DESCRIPTION (provided by applicant): Monosynaptic tracing using rabies virus has become a standard component of the systems neuroscience toolkit, allowing identification and manipulation of neurons directly presynaptic to any targeted neuronal population in the brain.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Anterograde monosynaptic tracing
Investigator
Ian R Wickersham
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Title
Berkeley Course on Mining and Modeling of Neuroscience Data
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled "Mining and Modeling of Neuroscience Data" which is held at UC Berkeley.
Title
BRAIN Initiative: Integrated Multimodal Analysis of Cell and Circuit-Specific Processes in Hippocampal Function
Investigator
Jonathan V. Sweedler
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The BRAIN Initiative seeks to understand the spatial, temporal and chemical nature of the brain.
Title
Central thalamic stimulation for traumatic brain injury
Investigator
Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments.
Title
Computational and circuit mechanisms for information transmission in the brain
Investigator
Uri Tzvi Eden, Loren M Frank, Surya Ganguli, Adam Kepecs, Mark Alan Kramer, Christian Machens, Vanessa Tolosa
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain is a massively interconnected network of regions, each of which contains neural circuits that process information related to combinations of sensory, motor and internal variables.
Title
CoSMo - Summer School in Computational Sensory-Motor Neuroscience
Investigator
Paul R Schrater
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research.
Title
Dynamic network computations for foraging in an uncertain environment
Investigator
Dora Angelaki, Valentin Dragoi, Zachary Samuel Pitkow, Paul R Schrater
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain evolved complex recurrent networks to enable flexible behavior in a dynamic and uncertain world, but its computational strategies and underlying mechanisms remain poorly understood.
Title
Engineered viral tropism for cell-type specific manipulation of neuronal circuits
Investigator
Daniel Schmidt, Mark John Thomas
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): It is a longstanding goal in neuroscience to reveal how specific cell types contribute to different neural circuits that underlie cognition, behavior, and disease pathology.
Title
Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability
Investigator
Zhigang He
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The ability to examine the connectivity and functions of specific brain nuclei and specific neuron types is critical for understanding how the brain works at both microcircuit and mesoscale levels.
Title
Genetic tools and imaging technology for mapping cholinergic engrams of anxiety
Investigator
Lorna W Role
Institute
state university new york stony brook
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This application will develop new genetic tools and advance current procedures for precise and rapid mapping of behavior specific memory engrams.
Title
Interdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
Investigator
Satish S Nair
Institute
university of missouri-columbia
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states.
Title
Intrabody-dependent activation of cell-specific gene expression in CNS
Investigator
Seth Blackshaw
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The mammalian central nervous system (CNS) contains many hundreds of molecularly and functionally distinct cell types, which comprise the basic building blocks of neural circuitry.
Title
Lagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor Sequences
Investigator
Ryan Prescott Adams, Sandeep R Datta, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Behaviors are sequences of actions that are executed in the proper order and correct setting to achieve a goal.
Title
LIPS: A novel technology for spatial and temporal control of protein synthesis in dendritic spines
Investigator
Wenbiao Gan, Samie R Jaffrey
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The proteins in synapses are the fundamental regulators of synaptic plasticity, which ultimately controls the neural circuits that underlie behavior.
Title
MULTISCALE ANALYSIS OF SENSORY-MOTOR CORTICAL GATING IN BEHAVING MICE
Investigator
Dieter Jaeger, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): To address the core question underlying the Obama Brain Initiative to better understand the function of complex brain circuits, we propose a multi-scale recording and data analysis project to study the dynamical interactions between sensory cortex, motor cor
Title
Multiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and Function
Investigator
R Todd Constable, Michael C. Crair
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The purpose of this RFA is to promote the integration of experimental, analytic and theoretical capabilities for the examination of neural circuits and systems.
Title
Network basis of action selection
Investigator
Anatol Kreitzer, Takaki Komiyama, Byungkook Lim
Institute
j. david gladstone institutes
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The anatomical substrates and cellular mechanisms underlying reward-dependent learning have been studied for decades, but the specific circuit and network interactions between the cortex, striatum, and midbrain that mediate action selection have not been sys
Title
Neural ensembles underlying natural tracking behavior
Investigator
Ila R. Fiete, Alexander C Huk, Nicholas J Priebe
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The system that controls smooth pursuit eye movements is one of the most accessible, promising systems for understanding how neural circuits transform sensory inputs into actions.
Title
Novel tools for cell-specific imaging of functional connectivity and circuit operations
Investigator
Ehud Isacoff
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Fundamental to understanding brain function is the ability to relate the spatio-temporal firing patterns of specific neurons to their functional connectivity and determine the strength and experience-dependent regulation of those connections.
Title
Sparse, Strong and Large Area Targeting of Genetically Encoded Indicators
Investigator
Srdjan D Antic, Thomas Knopfel
Institute
university of connecticut sch of med/dnt
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Electrical (voltage) signal is the primary substrate of information processing in the brain. Detecting and recording voltage changes from neurons in living animals remains the ultimate goal of experimental neuroscience to the present day.