PROJECT SUMMARY
Corticospinal axonal projections are critical for mammalian motor control.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Brainstem circuits of corticospinal neurons
Investigator
Gordon M Shepherd
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Title
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitry
Investigator
Franck K Kalume, Ed Lein, Boaz Pirie Levi, Jonathan T Ting
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Many cell types together assemble the functional circuitry of the human brain. For over a century, neuroscientists
have categorized brain cell types by their features, including shape, position, physiology, molecules, and
function.
Title
Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature
Investigator
Lily Y Jan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic
feedback regulation based on monitoring the temperature of internal organs as well as the environment.
Homeostatic thermoregulation in response to changes of brain temp
Title
Characterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces
Investigator
Karen Elizabeth Schroeder
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in
neural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish
an independent nonhuman primate (NHP) laboratory with two primary aims.
Title
Circuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.
Investigator
Brandon J Mark
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise
control of large numbers of motor neurons.
Title
Circuit dynamics of sensorimotor integration and decision making in octopus
Investigator
Galit Pelled
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this proposal is to identify fundamental sensorimotor circuits associated with
goal-oriented gripping movement by using high-dimensional biological, analytical and robotics
technologies.
Title
Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI
Investigator
Jonathan D Cohen, Kenneth A Norman
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: (30 lines of text max)
We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback
experiments.
Title
Combined Topological and Machine Learning Tools for Neuroscience
Investigator
Michael Hawrylycz, Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Two major recent advances have raised the possibility of fundamental breakthroughs in both
basic and clinical neuroscience: the development of new tools to probe the nervous system with
single-cell resolution as well as brain-wide scope, and breakthroughs in machine learning
methods for handling com
Title
Connecting neural circuit architecture and experience-driven probabilistic computations
Investigator
Zachary Peter Kilpatrick
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Organisms' actions and decisions are guided by experience. Models of such behavior often
appeal to the formalism of probabilistic inference, in which expectations about the world build up sequentially
due to past observations.
Title
Context-dependent neural processing of leg proprioception in Drosophila
Investigator
Sweta Agrawal
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair
balance, motor coordination, and motor learning.
Title
Cortical circuitry supporting flexible audiovisual interactions and behaviors
Investigator
Andrea Rayne Hasenstaub
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Interactions between the auditory and visual systems are among the most well-established cases of
crossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining
processing confined to a single modality and we understand comparatively l
Title
Cortical-Basal Ganglia Speech Networks
Investigator
Robert Mark Richardson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-
thalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely
human behavior is not clear, due to a lack of empirical data.
Title
Corticostriatal contributions to motor exploration and reinforcement
Investigator
Timothy James Gardner, Carlos Lois, Richard D. Mooney, John Pearson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Complex motor sequences are fundamental to many highly skilled behaviors, ranging from athletics to musical
and vocal expression.
Title
Corticostriatal mechanisms of causal inference and temporal credit assignment.
Investigator
Hyojung Seo
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Learning desired actions from experience requires evaluating alternative actions by integrating the
consequences assigned to each action over time.
Title
Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis
Investigator
Daniel Maxim Iascone
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Circadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in
mammals [1-3].
Title
Cross-frequency coupling: its role in brain function and dysfunction
Investigator
Andrei V Medvedev
Institute
georgetown university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the
brain network dynamics across time and space from human electrophysiological recordings.
Title
Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activity
Investigator
Shella D Keilholz, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
The brain is a complex dynamical system, with a hierarchy of spatial and temporal scales ranging from microns
and milliseconds to centimeters and years. Activity at any given scale contributes to activity at the scales above
it and can influence activity at smaller scales.
Title
Data Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience
Investigator
Chun Chieh Fan, Wesley Kurt Thompson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Population neuroscience requires investigation of brain-behavioral relationships within epidemiological
samples studied in longitudinal designs, including a large number of assessment modalities and with subjects
enrolled at many data collection sites to achieve a large sample and br
Title
DataJoint Pipelines for Neurophysiology
Investigator
Dimitri Yatsenko
Institute
vathes inc.
Fiscal Year
Funding Opportunities Number
Project Number
The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data.
Title
Decision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.