Project Abstract
The first postnatal years are an exceptionally dynamic and critical period of structural and functional development
of the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development
during this stage.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleHarmonizing and Archiving of Large-scale Infant Neuroimaging Data
Investigator
Gang Li
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
TitleHemogenetic imaging technology for circuit-specific analysis of primate brain function
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Primate brains contain cortical areas that exhibit selective engagement in high-level sensory or behavioral
operations. The functional specialization of these regions is thought to be central to primate-specific cognitive
faculties and to associated disorders.
TitleHeritability and cognitive implications of structural-functional connectome coupling
Investigator
Amy Kuceyeski
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex
thought, emotion and behavior.
TitleImaging Dynamics in Anxiogenic Serotonin Circuitry
Investigator
Emily Clarissa Wright
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Serotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-
specific dynamics are little understood.
TitleInfluence of task complexity and sensory feedback on cortical control of grasp force
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,
and as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve
and maintain an appropriate grasp force.
TitleIntegrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources
Investigator
Mark Bender Gerstein, Avram J Holmes
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Constructing an integrated picture of human brain function requires understanding how the effects of molecular
and genetic factors propagate upwards, through many intervening layers of structure and interaction, to
influence behavioral, psychiatric and cognitive traits.
TitleIntegrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks
Investigator
Mikail Rubinov
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Brain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic—
e.g. genomic and transcriptomic—datasets.
TitleInterrogating the propagation of electrical stimulation across scales in vivo
Investigator
Daniel James Denman
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Intracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in
several animal model systems. However, little is actually known about the ensembles of neurons activated by
typical and clinical intracranial EBS protocols.
TitleInvestigating Functional Ependymal Cell Heterogeneity in the Ventricular System
Investigator
Stephanie Redmond
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract:
Glial cells collectively outnumber neurons in the vertebrate brain, but mechanistic understanding of their
molecular subtypes and functions is lacking.
TitleiSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains
Investigator
Hong Chen, Ilya E. Monosov
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Critical advances in the treatment of human brain disorders are hindered by our inability to specifically target
dysfunctional circuitry in a safe and noninvasive manner.
TitleLong-range neuronal projections: circuit blueprint or stochastic targeting? Rigorous classification of brain-wide axonal reconstructions
Investigator
Giorgio A Ascoli
Institute
george mason university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT (PROJECT SUMMARY)
The classification of neurons in the mammalian brain has long been a focus of intensive investigation in
neuroscience.
TitleMap Manager: Longitudinal image analysis with online editing and sharing.
Investigator
Robert Harry Cudmore
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
The increasing availability and ease of use of confocal, two-photon, and light-sheet microscopes coupled with
rapid developments in fluorescent protein reporters have made 3D and functional imaging and its analysis a
central component of modern Neuroscience research.
TitleMapping Algorithmic State Space in the Human Brain
Investigator
Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this
cognitive flexibility is our ability to respond correctly to novel contextual situations on the first attempt, without
prior rehearsal.
TitleMapping thalamo-striatal neuronal circuits underlying motivational drive
Investigator
Sofia Beas
Institute
national institute of mental health
Fiscal Year
Funding Opportunities Number
Project Number
Motivational drive is an adaptive process that helps individuals overcome obstacles to obtain essential needs and hence ensure survival. Motivation is composed of two major components.
TitleMechanisms of basal forebrain control over sensory processing
Investigator
Elizabeth Hanson Moss
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A key problem in neuroscience is understanding how internal and external information are integrated in the brain to produce
sensory experiences, cognition, and behavioral responses.
TitleMolecular identity, cellular physiology, and in vivo functions of nucleus accumbens astrocytes
Investigator
Kay Elizabeth Linker
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Astrocytes are pervasive throughout the CNS and are the most abundant non-neuronal cell type. They
are an essential component of neural circuits, and increasing evidence demonstrates they are specialized for
specific brain regions.
TitlemRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes
Investigator
Melissa Mckenzie Campbell
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Alternative splicing of pre-mRNAs is extensively employed by the nervous system to expand the transcriptomic
manifold.
TitleNABOR: A Sustainable, High-quality Neuroscience Antibody Open Resource
Investigator
Melina Fan
Institute
addgene, inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of this project is to build an open-access recombinant antibody/affinity reagent resource for the
neuroscience community called NABOR (Neuroscience AntiBody Open Resource).
TitleNational Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
Investigator
Mark H Ellisman
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
This project aims to disseminate validated technologies and resources of the National Center for Microscopy
and Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN
Initiative.
TitleNeural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networks
Investigator
Preeya Khanna
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years.