Project Summary
To further our understanding of the function of neural circuits, there is a need for new tools that can
collect simultaneous measurements from large populations of neurons involved in a common neural
computation and provide precise functional modulation.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleDevelopment of 3D-FAST Optical Interface for Rapid Volumetric Neural Sensing and Modulation
Investigator
Emily Gibson, Cristin G Welle
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
TitleDiscovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Understanding the biological principles of cell type diversity and organization is necessary for deciphering
neural circuits underlying brain function.
TitleDisentangling hippocampal and cortical contributions to episodic memory
Investigator
Alexa Tompary
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,
integrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain
stimulation techniques (TMS).
TitleDissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-types
Investigator
Mark J Schnitzer, Ivan Soltesz
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings.
TitleDissecting the role of neuronal-astroglial interactions in sleep homeostasis
Investigator
Ashley Miranda Ingiosi
Institute
washington state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common
in the United States.
TitleEnhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference
Investigator
John Gustaf Wilhelm Samuelsson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Electromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no
implanted hardware or injected biochemical agents.
TitleEthical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study
Investigator
Peter David Zuk
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Brain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions
such as mobility, communication, and visual perception.
TitlefMRI physiological signatures of aging and Alzheimer's Disease
Investigator
Catherine Elizabeth Chang
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new
investigations into functional systems of the human brain.
TitleFrom synapses to genes through morphology: an integrated characterization of cell types based on connectomics and transcriptomics data
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this project is to create a unified framework for understanding the relationship between
neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key
linking modality.
TitleHarmonizing and Archiving of Large-scale Infant Neuroimaging Data
Investigator
Gang Li
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The first postnatal years are an exceptionally dynamic and critical period of structural and functional development
of the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development
during this stage.
TitleHeritability and cognitive implications of structural-functional connectome coupling
Investigator
Amy Kuceyeski
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex
thought, emotion and behavior.
TitleHigh Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging
Investigator
Roger J Zemp
Institute
university of alberta
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Section
Enter the text here that is the new abstract information for your application.
TitleHigh-density optical tomography of cerebral blood flow and metabolism in small animals
Investigator
Guoqiang Yu
Institute
biopticstechnology, llc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Many clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot
maintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to
cerebral ischemic/hypoxic stresses and neurological disorders.
TitleImaging Dynamics in Anxiogenic Serotonin Circuitry
Investigator
Emily Clarissa Wright
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Serotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-
specific dynamics are little understood.
TitleInfluence of task complexity and sensory feedback on cortical control of grasp force
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,
and as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve
and maintain an appropriate grasp force.
TitleIntegration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation
Investigator
Shadi Dayeh
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
We propose to develop novel neurorecording devices using sequential thin-film transistors that are capable of
recording and stimulating brain activity with thousands of channels using only 8 wires and to demonstrate
broadband recordings with large area coverage in fully awake, chronically i
TitleIntegrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources
Investigator
Mark Bender Gerstein, Avram J Holmes
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Constructing an integrated picture of human brain function requires understanding how the effects of molecular
and genetic factors propagate upwards, through many intervening layers of structure and interaction, to
influence behavioral, psychiatric and cognitive traits.
TitleIntegrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks
Investigator
Mikail Rubinov
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Brain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic—
e.g. genomic and transcriptomic—datasets.
TitleInterferometric Speckle Visibility Spectroscopy for Brain Activity Associated Cerebral Blood Flow Monitoring
Investigator
Changhuei Yang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Optical monitoring of brain activities is intrinsically associated with a range of operational advantages:
a. non-ionizing and safe radiation, b. simple and relatively lightweight apparatus, c. readily available
commercial optical advanced systems that can be cross adapted for our usage.
TitleInterrogating the propagation of electrical stimulation across scales in vivo
Investigator
Daniel James Denman
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Intracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in
several animal model systems. However, little is actually known about the ensembles of neurons activated by
typical and clinical intracranial EBS protocols.