Project Summary
This RFA is aimed at bringing together interdisciplinary teams to focus on novel, transformative and integrative
efforts that will revolutionize our understanding of the biological and bioinformatics content of the data collected
from non-invasive human functional brain imaging techn
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleUnderstanding evoked and resting-state fMRI through multi scale imaging
Investigator
R Todd Constable, Michael C. Crair, Dewan Syed Fahmeed Hyder
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
TitleUnderstanding the Neural Basis of Volitional State through Continuous Recordings in Humans
Investigator
Sydney S Cash
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
In the course of a day we naturally make multiple shifts in our overall cognitive state and in our aims and
intents. We go from sleep to awake, from internal dialogue to external communication, from relative immobility
to planned complex movements.
TitleWearable Transcranial Focused Ultrasound System for Region-specific Functional Neuromodulation
Investigator
Seung-Schik Yoo
Institute
brigham and women's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The main objective of the proposed research is to develop a wearable transcranial focused ultrasound
(tFUS) environment that reversibly modulates (either elicits or suppresses) region-specific neural
activities of the brain.
TitleBerkeley Course on Mining and Modeling of Neuroscience Data
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled "Mining and Modeling of Neuroscience Data" which is held at UC Berkeley.
TitleCentral thalamic stimulation for traumatic brain injury
Investigator
Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments.
TitleCoSMo - Summer School in Computational Sensory-Motor Neuroscience
Investigator
Paul R Schrater
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research.
TitleHigh resolution electrical brain mapping by real-time and portable 4D Acoustoelectric Imaging
Investigator
Russell S Witte
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Our vision is to develop the first noninvasive, real-time and portable electrical brain mapping system based on disruptive acoustoelectric (AE) technology.
TitleHigh-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording
Investigator
Leigh R Hochberg, Arto Nurmikko
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurologic disorders including cervical spinal cord injury, brainstem stroke, and amyotrophic lateral sclerosis can lead to severe paralysis of all fou limbs.
TitleInterdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
Investigator
Satish S Nair
Institute
university of missouri-columbia
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states.
TitleNeuron selective modulation of brain circuitry in non-human primates
Investigator
Charles F Caskey, Li Min Chen, William A Grissom
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for brain circuit investigation.
TitleNeurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
Investigator
Gregory A Worrell
Institute
mayo clinic rochester
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Approximately 1/3 of people living with epilepsy (PWE) continue to have seizures despite anti-epileptic drugs (AEDs). Recent trials using therapeutic brain stimulation show reductions in seizures, but rarely provide seizure free outcomes.
TitleSonoelectric tomography (SET): High-resolution noninvasive neuronal current tomography
Investigator
Matti Hamalainen, Partha Pratim Mitra, Nathan J. Mcdannold, Yoshio Okada
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Presently there is no imaging technology capable of detecting neuronal activity in the entire human brain with millisecond and millimeter resolution.
TitleToward functional molecular neuroimaging using vasoactive probes in human subjects.
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The establishment of new and precise strategies for mapping brain activity in human subjects is one of the highest priorities of the BRAIN Initiative.
TitleVirtual Brain Electrode (VIBE) for Imaging Neuronal Activity
Investigator
Jeff W Bulte
Institute
hugo w. moser res inst kennedy krieger
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A technique will be developed to determine where in the brain the signal in an electroencephalogram (EEG) is originating from in order to generate a "voxel-specific EEG", much like the signal coming from an implanted electrode.
TitleAdvancing MRI & MRS Technologies for Studying Human Brain Function and Energetics
Investigator
Wei Chen, Qing X Yang
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Magnetic resonance (MR) imaging (MRI) and in vivo MR spectroscopy (MRS) techniques have become indispensable tools for imaging brain structure, function, connectivity, neurochemistry and neuroenergetics, and for investigating neurological disorders.
TitleDissecting human brain circuits in vivo using ultrasonic neuromodulation
Investigator
Mikhail Shapiro, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A dream of neuroscience is to be able to non-invasively modulate any given region of the human brain with high spatial resolution.
TitleImaging Brain Function in Real World Environments & Populations with Portable MRI
Investigator
Michael Garwood, John T Vaughan
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) continues to play a critical role in understanding the human brain.
TitleImaging in vivo neurotransmitter modulation of brain network activity in realtime
Investigator
Albert Gjedde, Arman Rahmim, Dean Foster Wong
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuronal depolarization and neurotransmitter release underlie some of the most fundamental components of normal physiology and the etiology of brain pathophysiology.
TitleImaging the Brain in Motion: The Ambulatory Micro-Dose, Wearable PET Brain Imager
Investigator
Julie Ann Brefczynski-Lewis
Institute
west virginia university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Our vision is to design the first truly mobile molecular brain imager that can be used on healthy subjects to study the functioning of the human brain during motion.
TitleMagnetic Particle Imaging (MPI) for Functional Brain Imaging in Humans
Investigator
Steven M Conolly, Mark Griswold, Lawrence L Wald
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): In this planning grant we propose several engineering developments to advance Magnetic Particle Imaging (MPI) to replace MRI as the next-generation functional brain imaging tool for human neuroscience.