ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Defining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Title
Determining computational principles governing neural circuits responsible for feedback and movement control of D. melanogaster flight
Investigator
Itai Cohen
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A principle aim of the NINDS is to determine how motor control is successfully implemented by
the nervous system. Locomotion and balance are complex motor functions that are largely
controlled by complex microcircuits that reside outside the brain.
Title
Developing A Mouse Chronic Pain Scale by 3D Imaging and Measurement of Mouse Spontaneous Behaviors
Investigator
Long Ding, Wenqin Luo, Hyun Soo Park
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Rodent models are highly valuable for elucidating the molecular and cellular mechanisms of chronic pain.
Because rodents cannot articulate their sensation, “pain-like” behaviors have been used as the proxy.
However, sensitivity and specificity of many existing methods for measuring r
Title
Development of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
Title
Dissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
Title
Distributional reinforcement learning in the brain.
Investigator
Jan Drugowitsch, Naoshige Uchida
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The field of artificial intelligence (AI) has recently made remarkable advances that resulted in new and
improved algorithms and network architectures that proved efficient empirically in silico.
Title
Dopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.
Title
Dynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study
Investigator
Marsa Taheri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Astrocytes comprise up to half of mammalian brain cells.
Title
Ethics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
Title
From ion channels to graph theory in sensorimotor learning
Investigator
Genevieve Konopka, Daniel Margoliash, Jason Neil Maclean, Todd F Roberts
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of
individuals is an overarching goal of neuroscience.
Title
Functional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning
Investigator
Shogo Ohmae
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum performs information processing for motor control and various cognitive functions in
cooperation with the cerebral neocortex.
Title
Genetic access and connectional assays of mouse inhibitory cortical cell types
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
Title
Genetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
Title
Genetic mechanisms specifying astrocyte functional diversity and their role in sleep
Investigator
Margaret Ho
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Astrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our
understanding of their identities and functions is far less comprehensive than for neurons.
Title
Graspy: A python package for rigorous statistical analysis of populations of attributed connectomes
Investigator
Carey Priebe, Joshua T Vogelstein
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Overview: We will extend and develop implementations of foundational methods for analyzing populations of
attributed connectomes.
Title
Highly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations
Investigator
Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national
Working Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and
generate evidence-based consensus recommendations for the ethical conduct
Title
Hormonal regulation of value-based decision-making
Investigator
Carla Golden
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Individuals decide between alternatives based on their perceived value of the reward associated with each
option.
Title
How do parvalbumin interneuron-generated gamma oscillations organize prefrontal networks to promote behavioral adaptation?
Investigator
Vikaas Singh Sohal
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Rhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many
cases these oscillations are synchronized across brain regions.
Title
Identifying mediators of sex hormone uptake and signaling
Investigator
Nicole Yishi Leung
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Sex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes
across our lifespan.
Title
Improving Brain Organoid Models by Mediating Metabolic Dysregulation
Investigator
Madeline Andrews
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is currently an unmet need for accurate model systems of the human brain to study its cellular and
molecular features.