PROJECT SUMMARY
A detailed and comprehensive census of central nervous system (CNS) cell types and states is essential to our
understanding of the neural substrates of cognition and behavior.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleRibo-STAMPEDE: novel tools for molecular profiling of brain cell types
Investigator
Giordano Lippi, Eugene Wei-Ming Yeo
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
TitleRobot assisted brain-wide neural recordings and comprehensive behavioral monitoring in freely behaving mice
Investigator
Timothy J Ebner, Suhasa B Kodandaramaiah
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The brain processes sensory inputs and contextualizes this information with internal brain states, generating the signals that drive motor and cognitive behaviors. The underlying computations are distributed across several anatomically and functionally distinct brain regions.
TitleRole of Endocannabinoid System in Seizure Sensitivity in Eclampsia
Investigator
Maria Jones-Muhammad
Institute
university of mississippi med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Preeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother
displays novel seizures. The mechanisms that cause some preeclampsia patients to advance to
eclampsia are unknown.
TitleRole of neuronal ensembles in cortical plasticity during learning and development
Investigator
Alejandro Akrouh
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar
changes recur throughout life during learning in a more narrowly constrained manner.
TitleScalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease
Investigator
Li Sun
Institute
topogene, inc.
Fiscal Year
Funding Opportunities Number
Project Number
A fundamental goal of the BRAIN Initiative and other neuroscience projects is to map cell types in the brain and study their changes associated with function, disease, and drug treatment.
TitleSecondary analysis of resting state MEG data using the Human Neocortical Neurosolver software tool for cellular and circuit-level interpretation
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The neuroscience community is experiencing a revolution in its ability to share and analyze vast amounts of
human brain imaging data, with support from the BRAIN Initiative and other substantial data-sharing efforts.
TitleSpinal Cord Stimulation to Improve Motor Function in People with Post-Stroke Hemiplegia
Investigator
Marco Capogrosso, Douglas J Weber
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY Motivation: In the US, almost 800’000 people have a stroke every year. Unfortunately, despite intense physio- therapy stroke survivors retain permanent arm motor deficits, some complete hemiparesis.
TitleStatistical machine learning tools for understanding neural ensemble representations and dynamics
Investigator
Uri Tzvi Eden, Loren M Frank, Alan David Kaplan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
The brain is a massively interconnected network of specialized circuits.
TitleSub-millimeter precision wireless neuromodulation using a microwave split ring resonator
Investigator
Ji-Xin Cheng
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet
biomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed
wireless neuromodulation methods.
TitleTargeted Neuromodulation by Nanosecond Pulsed Electric Fields
Investigator
Andrei G Pakhomov
Institute
old dominion university
Fiscal Year
Funding Opportunities Number
Project Number
Nanosecond pulsed electric field (nsPEF) is a new modality for neuromodulation, with unique capabilities
qualitatively different from the conventional electrostimulation.
TitleThe Disadvantage Exposome as a Driver of Alzheimer’s Disease Pathology
Investigator
Margo Heston
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
1 PROJECT SUMMARY
2 Alzheimer's disease (AD) is the most common form of dementia worldwide, incurring a projected healthcare
3 burden of $1 trillion in the United States alone by 2060.
TitleThe Neural Code and Dynamics of the Reading Network
Investigator
Nitin Tandon
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
Reading involves complex transformations of word forms, with visual input mapped to lexical, semantic and
phonological systems in less than a second.
TitleTools for gene editing in marmosets
Investigator
Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Tools for Gene Editing in Marmosets
SUMMARY
The goal of this proposal is to create an efficient new set of tools and techniques for the generation of
genetically modified marmosets suitable for use as models of brain physiology and function.
TitleTwo-photon all-optical electrophysiology in behaving mice
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Two-photon all-optical electrophysiology in behaving mice Neurons communicate through electrical signals, so the ability to record membrane potential from dozens or hundreds of points simultaneously within the brain of a behaving animal would be a transformative capability f
TitleUltra-fast cerebral blood flow imaging for quantifying brain dynamics
Investigator
Jia Guo
Institute
university of california riverside
Fiscal Year
Funding Opportunities Number
Project Number
Abstract/Project Summary
Blood oxygenation level dependent (BOLD) fMRI is widely used in neuroscience studies.
TitleUnderstanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
TitleUnlocking the potential of High-speed widefield Imaging
Investigator
Luke Satish Kumar Theogarajan
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Widefield imaging and spatial multiplexing are crucial to advancing the field of
neuroscience. Current imagers do not offer the speed and versatility needed for
calcium or voltage imaging experiments.
TitleVirtual observatory of the cortex: organelles, cells, circuits, and dynamics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,
Circuits, and Dynamics.
TitleWearable modular high-density diffuse optical tomography
Investigator
Jason Wayne Trobaugh
Institute
esperimage llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
EsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable,
optical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance
imaging (MRI) tools to provide naturalistic brain imaging in adults a
TitleWearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications
Investigator
Lucia Isabel Navarro De Lara
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in
humans.