Project Summary/Abstract
According to the BRAIN 2025 working group report, there is a need to drastically improve the spatiotemporal
resolution of positron emission tomography (PET), in order to facilitate the translation of new tracers that target
neuroreceptor function and dynamic PET imaging on t
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleTechnologies to drastically boost photon sensitivity for brain-dedicated PET
Investigator
Craig S Levin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleThe Application of Generalized Linear Models to Calcium Imaging Data for Optimal High-Dimensional Receptive Field Estimation and Identification of Latent Network Dynamics
Investigator
Stephen L Keeley
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
As new recording methods emerge in neuroscience, new statistical techniques are needed to properly relate
neural activity to behavior, a given stimulus, or an internal process.
TitleTHE DYNAMICS OF LONG RANGE CORRELATIONS IN CORTEX: SINGLE UNITS AND OXYGEN
Investigator
Lawrence H Snyder
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Resting state networks are a fascinating yet poorly understood phenomenon. Sets of spatially
separated regions show correlated slow fluctuations in fMRI BOLD signals, most obvious when
subjects are at rest.
Titlethe self-tuning brain: cellular and circuit mechanisms of behavioral resilience
Investigator
Adrienne L Fairhall, Timothy James Gardner, Carlos Lois
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A major goal in clinical neuroscience is to develop efficient treatments to prevent or minimize the loss of
brain function caused by pathological decreases or increases of neuronal activity, which are hallmarks of a
wide variety of neurological disorders.
TitleTowards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory Replay
Investigator
Gyorgy Buzsaki, John E Lisman, Attila Losonczy, Mark J Schnitzer, Ivan Soltesz
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Although neuroscience has provided a great deal of information about how neurons work, the fundamental
question of how neurons function together in a network to produce cognition has been difficult to address.
Our group has been at the forefront of developing methods that allow large scale monitorin
TitleUnderstanding the synaptic, cellular and circuit events of MEG & EEG using a vertically translational cross-species approach
Investigator
Chengcheng Huang, Dean F Salisbury, Tobias Teichert
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
7. PROJECT SUMMARY
Background. Electro- and magneto-encephalographic (EEG/MEG) responses to a stimulus are systematically
attenuated– by up to 80%– if the same stimulus was presented less than 8-12 seconds ago.
TitleUsing fMRI to Measure the Neural-level Signals Underlying Population-level Responses
Investigator
Rosemary Alice Cowell, David Ernest Huber
Institute
university of massachusetts amherst
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The goal of this proposal is to advance our ability to accurately infer the properties of neu-
ral-level responses from the more coarse-grained information obtained with non-invasive imaging in humans.
To achieve this goal, the project will capitalize on feature-selective cortical r
TitleViral Strategies for Functional Connectomics in the Visual System
Investigator
R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A fundamental but unsolved question in neuroscience is how specific connections between brain cells
(neurons) underlie information processing.
Title"Methods from Computational Topology and Geometry for Analysing Neuronal Tree and Graph Data"
Investigator
Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Progress from description to quantification is essential as a science matures. Yet numerical analysis of the
elementary unit of brain circuitry—the individual neuron—continues to pose methodological challenges.
TitleA unified cognitive network model of language
Investigator
Nathan E Crone, Nitin Tandon
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
Most current approaches to understanding the neural basis of cognitive processes are severely limited in
two respects. First, most commonly used methods do not have the temporal (e.g., fMRI) or spatial (e.g.,
MEG/ EEG) resolution to capture the relevant dynamics.
TitleAdaptive DBS in Non-Motor Neuropsychiatric Disorders: Regulating Limbic Circuit Imbalance
Investigator
Wayne K Goodman
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
In patients with intractable Obsessive-Compulsive Disorder (OCD), ventral striatum (VS) deep brain stimulation
(DBS) effectively reduces symptom severity in about 60% of cases.
TitleBayesian estimation of network connectivity and motifs
Investigator
Dario L Ringach
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The overarching goal of this proposal is to learn how large groups of neurons interact in a network to perform
computations that go beyond the individual ability of each cell.
TitleBeyond Diagnostic Classification of Autism: Neuroanatomical, Functional, and Behavioral Phenotypes
Investigator
Preston Thomas Fletcher
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by repetitive and stereotyped be-
havior and difficulties in communication and social interaction.
TitleBRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain
Investigator
Moo K Chung
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The twin study design in brain imaging offers a very effective way of determining heritability of the human
brain. The difference in variability between monozygotic (MZ) and same-sex dizygotic (DZ) twins can be used
in determining heritability.
TitleChemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD Signal
Investigator
Yen-Yu Ian Shih
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) is widely
used in to study human brain function; however the cellular and molecular mechanisms underlying the BOLD
signal remain poorly understood.
TitleClosed loop deep brain stimulation for Parkinson's disease
Investigator
Philip Andrew Starr
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Deep brain stimulation (DBS) has a major role in the management of movement disorders, and is under
investigation for the treatment of disorders of mood and memory.
TitleClosing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor
Investigator
Kelly D Foote, Aysegul Gunduz
Institute
university of florida
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Essential tremor (ET) is an incurable, degenerative brain disorder that results in increasingly debilitating tremor, and
afflicts an estimated 7 million people in the US (2.2% of the population). While the economic impact of ET is
indeterminate, it is surely quite substantial.
TitleCombined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Investigator
Darin D Dougherty, Alik S Widge
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
This project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD
is a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms
after being treated with medication or talk therapy.
TitleDeep cerebellar electrical stimulation for post-stroke motor recovery
Investigator
Kenneth B Baker, Andre Guelman Machado
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Stroke is a disease of epidemiological proportions in the industrialized world and a leading cause of long-term
disabilities. One third of stroke patients maintain long-term motor deficits severe enough to be disabling,
despite rehabilitative efforts.
TitleDefining Neuronal Circuits and Cellular Processes Underlying Resting fMRI Signals
Investigator
Michael Peter Milham, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
Intrinsic ‘functional connectivity’ (iFC), a measure of correlation between spontaneous fluctuations in the blood
oxygen level dependent (BOLD) signal, reliably distinguish networks of cortical and subcortical areas during
both rest and active task performance.