Project Summary/Abstract
Network methods have emerged as some of the most useful approaches for analyzing functional MRI
data. While great advancements have been made in these methods, limitations hamper the progress fMRI
researchers can make in better understanding brain processes.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNetwork Connectivity Modeling of Heterogeneous Brain Data to Examine Ensembles of Activity Across Two Levels of Dimensionality
Investigator
Kathleen Gates
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural mechanisms and behavioral consequences of non-Gaussian likelihoods in sensorimotor learning
Investigator
Ilya M. Nemenman, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
A central goal of neuroscience is to understand how learning is implemented by the nervous system.
However, despite years of studies in animals and humans, our understanding of both the computational basis
of learning and its implementation by the brain is still rudimentary.
TitleNeuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
Investigator
Matthew A. Howard, John P O'doherty, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Neuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
PIs: Dr. John P. O'Doherty and Dr.
TitleNeurons, Vessels and Voxels: Multi-modal Imaging of Layer Specific Signals
Investigator
Prakash Kara, Thomas P Naselaris, Cheryl A. Olman, Kamil Ugurbil
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Our knowledge of signal processing in various parts of the human brain has been heavily influenced by non-
invasive functional magnetic resonance imaging (fMRI) experiments. FMRI infers the location and selectivity of
neural activity from vascular signals.
TitleNext-Generation Calcium Imaging Analysis Methods
Investigator
Liam M Paninski
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Calcium imaging methods allow us to record the simultaneous activity of many neurons with single-cell
resolution; these methods are therefore a critical enabling tool for the BRAIN initiative and in neuroscience
more broadly.
TitleNoninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's Disease
Investigator
Harrison Carroll Walker
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
It is easy to underestimate the importance of normal movement in daily life, until that ability is altered or taken
away by disease.
TitleNovel Bayesian linear dynamical systems-based methods for discovering human brain circuit dynamics in health and disease
Investigator
Vinod Menon
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Understanding how the human brain produces cognition ultimately depends on precise quantitative
characterization of context-dependent dynamic functional networks (DFN) that transiently link distributed
brain regions.
TitleResting state connectivity: Biophysical basis for and improved fMRI measurements
Investigator
David Kleinfeld, Bruce R Rosen
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Principal Investigators(Last, first, middle):KLEINFELD, DAVID and ROSEN, BRUCE R.
Functional magnetic resonant imaging (fMRI) is the only means to infer neuronal activity within the
entire volume of the human brain.
TitleShort Course in Adaptive Neurotechnologies
Investigator
Gerwin Schalk, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurological disorders affect many millions of people in the United States and throughout the world.
TitleSpatiotemporal signatures of neural activity and neurophysiology in the BOLD signal
Investigator
Shella D Keilholz
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
The blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) fluctuations used to
map functional connectivity contain a wealth of information about neural activity and physiological processes
in the brain.
TitleSubthalamic and corticosubthalamic coding of speech production
Investigator
Robert Mark Richardson
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Speech production and control is disrupted in a number of neurological diseases that involve the basal ganglia.
Notably, hypophonia and hypokinetic dysarthria (characterized by decreased motor gain) are prevalent in
patients with Parkinson's disease (PD).
TitleToward a Theory for Macroscopic Neural Computation Based on Laplace Transform
Investigator
Marc W Howard
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The Weber-Fechner law is perhaps the oldest quantitative relationship in psychology.
TitleUnderstanding evoked and resting-state fMRI through multi scale imaging
Investigator
R Todd Constable, Michael C. Crair, Dewan Syed Fahmeed Hyder
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This RFA is aimed at bringing together interdisciplinary teams to focus on novel, transformative and integrative
efforts that will revolutionize our understanding of the biological and bioinformatics content of the data collected
from non-invasive human functional brain imaging techn
TitleUnderstanding the Neural Basis of Volitional State through Continuous Recordings in Humans
Investigator
Sydney S Cash
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
In the course of a day we naturally make multiple shifts in our overall cognitive state and in our aims and
intents. We go from sleep to awake, from internal dialogue to external communication, from relative immobility
to planned complex movements.
TitleBerkeley Course on Mining and Modeling of Neuroscience Data
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled "Mining and Modeling of Neuroscience Data" which is held at UC Berkeley.
TitleCentral thalamic stimulation for traumatic brain injury
Investigator
Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments.
TitleComputational and circuit mechanisms for information transmission in the brain
Investigator
Uri Tzvi Eden, Loren M Frank, Surya Ganguli, Adam Kepecs, Mark Alan Kramer, Christian Machens, Vanessa Tolosa
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain is a massively interconnected network of regions, each of which contains neural circuits that process information related to combinations of sensory, motor and internal variables.
TitleCoSMo - Summer School in Computational Sensory-Motor Neuroscience
Investigator
Paul R Schrater
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research.
TitleDynamic network computations for foraging in an uncertain environment
Investigator
Dora Angelaki, Valentin Dragoi, Zachary Samuel Pitkow, Paul R Schrater
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain evolved complex recurrent networks to enable flexible behavior in a dynamic and uncertain world, but its computational strategies and underlying mechanisms remain poorly understood.
TitleInterdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
Investigator
Satish S Nair
Institute
university of missouri-columbia
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states.