Project Summary/Abstract
Brain function is produced by the coordinated activity of multiple neuronal types that are widely distributed
across many brain regions.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNWB:N: A Data Standard and Software Ecosystem for Neurophysiology
Investigator
Lydia Lup-Ming Ng, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
TitleOptical measurement of causal functional connectivity in posterior parietal cortex
Investigator
Daniel E Wilson
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The mouse posterior parietal cortex (PPC) has emerged as an essential region for decision-making during
memory-guided decision-making tasks.
TitleOptimizing noninvasive modulation of prediction and episodic memory networks via cerebellar stimulation
Investigator
Shruti Dave
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY ABSTRACT
The lateral cerebellum (Crus I/II) interacts with two dissociable large-scale brain networks — the executive
control (ECN) and default mode networks (DMN), which support distinct cognitive functions (e.g., prediction
versus episodic memory, respectively).
TitleOxytocin Modulation of Neural Circuit Function and Behavior
Investigator
Richard W Tsien
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction and maternal
behavior. Recent studies have tagged oxytocin as a “trust” hormone, promising to improve social deficits in
various mental disorders, such as autism.
TitlePopulation Neural Activity Mediating Sensory Perception Across Modalities
Investigator
Thomas Robert Clandinin, Surya Ganguli, Mala Murthy, Kristin E Scott
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Natural sensory inputs are typically complex, and often combine multiple modalities. Human speech, for
example, combines auditory signals with visual cues, such as facial expressions, that inform the interpretation
of the spoken words.
TitleQuantifying the role of adaptation in olfactory coding through the logic of navigation
Investigator
Nirag Kadakia
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This project’s long-term goal is a fuller understanding of the neurobiological mechanisms of olfactory sensory
adaptation that facilitate odor discrimination in the natural world.
TitleRAVE: A New Open Software Tool for Analysis and Visualization of Electrocorticography Data
Investigator
Michael S Beauchamp
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique
that allows the activity of small population of neurons in the human brain to be directly recorded.
TitleReadout and control of spatiotemporal neuronal codes for behavior
Investigator
Behtash Babadi, Dante R Chialvo, Tommaso Fellin, Mark H Histed, Patrick O Kanold, Wolfgang Losert, John H.r. Maunsell, Stefano Vt Panzeri, Dietmar Plenz, Dmitry Rinberg, Shy Shoham
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
To survive, organisms must both accurately represent stimuli in the outside world, and use that representation
to generate beneficial behavioral actions.
TitleReal-time statistical algorithms for controlling neural dynamics and behavior
Investigator
Il Memming Park, Jonathan William Pillow
Institute
state university new york stony brook
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
High-throughput experimental neuroscience has made it possible to observe behavior of many
animals, as well as a large groups of neurons simultaneously, providing an exciting opportunity for
figuring out how the neural system performs computations that underlie perception,
TitleRecombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Investigator
James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Understanding brain function and dysfunction requires an understanding of the circuitry of the brain from
molecules to cells to circuits.
TitleRepetitive transcranial ultrasound stimulation for modulating brain rhythms
Investigator
Jacek Dmochowski
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of the proposed research career development program is to allow the applicant to acquire training in
a new form of brain stimulation using ultrasonic waves.
TitleResource for Multiphoton Characterization of Genetically-Encoded Probes
Investigator
Mikhail Drobizhev
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
Two-photon laser scanning microscopy powers many projects in the.
TitleReverse Engineering the Brain Stem Circuits that Govern Exploratory Behavior
Investigator
Martin Deschenes, Yoav Shai Freund, David Golomb, David Kleinfeld, Partha Pratim Mitra, Fan Wang
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Overview - Abstract
Brainstem function is necessary for life-sustaining functions such as breathing and for survival functions,
such as foraging for food. Individual motor actions are activated by specific brainstem cranial motor nuclei.
TitleSpatially Resolved Methylomes to Map Neuronal Cell-Type Connectivity in Tissue
Investigator
Robert Youssefian Henley
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The BRAIN initiative has put forth the development of a neuronal cell-type census as the first step towards
mapping the structure and components of neuronal circuits.
TitleSpatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum
Investigator
David Allenson Borton, Carl Y Saab
Institute
rhode island hospital
Fiscal Year
Funding Opportunities Number
Project Number
Summary/Abstract
Pain is a national health challenge costing our economy more than $600 Billions per year.
TitleSpatiotemporal control of dendritic inhibition by a family of diverse somatostatin-expressing interneurons
Investigator
Bernardo Rudy
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Summary
GABAergic interneurons (INs) are a diverse group of neurons with critical roles in signal processing in the
cerebral cortex. Moreover, malfunction of these neurons has been implicated in a number of diseases ranging
from epilepsy to schizophrenia, anxiety disorders and autism.
TitleStriatal Plasticity in Habit Formation as a Platform to Deconstruct Adaptive Learning
Investigator
Nicole Calakos
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A distinguishing feature of the brain is that its circuitry isn’t computationally static, it adapts to
experience.
TitleStudying perceptual decision-making across cortex by combining population imaging, connectomics, and computational modeling
Investigator
Christopher D Harvey, Wei-Chung Allen Lee, Stefano Vt Panzeri
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
During perceptual decision-making, populations of neurons, arranged in highly interconnected microcircuits,
work together to encode sensory stimuli and to transform sensory perception into appropriate behavioral choices.
A fundamental gap in our knowledge about perceptual decision-ma
TitleSubiculm circuits for cortical feedback regulation of spatial mapping and learning
Investigator
Douglas Arthur Nitz, Xiangmin Xu
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Encoding of environmental location and navigational behavior in mammals involves large ensembles of
specific neuron types across multiple interacting brain regions.
TitleTaking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo
Investigator
Nicole Calakos
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The basal ganglia are critical for the learning and subsequent selection of motor programs. In health,
adaptive plasticity in the basal ganglia enables easy execution of complex motor tasks through
formation of habits.