PROJECT SUMMARY
Living organisms interact with complex environments that are inherently multisensory. Within these
environments, the brain must integrate information from multiple sensory modalities, including the auditory and
olfactory systems, for perception and behavior.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNeural mechanisms of multisensory auditory-olfactory integration in the auditory cortex
Investigator
Nathan Vogler
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural Mechanisms of Transcranial Current Stimulation
Investigator
Bart Krekelberg, Pierre- Olivier Polack
Institute
rutgers the state univ of nj newark
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Transcranial current stimulation (TCS) creates small electrical fields in the brain through electrodes placed on
the scalp.
TitleNeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform
Investigator
Qianqian Fang
Institute
northeastern university
Fiscal Year
Funding Opportunities Number
Project Number
Traditional file-based neuroimaging data management and integration strategies have shown
increasing limitations in accommodating the meteoric growth in both the scale and complexity of today’s
neuroimaging data.
TitleNIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species
Investigator
Oscar Esteban, Michael Peter Milham, Russell A Poldrack, Ariel Shalom Rokem, Theodore Satterthwaite
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Despite the rapid advances in the neuroimaging research workflow over the last decade, the enormous
variability between and within data types and specimens impedes integrated analyses.
TitleOpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function
Investigator
Christof Koch, Jerome Anthony-Jean Lecoq
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Over the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and
optical-physiology: together they form the Allen Brain Observatory.
TitleQuantitative Diffuse Correlation Spectroscopy for Assessing Human Brain Function
Investigator
Ulas Sunar
Institute
wright state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Acute brain injuries can lead to secondary brain damage that worsens the outcome. Reduced cerebral blood
flow can induce ischemia, while excess blood flow can cause hemorrhage.
TitleRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning
Investigator
Peter V. Kochunov, Paul M Thompson
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-
related patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing
Neuroimaging Genetics through Meta-Analysis (ENIGMA).
TitleResolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods
Investigator
Genevieve Lauren Stein-O'brien
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
High-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently
underway.
TitleRobotically-actuated, low-noise, concurrent TMS-EEG-fMRI system
Investigator
Chunlei Liu, Michael Lustig, Angel V Peterchev
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The ability to noninvasively modulate and image the brain with spatial and temporal precision is highly desirable
for understanding brain circuits in health and disease.
TitleScalable tools for consistent identification of neuronal cell types in mouse and human
Investigator
Staci A Sorensen, Uygar Sumbul
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by
developing machine learning algorithms and cloud-based software for the integration of multiple modality
characterizations large and growing datasets of cortical neurons in mou
TitleSecondary analysis of functional MRI and resting state connectivity in white matter
Investigator
John C Gore, Bennett A. Landman
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Abstract / Summary
This proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI
studies in order to quantify the functional characteristics of white matter (WM) and their changes during
normal aging and in the progression to Alzheimer’s Disease (AD).
TitleSensory motor transformations in human cortex
Investigator
Richard A Andersen
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: The long-term objective of this application is to understand cortical processing of sensory to
motor transformations within the human cerebral cortex. A vast number of computations must be
performed to achieve sensory-guided motor control.
TitleSex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
Investigator
Brandy A. Briones
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits.
TitleStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
Investigator
Daniel Lu
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Respiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure
is the leading cause of death in patients with SCI.
TitleStructure and function of spontaneous network activity during circuit formation
Investigator
Arnaldo Carreira-Rosario
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations
during this time can cause lifelong circuit and behavioral changes.
TitleSWITCH trial: Early feasibility study of Stentrode BCI for augmentative communication
Investigator
Nicholas Lachlan Opie, Thomas J Oxley, David Francis Putrino, Douglas J Weber
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary
Multiple early feasibility trials in humans have demonstrated that implantable Brain-Computer Interfaces (BCIs) can enable
people with severe paralysis to use neural signals to control remote and digital communication technologies, including
messaging and email.
TitleThalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome
Investigator
Martha J Morrell
Institute
neuropace, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive
dysfunction and very frequent generalized onset seizures (GOS) often leading to injury.
TitleThe representation and modulation of sensory information in the learning and memory center of the Drosophila brain
Investigator
Andrew M Davidson
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses the combined physiology of many cells to transform incoming sensory signals into internal
representations.
TitleThe role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior
Investigator
Sarah D Ackerman
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Significance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.
plasticity) to produce stereotyped behavior.
TitleThin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy
Investigator
Shadi Dayeh
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The goal of this project is to significantly advance the field of acute and semichronic epilepsy monitoring
using novel, high-resolution electrocorticography (ECoG) record/stimulate grids (4096/256 channels,
respectively) and stereoelectroencephalography (sEEG) depth electrodes (120/8 micr