PROJECT SUMMARY
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-
thalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely
human behavior is not clear, due to a lack of empirical data.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCortical-Basal Ganglia Speech Networks
Investigator
Robert Mark Richardson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
TitleCoupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis
Investigator
Daniel Maxim Iascone
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Circadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in
mammals [1-3].
TitleCritical Technology Development for 16 Tesla Head-only MRI Superconducting Persistent Magnets: V2
Investigator
Minfeng Xu
Institute
general electric global research ctr
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Advanced brain research demands ultra-high field MRI systems. The 11.7 T Neurospin CEA MRI magnet
pushed the use of superconducting NbTi materials to the limit by using superfluid helium to cool.
TitleCross-frequency coupling: its role in brain function and dysfunction
Investigator
Andrei V Medvedev
Institute
georgetown university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the
brain network dynamics across time and space from human electrophysiological recordings.
TitleData Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience
Investigator
Chun Chieh Fan, Wesley Kurt Thompson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Population neuroscience requires investigation of brain-behavioral relationships within epidemiological
samples studied in longitudinal designs, including a large number of assessment modalities and with subjects
enrolled at many data collection sites to achieve a large sample and br
TitleDataJoint Pipelines for Neurophysiology
Investigator
Dimitri Yatsenko
Institute
vathes inc.
Fiscal Year
Funding Opportunities Number
Project Number
The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data.
TitleDecision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.
TitleDefining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
TitleDevelopment of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
TitleDevelopmental cell census of human and non-human primate brain
Investigator
Nenad Sestan
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The human brain is a highly complex biological tissue organized into hundreds of regions composed of a myriad
of cell types with distinct molecular, morphological, and physiological properties.
TitleDissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
TitleDopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.
TitleDynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study
Investigator
Marsa Taheri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Astrocytes comprise up to half of mammalian brain cells.
TitleElucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology
Investigator
Takashi Daniel Yoshida Kozai
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an
increasingly prevalent clinical therapy.
TitleEthics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
TitleGenetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
TitleGenetic mechanisms specifying astrocyte functional diversity and their role in sleep
Investigator
Margaret Ho
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Astrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our
understanding of their identities and functions is far less comprehensive than for neurons.
TitleGraspy: A python package for rigorous statistical analysis of populations of attributed connectomes
Investigator
Carey Priebe, Joshua T Vogelstein
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Overview: We will extend and develop implementations of foundational methods for analyzing populations of
attributed connectomes.
TitleHighly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations
Investigator
Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national
Working Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and
generate evidence-based consensus recommendations for the ethical conduct
TitleHormonal regulation of value-based decision-making
Investigator
Carla Golden
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Individuals decide between alternatives based on their perceived value of the reward associated with each
option.