Project Description
Functional MRI (fMRI) based on the blood oxygenation level dependent (BOLD) contrast has become a
powerful neuroimaging modality and has gained a prominent position in neuroscience for imaging brain
activation at working state and functional connectivity at rest.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleIntegrated fMRI Methods to Study Neurophysiology and Circuit Dynamics at Laminar and Columnar Level
Investigator
Wei Chen
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
TitleIntegrated multichannel system for transcranial magnetic stimulation and parallel magnetic resonance imaging
Investigator
Aapo Nummenmaa
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract:
During the past two decades, functional Magnetic Resonance Imaging (fMRI) has become ubiquitous in
studies of the human brain function. Similarly, Transcranial Magnetic Stimulation (TMS) has established its role
as one of the most widely used neuromodulation techniques.
TitleInvasive Approach to Model Human Cortex-Basal Ganglia Action-Regulating Networks
Investigator
Nader Pouratian
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Action initiation and withholding are key parts of everyday behavior, and underlying these is action
suppression.
TitleMicro-TMS Technology for Ultra-Focal Brain Stimulation
Investigator
Giorgio Bonmassar
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Micro-magnetic stimulation (μMS) is an emerging technology with a great promise to revolutionize therapeutic
stimulation of human nervous system.
TitleMicroscopic foundation of multimodal human imaging
Investigator
Anders M Dale, Anna Devor
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
The computational properties of the human brain arise from an intricate interplay between billions of neurons
connected in complex networks. However, our ability to study these networks in healthy human brain is limited
by the necessity to use noninvasive technologies.
TitleMR-guided Focused Ultrasound Neuromodulation of Deep Brain Structures
Investigator
Kim Butts-Pauly
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Completely noninvasive neuromodulation using focused ultrasound (FUS) offers the promise of precisely
stimulating specific targets deep in the brain. FUS is already used to deliver precise ablations deep in the
brain.
TitleMulti-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain Structures
Investigator
Polina O Anikeeva, Arnd Pralle
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This project seeks to develop a wireless, minimally invasive bi-directional deep brain stimulation technology
based on remote heating of magnetic nanoparticles.
TitleNeuromodulation by Transcranial Current Stimulation
Investigator
Bart Krekelberg
Institute
rutgers the state univ of nj newark
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A novel technique called transcranial current stimulation (TCS) creates small
electrical fields in the brain through electrodes placed on the scalp.
TitleNeuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
Investigator
Matthew A. Howard, John P O'doherty, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Neuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
PIs: Dr. John P. O'Doherty and Dr.
TitleNeurons, Vessels and Voxels: Multi-modal Imaging of Layer Specific Signals
Investigator
Prakash Kara, Thomas P Naselaris, Cheryl A. Olman, Kamil Ugurbil
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Our knowledge of signal processing in various parts of the human brain has been heavily influenced by non-
invasive functional magnetic resonance imaging (fMRI) experiments. FMRI infers the location and selectivity of
neural activity from vascular signals.
TitleNon-invasive neuromodulation mechanisms and dose/response metrics
Investigator
Desmond Oathes
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
In an exciting era of growth in the use of non-invasive brain stimulation, new methods and applications are
being disseminated widely with an increasing number of FDA approvals and equipment designed to probe or
modulate the brain in fascinating new ways.
TitleNoninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's Disease
Investigator
Harrison Carroll Walker
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
It is easy to underestimate the importance of normal movement in daily life, until that ability is altered or taken
away by disease.
TitleOptimized dosing of repetitive transcranial magnetic stimulation for enhancement of hippocampal-cortical networks
Investigator
Joel L Voss
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Memory impairment occurs in a variety of neuropsychiatric conditions (e.g., depression and schizophrenia) and
in many neurologic disorders (e.g., neurodegenerative disease and brain injury), often with devastating
consequences for life quality.
TitleOptimizing peripheral stimulation parameters to modulate the sensorimotor cortex for post-stroke motor recovery
Investigator
Karunesh Ganguly
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Stroke is the leading cause of disability in the United States, with approximately 700,000 new cases per
year. Disability from upper limb impairment depends primarily on loss of hand function and finger
dexterity.
TitleQuiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System
Investigator
Angel V Peterchev
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
This project will develop a low-noise transcranial magnetic stimulation (TMS) system. TMS is a technique
for non-invasive brain stimulation using strong, brief magnetic pulses. TMS is widely used as a tool for probing
brain function and is an FDA approved treatment for depression.
TitleRational Optimization of tACS for Targeting Thalamo-Cortical Oscillations
Investigator
Flavio Frohlich
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH
The alpha oscillation is a thalamo-cortical rhythm (8-12 Hz) that serves important functional roles in
cognition and behavior.
TitleResting state connectivity: Biophysical basis for and improved fMRI measurements
Investigator
David Kleinfeld, Bruce R Rosen
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Principal Investigators(Last, first, middle):KLEINFELD, DAVID and ROSEN, BRUCE R.
Functional magnetic resonant imaging (fMRI) is the only means to infer neuronal activity within the
entire volume of the human brain.
TitleShort Course in Adaptive Neurotechnologies
Investigator
Gerwin Schalk, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurological disorders affect many millions of people in the United States and throughout the world.
TitleSpatiotemporal signatures of neural activity and neurophysiology in the BOLD signal
Investigator
Shella D Keilholz
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
The blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) fluctuations used to
map functional connectivity contain a wealth of information about neural activity and physiological processes
in the brain.
TitleSubthalamic and corticosubthalamic coding of speech production
Investigator
Robert Mark Richardson
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Speech production and control is disrupted in a number of neurological diseases that involve the basal ganglia.
Notably, hypophonia and hypokinetic dysarthria (characterized by decreased motor gain) are prevalent in
patients with Parkinson's disease (PD).