Abstract
Many scientific efforts have been devoted to understanding the brain functions, and the relevance of its dynamics
during development, aging, and in diseased conditions. Alterations of the brain functions can result from
multifactorial processes and be reflected by various biomarkers.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title3D Functional Photoacoustic Imaging of Human Brain with a Stretchable Ultrasound Matrix Array
Investigator
Yun Jing
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
TitleA community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections
Investigator
Franco Pestilli
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)
community-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool
development.
TitleA Computational Framework for Distributed Registration of Massive Neuroscience Images
Investigator
Matthew Mccormick
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent
advances in imaging data acquisition technologies such as light-sheet fluorescence microscopy (LSFM).
TitleA Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models
Investigator
Guoping Feng
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
While mice are essential models for many areas of neuroscience, there are also many aspects of
higher brain function and dysfunction that cannot be adequately modeled in rodents. Thus, there is a need for
new genetic models that have brain structure and function closer to humans.
TitleA harmonized vendor-agnostic environment for multi-site functional MRI studies
Investigator
Jon-Fredrik Nielsen, Maxim Zaitsev
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-
derstanding of the human brain. Functional MRI may be used to observe brain function during a specific motor
or cognitive task, or at “rest” (resting-state fMRI).
TitleA MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration
Investigator
Janelle Claire Shane
Institute
boulder nonlinear systems, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations
in holographic photostimulation.
TitleA robotic fiber platform for large area deep brain interfacing
Investigator
Itai Cohen, Xiaoting Jia
Institute
virginia polytechnic inst and st univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding the functional network in the brain is critical to the development of neural
prostheses and effective treatment of neurological diseases.
TitleA web-based framework for multi-modal visualization and annotation of neuroanatomical data
Investigator
David Kleinfeld, Samuel Sheng-Hung Wang
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Modern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal
via different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.
Unfortunately, viewing and analysis methods have
TitleAcute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Investigator
Nuri Firat Ince
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
High frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection
area/seizure onset zone (SOZ) in patients with drug resistant epilepsy.
TitleAdaptive optical microscopy for high-accuracy recording of neural activity in vivo
Investigator
Na Ji
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
To understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy,
which requires methodologies with high spatial and temporal resolution.
TitleAdvancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
Investigator
Anton Arkhipov, Emad Tajkhorshid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks
via theory/modeling.
TitleAdvancing brain health research through male germline editing in marmosets
Investigator
Brian Peter Hermann, Jenny Hsieh, John R Mccarrey, Christopher Navara
Institute
university of texas san antonio
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Neuropsychiatric disorders represent a leading cause of disability, affecting nearly 19% of the US population.
Only 9% of neuropsychiatric drugs entering clinical trials reach the market, which is one of the lowest success
rates across all therapeutic areas.
TitleAdvancing Standardization of Neurophysiology Data Through Dissemination of NWB
Investigator
Benjamin K Dichter, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully
extracting return on investment from neurophysiology experiments.
TitleAI based system for longitudinal, repeated measure analyses of freely moving C. elegans worms
Investigator
Jacob R Glaser
Institute
microbrightfield, llc
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This project aims to develop WormInvestigator™, a novel, highly innovative system for performing automated,
high-throughput and longitudinal studies of the behavior of C.
TitleAI-driven biomarker analysis of intact whole brains imaged at micron and sub-micron resolution
Investigator
Katherine Cora Ames, Dominic Mangiardi
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract. Whole-organ 3D immunohistochemistry is revolutionizing the field of neuroscience, enabling
unprecedented insight into the distribution of neural cells and neurological markers throughout the brain in health
and disease.
TitleAn Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species
Investigator
Ting Xu
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows
researchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying
meso- and microscale phenomena that cannot be fully investigated in huma
TitleAn integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition
Investigator
Ziv Williams
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
An integrated single-neuronal, population-, local network- and stimulation-based
prefrontal investigation of human social cognition
This proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-
based evaluation of the role that the dorsal prefrontal co
TitleAnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations
Investigator
Jason M Christie, Adam Hantman, Michael Roland Williams
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A goal of the BRAIN initiative is to develop and validate novel tools to map and manipulate neural circuits. The
definition and control of behaviorally relevant circuits requires both retrograde and anterograde trans-synaptic
technologies that perform well in vivo.
TitleAnticipating ethical challenges and disparities in the dissemination of novel neurotechnologies
Investigator
Winston Chiong, Daniel P. Dohan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for
brain diseases.
TitleBig-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
In an effort to better understand structural organization and anatomy of nervous systems at
unprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have
collected increasingly larger datasets using Electron Microscopy (EM) and X-Ray
Microtomograp