Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG
system that can operate without external shielding that will lead to Advances in Human Neuroscience and
transformative advances in our understanding of the Human Brain ‘in Action and in Context’,
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs
Investigator
Jose Luis Contreras-Vidal, Svenja Knappe
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
TitleA TOF, DOI, MRI compatible PET detector to support sub-millimeter neuroPET imaging
Investigator
Sergei Dolinsky, Robert S Miyaoka
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The overall goal of this research is to develop next generation positron emission tomography (PET) detector
technology to support non-invasive, quantitative brain imaging at spatial and temporal resolutions currently not
achievable with human neuro-PET systems.
TitleAssessing the Effects of Deep Brain Stimulation on Agency
Investigator
Adina L Roskies
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Recent advances in neurotechnologies have provided us with the ability to modulate brain function by
direct and indirect interventions.
TitleAuditory brain-computer interface for communication
Investigator
Daniel James Thengone
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamental end-goal of brain-computer interfaces (BCI) is to enable communication in individuals
with severe motor paralysis. BCIs decode the neural signals and accomplish the intended goal via an effector,
such as a computer cursor or a robotic limb.
TitleBreaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and Neuroenergetics
Investigator
Wei Chen, Xiao-Hong Zhu
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how neural circuits operate and interconnect at mesoscopic (sub-millimeter) scale, and how
neuroenergetic metabolism and neurotransmitters support brain function at resting and working state is
essential to brain research and BRAIN Initiative. Magnetic
TitleC-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparative
Investigator
Richard Cameron Craddock, Michael Peter Milham
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording,
and macroscale neuroimaging techniques in human and non-human animal models in order to develop a
multilevel understanding of human brain function.
TitleCausal mapping of emotion networks with concurrent electrical stimulation and fMRI
Investigator
Ralph Adolphs, Matthew A. Howard, Russell A Poldrack
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Understanding human brain function requires knowledge of its connectivity: how one structure
causally influences other components of the network.
TitleCausally linking dendritic Ca2+ dynamics to CA1 circuit function and spatial learning using novel tools to precisely manipulate an endogenous Ca2+ buffering process
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
In dendrites, Ca2+ is critical in determining how neurons respond to incoming excitation.
TitleCollaborative Standards for Brain Microscopy
Investigator
Carol Marie Hamilton
Institute
research triangle institute
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Fast microscopy techniques, coupled with recent advances in tissue clearing, are now able to efficiently
produce cellular-resolution images of intact brain samples.
TitleCombined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Investigator
Darin D Dougherty, Alik S Widge
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
This project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD
is a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms
after being treated with medication or talk therapy.
TitleConnectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Investigator
Peter J. Basser, Susie Yi Huang, Bruce R Rosen, Lawrence L Wald, Thomas Witzel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
We present Connectome 2.0, the next-generation human MRI scanner for imaging structural anatomy and
connectivity spanning the microscopic, mesoscopic and macroscopic scales.
TitleContext-dependent processing in sensorimotor cortex
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even
for seemingly simple tasks, a variety of sensory inputs are integrated to create a motor plan to complete a task.
Take the example of picking up a glass.
TitleCranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials
Investigator
Austin Robert Duke
Institute
nexeon medsystems puerto rico operating company, inc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The goal of this U44 proposal is to develop and test CranialProgrammer, an image-guided programming tool
for 2D/3D mapping of disease-related neural signals over patient and device data for more efficient and
effective programming of directional deep brain stimulation (DBS) systems.
TitleData interface and apps for systems neurophysiology and imaging
Investigator
Stephen D Van Hooser
Institute
brandeis university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Technology for recording from the brain is developing at a breakneck pace.
TitleDevelopment and Translation of an Intracranial Auditory Nerve Implant
Investigator
Robert Kyle Franklin, Thomas Lenarz, Hubert Hyungil Lim, Andrew J. Oxenham, Loren Rieth, Florian Solzbacher
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The proposed project will build and evaluate the safety and design needs of a new type of intracranial auditory
prosthesis that targets the auditory nerve between the cochlea and the brainstem (auditory nerve implant, ANI)
in order to substantially improve hearing performance over the curre
TitleDevelopment of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the positron emission tomography (PET) detector module for the next
generation 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved
spatio-temporal resolution.
TitleDissecting corticostriatal circuitry underlying chronic binge eating
Investigator
Britny Hildebrandt
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Eating disorders are severe psychiatric conditions with a significant worldwide cost and disability burden. Binge
eating (BE) is a behavior that cuts across nearly all eating disorder diagnoses.
TitleDynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks
Investigator
Gerwin Schalk
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Improved understanding of the brain processes underlying normal and abnormal function is necessary for
devising better ways to diagnose, alleviate, or cure neurological or psychiatric disorders.
TitleEarly Feasibility Clinical Trial of a Visual Cortical Prosthesis
Investigator
Jessy D Dorn, Robert Jay Greenberg, Nader Pouratian
Institute
second sight medical products, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Blindness in the United States is a large and increasing problem. Any significant vision loss is
debilitating, but profound blindness is devastating to an individual’s ability to be independent
and to perform everyday tasks and activities.
TitleEnabling Multi-Tracer SPECT Studies of the Human Brain
Investigator
Todd E Peterson
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Molecular imaging provides the means to quantitatively study many types of processes in the human brain in a
minimally invasive manner.