Project Summary The primary goal of this application is to elucidate the neural basis of resting-state
functional magnetic resonance imaging (rsfMRI) signal using multi-modal approaches including multi-echo (ME)-
rsfMRI, MR-compatible calcium signal recording, optogenetics and multi-laminar electrop
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleMechanistic dissection of the neural basis of the resting-state fMRI signal using multi-modal approaches
Investigator
Patrick James Drew, Nanyin Zhang
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
TitleMRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER
Investigator
David Alan Feinberg, Chunlei Liu, Pratik Mukherjee, Kawin Setsompop, Lawrence L Wald
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The overarching objective of our proposal is to bring noninvasive human brain imaging into the microscale
(50-500 micron isotropic) resolution in order to create a tool for studies of neuronal circuitry and network
organization in the human brain.
TitleMulti-context software for robust and reproducible neuroscience image analysis
Investigator
Xenophon Papademetris, Dustin Scheinost
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Abstract)
The goal of this application is to develop, test, and disseminate multi-context (command line, desktop, server,
and web applications) software for robust and reproducible neuroscience image analysis from data across mul-
tiple scales (two photon microscopy, mesoscale Ca2+
TitleNeuroethics of aDBS Systems Targeting Neuropsychiatric and Movement Disorders
Investigator
Wayne K Goodman, Gabriel Lazaro-Munoz, Amy L Mcguire
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Adaptive deep brain stimulation (aDBS) systems can record neural activity and adjust stimulation in real
time.
TitleNeuronal mechanisms of human episodic memory
Investigator
Adam Nathaniel Mamelak, Ueli Rutishauser
Institute
cedars-sinai medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The rapid formation of new memories and the recall of old memories to inform decisions is essential for human
cognition, but the underlying neural mechanisms remain poorly understood.
TitleNeurostimulation and Recording of Real World Spatial Navigation in Humans
Investigator
Nanthia A Suthana
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Decades of research and clinical observations have established that episodic memory, the ability to remember
recently experienced events, depends on the hippocampus and associated structures in the medial temporal
lobe (MTL), including entorhinal, perirhinal and parahippocam
TitleNoninvasive neuromodulation via focused ultrasonic drug uncaging
Investigator
Raag D Airan
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY .
In psychiatry, we are limited by the mismatch between the diverse heterogeneity of the brain and the tools we
have to treat it.
TitleNovel Neuromodulation by Transcranial Infrared Brain Stimulation with Imaging
Investigator
Francisco Gonzalez-Lima, Hanli Liu
Institute
university of texas arlington
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This project will develop a novel infrared-based neuro-stimulation tool for specifically modulating neural
circuitry. Transcranial infrared brain stimulation (TIBS) at 1064 nm will be developed as a new tool for non-
invasive neuromodulation of the human brain.
TitleResolving Fine Architectures of Human Gray Matter with Ultra-High-Resolution Diffusion MRI
Investigator
Yulin Ge, Jiangyang Zhang
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our brain is a complex network with multiple levels of organization in white matter (WM) and gray
matter (GM). The axonal and dendritic organizations of local GM tissue form one of the structural bases of
normal brain functions.
TitleReversing Synchronized Brain Circuits with Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts
Investigator
Susan E Shore
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The dorsal cochlear nucleus (DCN) integrates auditory and somatosensory information through circuitry that
modulates activity of the principal output neurons of the circuit, the fusiform cells.
TitleSABER: Scalable Analytics for Brain Exploration Research using X-Ray Microtomography and Electron Microscopy
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Advances in imaging have had a profound effect on our ability to generate high-resolution measurements of
the brain’s structure.
TitleScalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials
Investigator
Dennis Alan Turner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
DBS therapy for Parkinson's disease is now the primary surgical approach for Parkinson's disease, recently
FDA approved at 4 years after onset of disease.
TitleSpinal root stimulation for restoration of function in lower-limb amputees
Investigator
Lee E Fisher, Douglas J Weber
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Recent advances in design and actuation have led to important improvements in prosthetic limbs. However, these devices
lack a means for providing direct sensory feedback, requiring users to infer information about limb state from pressure on
the residual limb.
TitleTechnologies to drastically boost photon sensitivity for brain-dedicated PET
Investigator
Craig S Levin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
According to the BRAIN 2025 working group report, there is a need to drastically improve the spatiotemporal
resolution of positron emission tomography (PET), in order to facilitate the translation of new tracers that target
neuroreceptor function and dynamic PET imaging on t
TitleThe Application of Generalized Linear Models to Calcium Imaging Data for Optimal High-Dimensional Receptive Field Estimation and Identification of Latent Network Dynamics
Investigator
Stephen L Keeley
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
As new recording methods emerge in neuroscience, new statistical techniques are needed to properly relate
neural activity to behavior, a given stimulus, or an internal process.
TitleThe impact of cerebellar tDCS in local and downstream brain circuits: how much is neuralactivity modulated in the resting state and during sensorimotor processing?
Investigator
Javier F Medina
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Non-invasive stimulation of the cerebellum holds great promise for investigating brain function, and for
diagnosing and treating a variety of brain disorders.
TitleTranscranial magnetic stimulation with enhanced focality and depth (fdTMS)
Investigator
Angel V Peterchev
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
This project will develop transcranial magnetic stimulation coils with improved focality and depth (fdTMS).
TMS is a technique for noninvasive brain stimulation using strong, brief magnetic pulses. TMS is widely used in
the neurosciences as a tool for probing brain function and connectivity.
TitleUnderstanding the synaptic, cellular and circuit events of MEG & EEG using a vertically translational cross-species approach
Investigator
Chengcheng Huang, Dean F Salisbury, Tobias Teichert
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
7. PROJECT SUMMARY
Background. Electro- and magneto-encephalographic (EEG/MEG) responses to a stimulus are systematically
attenuated– by up to 80%– if the same stimulus was presented less than 8-12 seconds ago.
TitleUsing fMRI to Measure the Neural-level Signals Underlying Population-level Responses
Investigator
Rosemary Alice Cowell, David Ernest Huber
Institute
university of massachusetts amherst
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The goal of this proposal is to advance our ability to accurately infer the properties of neu-
ral-level responses from the more coarse-grained information obtained with non-invasive imaging in humans.
To achieve this goal, the project will capitalize on feature-selective cortical r
TitleA tool-box to control and enhance tDCS spatial precision
Investigator
Marom Bikson
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
Aimed at revolutionizing our understanding of the brain, the BRAIN initiative calls for “improvement of existing non-invasive neuromodulation” techniques.