Project Summary
Integration of sensory information with motor commands allows movement to be adaptable. For example,
many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement
trajectories based on interaction with objects (e.g.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleProprioceptive Coding of Jaw Movement during Orofacial Behavior
Investigator
William Paul Olson
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
TitleQuantifying causality for neuroscience
Investigator
Konrad P. Kording
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Causality is central to neuroscience. For example, we might ask about the causal effect of a neuron on another
neuron, or its influence on perception, action, or cognition. Moreover, any medical approaches aim at
producing a causal effect – effecting improvements for patients.
TitleRelating functional MRI to neuronal activity: accounting for effects of microarchitecture
Investigator
Anna I Blazejewska
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits.
TitleResponsive Neurostimulation for Loss of Control Eating
Investigator
Casey Harrison Halpern, James D Lock, Robert C Malenka, Tara L Skarpaas (Crowder)
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Background/Description.
TitleResponsive Neurostimulation for Post-Traumatic Stress Disorder
Investigator
Jean-Philippe Langevin
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Post-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its
biological substrate, amygdala reactivity to trauma reminders13,14.
TitleRevealing neural computations through combined optical and electrical recordings
Investigator
Gregory Darin Field, Alexander Sher
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A major limitation to understanding the brain is a shortage of technologies for tracking the
activity of large populations of individual neurons across multiple layers of synaptic processing.
Ideally, these measurements of population activity would be compatible with both optogenetic
TitleRevealing the transcriptional and developmental mechanisms of interneuron identity
Investigator
Megan Crow
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Cortical GABAergic interneurons are critical components of neural circuitry, and their dysfunction has been
linked to neurodevelopmental diseases.
TitleSensory recruitment by working memory: neuronal basis and neural circuitry
Investigator
Behrad Noudoost
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Working memory maintenance is fundamental for the orderly pursuit of goals in the
face of irrelevant, distracting stimuli.
TitleSingle Neuron Analyzer for Multi-modal, Cross-dataset (Epi)genomic Cell Type Datasets
Investigator
Eran A Mukamel
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Our project will create a computational resource, the Single Neuron Analyzer, to support the neuroscience
community’s efforts to build a reproducible, comprehensive, data-driven atlas of brain cell types.
TitleSpinal Circuits for the Control of Dextrous Movement
Investigator
Martyn D Goulding
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Overall
Local networks within the spinal cord represent an essential computational layer for the control of limb-driven
motor behaviors, integrating descending and sensory inputs to coordinate dexterous motor output.
TitleStructural and functional connectivity of the social decision-making network
Investigator
Adam Steven Smith
Institute
university of kansas lawrence
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Humans and numerous other species live in complex social environments, requiring many of our most important
decisions to be made in the context of social interactions.
TitleStructural, single-cell transcriptomic, and functional 3-photon mapping of spinal pain circuits
Investigator
Prakash Kara, Suhasa B Kodandaramaiah, Lyudmila H Vulchanova
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Spinal dorsal horn interneurons (IN) integrate somatosensory inputs and control their access to spinal
projection neurons (PrN) that transmit nociceptive information to supraspinal components of pain pathways.
The heterogeneity of dorsal horn neurons, limited knowledge on their conne
TitleSubcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During Behavior
Investigator
Mai-Anh Vu
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The basal ganglia are a group of deep brain nuclei that play a central role in motivating, selecting, and learning
actions.
TitleTechnology development for closed-loop deep brain stimulation to treat refractory neuropathic pain
Investigator
Edward Chang, Philip Andrew Starr
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Many pain syndromes are notoriously refractory to almost all treatment and pose significant costs to patients
and society. Deep brain stimulation (DBS) for refractory pain disorders showed early promise but
demonstration of long-term efficacy is lacking.
TitleThe cerebro-cerebellar-basal-gangliar network for visuomotor learning
Investigator
Stefano Fusi, Michael E. Goldberg, Peter Strick
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Visual learning is critical to the lives of human and non-human primates. Visuomotor association, the
assignment of an arbitrary symbol to a particular movement (like a red light to a braking movement), is a well-
studied form of visual learning.
TitleThe Neural Mechanism of Interval Timing in Drosophila
Investigator
Ashley Danielle Smart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is no dedicated sensory organ for time, and yet our brains are able to use time to anticipate the
environment and adapt.
TitleThe Neuroimaging Data Model: FAIR descriptors of Brain Initiative Imaging Experiments
Investigator
David Bryant Keator
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Reuse of existing neuroscience data relies, in part, on our ability to understand the experimental design and
study data.
TitleTime-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain
Investigator
Maria Angela Franceschini
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Functional near-infrared spectroscopy (fNIRS) is a well-established neuroimaging method which enables
neuroscientists to study brain activity by non-invasively monitoring hemodynamic changes in the cerebral cortex.
In the last decade, the use of fNIRS has increased significa
TitleTools for modeling state-dependent sensory encoding by neural populations across spatial and temporal scales
Investigator
Stephen V David, Nima Mesgarani
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Throughout life, humans and other animals learn statistical regularities in the natural acoustic environment.
They adapt their hearing to emphasize the features of sound that are important for making behavioral
decisions.
TitleTowards a unified framework for dopamine signaling in the striatum
Investigator
John Assad, Sandeep R Datta, Samuel J Gershman, Scott Warren Linderman, Bernardo L Sabatini, Naoshige Uchida, Linda E Wilbrecht
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project abstract
Animals, including humans, interact with their environment via self-generated and continuous actions that
enable them to explore and subsequently experience the positive and negative consequences of their actions.
As a result of their interactions with the environment, animals alter