Abstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g.,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
1 mm resolution single-photon spectral imaging of the brain
Investigator
Ling-Jian Meng, Scott Dean Metzler
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
Title
A Dry Electrode for Universal Accessibility to EEG
Investigator
Walid Soussou
Institute
quasar, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Electroencephalography (EEG) measures the brain’s local field potential from the surface of the scalp. This method is useful for studying cognitive processes, neurological states, and medical conditions.
Title
A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy
Investigator
David A Boas, Xiaojun Cheng
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring
Title
Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology
Investigator
Fuyixue Wang
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Functional MRI (fMRI) is today the predominant tool for noninvasive imaging of brain function, which has revolutionized our understanding of the human brain.
Title
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease
Investigator
Dennis Alan Turner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
DBS therapy for Parkinson Disease [PD], the primary, FDA-approved surgical approach, has proven efficacious in clinical trials.
Title
An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates
Investigator
Karl A. Deisseroth, Eyal J Seidemann
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT Perceptually guided behavior involves a complex and dynamic interplay between external inputs and internal states that are related, for example, to alertness, motivation, expectations and attention.
Title
Analysis of modulation of the metabotropic glutamate receptor type 5 in a novel heritable model of drug abuse vulnerability
Investigator
Loren D Peeters
Institute
east tennessee state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Schizophrenia is a debilitating mental illness affecting an estimated 1% of the global population.
Title
Beyond dopamine: dual neuromodulator regulation of motor variability and learning
Investigator
Drew Clinton Schreiner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Learning and performing complex skills such as speech or music requires precise control of motor variability. While elevated motor variability can spur the learning of new behaviors, excessive variability can impair performance of learned skills.
Title
Biophysical Mechanisms of Cortical MicroStimulation
Investigator
Sydney S Cash, Mark Thomas Harnett
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Direct local electrical stimulation (DLES) is an increasingly important therapeutic tool for treating brain disorders such as Parkinson’s, epilepsy, and OCD.
Title
Boss: A cloud-based data archive for electron microscopy and x-ray microtomography
Investigator
Brock A. Wester
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT The generation of scientifically rich, high resolution neuroimaging volumes continues to increase in extent and rate due to the advancement of new Electron Microscopy (EM) and X-ray Microtomography (XRM) imaging sys- tems and data processing methodologies.
Title
Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex
Investigator
Deepa L Ramamurthy
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.
Title
Center for Advanced Muscle BioElectronics (CAMBER)
Investigator
Muhannad Bakir, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.
Title
Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke
Investigator
Jasmine Jamilah Cash
Institute
medical university of south carolina
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.
Title
Circuit mechanisms of arbitration between distinct reinforcement learning systems
Investigator
Margaret Louise Demaegd
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?
Title
Circuit-specific, chemogenetic neuromodulation in nonhuman primates.
Investigator
Serge E Przedborski, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.
Title
Cognitive and Neural Strategies for Latent Feature Inference
Investigator
Tahra Eissa
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.
Title
Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits
Investigator
Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher
Institute
blackrock microsystems
Fiscal Year
Funding Opportunities Number
Project Number
The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.
Title
Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits
Investigator
Christopher Versteeg
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?
Title
Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes
Investigator
Kip A Ludwig
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Despite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.
Title
Development of a combined Gamma/Positron system for molecular imaging of the human brain at sub-500 micron spatial resolution
Investigator
Shiva Abbaszadeh, Lars R Furenlid, Michael A King
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY We are proposing a new approach to a hybrid imaging modality that has been called “b+g” or “pamma-positron” Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two differ