Essential tremor (ET) is a common neurologic disorder affecting over 10 million people in the United States. Pathologic synchrony in the cerebello-thalamo-cortical (CTC) network has been considered to underlie the development of ET.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Thalamic Coordinated Reset Deep Brain Stimulation for Upper Extremity Essential Tremor: Proof of Principle Study
Investigator
Jerrold L Vitek, Jing Wang
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Title
The development of multimodal dynamics in a short-term memory system
Investigator
Gregory Patrick Davis
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.
Title
The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia
Investigator
David Narvaiz
Institute
baylor university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.
Title
The Neuroimaging Brain Chart Software Suite
Investigator
Christos Davatzikos, Yong Fan, Ilya M Nasrallah, Haochang Shou
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.
Title
Time-varying spatiotemporal causal interactions in the functional brain networks
Investigator
Nan Xu
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
This proposal describes a five-year career development program to prepare the candidate, Dr.
Title
Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform
Investigator
Patrick Goodwill
Institute
magnetic insight, inc.
Fiscal Year
Funding Opportunities Number
Project Number
In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen
Title
Understanding the Conceptual Priority Map Guiding Naturalistic Visual Attention for Autistic Individuals
Investigator
Amanda J Haskins
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).
Title
UNDERSTANDING THE CONSEQUENCES OF SLEEP LOSS IN AN AUTISM MOUSE MODEL
Investigator
Elizabeth Medina
Institute
washington state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.
Title
Wireless Implantable COrtical Neuroprosthetic System (W-ICONS)
Investigator
Francesco V Tenore
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to develop a Wireless, fully Implantable, bidirectional Cortical Neuroprosthetic System (W-ICONS) for restoring sensorimotor function through an interface with intact upper limb areas of primary motor and sensory cortex.
Title
A BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive
Investigator
Anup Mahurkar, Owen R White
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative
promotes the development and application of technologies to describe the temporal and spatial
dynamics of cell types and neural circuits in the brain.
Title
A Confocal Fluorescence Microscopy Brain Data Archive
Investigator
Marcel P Bruchez, Alexander J Ropelewski, Alan Michael Watson
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Brain image data collected by the neuroscience community will continue to grow
dramatically in the next 5-10 years as the push to image physically larger volumes, such as
whole brains from humans and other primates, becomes a focus.
Title
A Shared Neuroscience Platform for National Dissemination and Training in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies
Investigator
William T Newsome, Sergiu Pasca, Mehrdad Shamloo, Gordon X Wang
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out
functional and mechanistic studies accompanied by advanced imaging techniques.
Title
A staged, comprehensive investigation for developing insular deep brain stimulation to treat refractory chronic pain
Investigator
William Jeffrey Elias, Chang-Chia Liu
Institute
university of virginia
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Patients with refractory chronic pain typically do not respond to traditional analgesics or weak opioids
as these agents do not directly address the cause for their pain.
Title
Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments
Investigator
Kaysaw C Tuy
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Perturbations in redox signaling are associated with multiple neurological disorders, ranging from
neurodegenerative diseases to brain tumors.
Title
Advancing epilepsy diagnosis with flexible, high-resolution thin-film electrodes
Investigator
Robert Kyle Franklin, Daniel Friedman, Bijan Pesaran, Florian Solzbacher, Jonathan Viventi
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
To advance the development of next-generation personalized therapies for long-term seizure freedom, we
urgently need technologies that improve seizure diagnostics while reducing risks associated with invasive
neurosurgical procedures.
Title
An acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scanners
Investigator
Kawin Setsompop
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Functional MRI (fMRI) is the most widely-used tool to noninvasively measure brain function and has produced
much of our current knowledge about the functional organization of the human brain.
Title
Anatomical connectivity and activity in primary visual cortex of mouse
Investigator
Zachary Samuel Pitkow, Andreas Tolias
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Estimates of the total length of axonal "wiring" in the human brain are on the order of hundreds of thousands
of kilometers.
Title
Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion
Investigator
Alesa Hughson Netzley
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Traumatic brain injury (TBI) is a leading health concern for both children and adults worldwide.
Title
Basic neural processing mechanisms of live human face viewing
Investigator
Megan Kelley
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Significance. The human brain has a dedicated neural system for processing other humans. However relatively
little is known about the basic mechanisms of this processing.
Title
BCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework
Investigator
Karen G Hirsch, Holly K Tabor
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The objective of “Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-
DEF)” is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to
assess and analyze diverse, critical stakeholder perspective