, are neuropeptide receptors that are broadly involved
in regulating analgesia, mood, reward, and motor coordination.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleEngineering optogenetic tools for studying neuropeptide activity
Investigator
Alexander Robert French
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
TitleEthical Safeguards for Exit and Withdrawal from Implanted Neurotechnology Research
Investigator
Lauren Sankary
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Research participants face complex decisions about the surgical removal of implanted devices
upon exiting clinical trials of implanted neurotechnology.
TitleEthics of Patients and Care Partners Perspectives on Personality Change in Parkinsons disease and Deep Brain Stimulation
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
In our work with patients with neurological disorders, we often encounter patients and families who are afraid.
They are afraid that due to their neurodegenerative disorder or potential treatment, such as neurosurgery, they
will cease to exist – they will no longer be who they “are”.
TitleFrom microscale structure to population coding of normal and learned behavior
Investigator
Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This study aims to understand how the ensemble activity and network architecture of a neuronal population
guides natural and learned behavior.
TitleGenetic analyses of complete circuit formation in Caenorhabditis elegans
Investigator
Steven Jay Cook
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Despite the central importance of neural circuit development to brain function and behavior, we lack the genetic
information required to assemble a complete circuit.
TitleHigh Throughput Approaches for Cell-Specific Synapse Characterization
Investigator
Alison L Barth, Marcel P Bruchez
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT DESCRIPTION
Synapses are formed, broken and reformed dynamically both during development, normal
function and in response to activity.
TitleHigh throughput mapping of neuronal circuitry using DNA sequencing
Investigator
Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The long-term goal of these investigations is to develop methods based on high-
throughput DNA sequencing for determining neuronal circuitry. Neurons transmit
information to distant brain regions via long-range axonal projections.
TitleImaging Human Brain Function with Minimal Mobility Restrictions
Investigator
Michael Garwood
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Magnetic resonance imaging (MRI), by offering the sole means of imaging human brain
structure and activity with high spatial resolution, has evolved into an indispensable tool for
studying brain function in health and disease.
TitleImpact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates
Investigator
Marc A Sommer
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive methods for stimulating the human brain show great promise for safe, effective treatments of
psychiatric and motor disorders, and are in widespread use for basic research on human behavior and
cognition.
TitleIntegrative approach to classifying neuronal cell types of the mouse hippocampus
Investigator
Hong-Wei Dong, Li I Zhang
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Identifying the diversity of cell types in the nervous system will allow for their selective manipulation and reveal
their functional contributions in health and disease.
TitleInvestigating the Role of Neurotensin on Valence Assignment During Associative Learning in the Basolateral Amygdala
Investigator
Jacob Michael Olson
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Learned associations between environmental stimuli and organism-effecting outcomes guide adaptive
behavior. When healthy, this process results in increased rewards and decreased harm.
TitleLarge-scale monitoring of sensory transformations in the mammalian olfactory system
Investigator
Shawn Denver Burton
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How information is transformed as it propagates through a neural circuit remains an outstanding question of modern
neuroscience.
TitleLow cost, fully implantable wireless optoeletronic devices for optogenetics research
Investigator
Roozbeh Ghaffari
Institute
neurolux, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
The methods of optogenetics enable light-induced, area-confined stimulation or inhibition
of genetically targeted neurons, thereby bypassing key disadvantages of electrical approaches.
As a result, optogenetics is now widely viewed as an essential tool in neuroscience res
TitleMechanism and dosimetry exploration in transcranial electrical stimulation using magnetic resonance current mapping methods.
Investigator
Rosalind J Sadleir
Institute
arizona state university-tempe campus
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Transcranial electrical stimulation (tES) methods, principally transcranial direct current simulation
(tDCS) and transcranial alternating current stimulation (tACS) are neuromodulation techniques that
have been the subject of great recent interest.
TitleMechanisms of neural circuit dynamics in working memory anddecision-making
Investigator
Carlos D Brody, Mark S Goldman, Jonathan William Pillow, Hyunjune Sebastian Seung, David W Tank, Samuel Sheng-Hung Wang, Ilana Witten
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Working memory, the ability to temporarily hold multiple pieces of information in mind for manipulation, is
central to virtually all cognitive abilities.
TitleMRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER
Investigator
David Alan Feinberg, Chunlei Liu, Pratik Mukherjee, Kawin Setsompop, Lawrence L Wald
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The overarching objective of our proposal is to bring noninvasive human brain imaging into the microscale
(50-500 micron isotropic) resolution in order to create a tool for studies of neuronal circuitry and network
organization in the human brain.
TitleMulti-context software for robust and reproducible neuroscience image analysis
Investigator
Xenophon Papademetris, Dustin Scheinost
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Abstract)
The goal of this application is to develop, test, and disseminate multi-context (command line, desktop, server,
and web applications) software for robust and reproducible neuroscience image analysis from data across mul-
tiple scales (two photon microscopy, mesoscale Ca2+
TitleNano-switches for optogenetic control of neuronal proteins with ultra-specificity
Investigator
Lei Wang
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Summary/Abstract
The ability to control protein function with light provides excellent temporal and spatial resolution for precise
investigation in situ, and thus is having significant impact on neuroscience.
TitleNeuroethics of aDBS Systems Targeting Neuropsychiatric and Movement Disorders
Investigator
Wayne K Goodman, Gabriel Lazaro-Munoz, Amy L Mcguire
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Adaptive deep brain stimulation (aDBS) systems can record neural activity and adjust stimulation in real
time.
TitleNeuromodulatory control of collective circuit dynamics in C. elegans
Investigator
Steven Willem Flavell
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Many animal behaviors are organized into long-lasting states, perhaps most strikingly in the sleep/wake
and emotional states that mammals display. However, the fundamental mechanisms that allow animals to
initiate, maintain and terminate these states are unknown.