Funded Awards

PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.

Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.

This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.

This proposal describes a five-year career development program to prepare the candidate, Dr.

PROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu

PROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location.

PROJECT SUMMARY/ABSTRACT An important longstanding goal in neuroscience research is to understand how large-scale spatiotemporal patterns of neural activity emerge in the brain and whether they have a direct role in shaping the brain’s computational processes and thereby mammalian behavior.

In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen

Project Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).

PROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.

Project Summary Many advances in modern neuroscience rely on electrophysiological recordings of large neural populations (e.g. many hundreds of cells) or high-resolution measurements of animal behavior (e.g. from video).

PROJECT SUMMARY Understanding information flow in cortical circuits requires understanding both the anatomical connectivity between neurons and the way in which inputs to a neuron are integrated to generate a spiking output.

ABSTRACT BRAIN Initiative-funded, large-scale approaches to classify neurons based on transcriptomic, morphological and electrical properties have unveiled dozens of unique cell classes in the mouse brain.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative promotes the development and application of technologies to describe the temporal and spatial dynamics of cell types and neural circuits in the brain.

PROJECT SUMMARY Brain image data collected by the neuroscience community will continue to grow dramatically in the next 5-10 years as the push to image physically larger volumes, such as whole brains from humans and other primates, becomes a focus.

Advances in neuroscience depend on robust in vivo and in vitro models with innovative technologies to carry out functional and mechanistic studies accompanied by advanced imaging techniques.

ABSTRACT Perturbations in redox signaling are associated with multiple neurological disorders, ranging from neurodegenerative diseases to brain tumors.

Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters, including the potential to win a fight or prevent escalation resulting in physical injury.

Project Summary Estimates of the total length of axonal "wiring" in the human brain are on the order of hundreds of thousands of kilometers.

Project Summary/Abstract Traumatic brain injury (TBI) is a leading health concern for both children and adults worldwide.