ABSTRACT
Micromagnetic stimulation (µMS) has several advantages over electrical stimulation. First, µMS does not
require charge-balanced stimulation waveforms as in electrical stimulation. In µMS, neither sinks nor sources
are present when the time-varying magnetic field induces a current.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleSimultaneous functional MRI and Micro-Magnetic Nervous System Stimulation
Investigator
Ilknur Ay, Giorgio Bonmassar, Xin Yu
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
TitleSimultaneous, Cell-Resolved, Bioluminescent Recording From Microcircuits
Investigator
Nozomi Nishimura, Chris B Schaffer
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Measuring the activity of many individual neurons at once while knowing their wiring diagrams would provide
exciting information on how the components of a network interact.
TitleSmall molecule regulation of endogenous transcription factors for circuit-specific neuromodulation
Investigator
Gerald R. Crabtree
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Methods for regulating cellular processes within distinct populations of neurons are needed to elucidate
relationships between molecular mechanisms, circuits, and behavior; and to develop cell type- or circuit-
selective treatments for neurological disorders.
TitleStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
Investigator
Daniel Lu
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Respiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure
is the leading cause of death in patients with SCI.
TitleStructure and function of spontaneous network activity during circuit formation
Investigator
Arnaldo Carreira-Rosario
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations
during this time can cause lifelong circuit and behavioral changes.
TitleSWITCH trial: Early feasibility study of Stentrode BCI for augmentative communication
Investigator
Nicholas Lachlan Opie, Thomas J Oxley, David Francis Putrino, Douglas J Weber
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary
Multiple early feasibility trials in humans have demonstrated that implantable Brain-Computer Interfaces (BCIs) can enable
people with severe paralysis to use neural signals to control remote and digital communication technologies, including
messaging and email.
TitleThalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome
Investigator
Martha J Morrell
Institute
neuropace, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive
dysfunction and very frequent generalized onset seizures (GOS) often leading to injury.
TitleThe first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases
Investigator
Oliver Graudejus
Institute
bmseed, llc
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The proposed work aims at the development of an enhanced organoid-based in vitro pre-clinical drug
screening platform for neurological and neurodegenerative brain diseases.
TitleThe power of positivity: a novel class of voltage indicators for high-fidelity brain activity imaging
Investigator
Michael Z. Lin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
To understand how the brain functions in health, and how sensory, motor, and cognitive functions are affected in disease, it
is crucial to be able to record the activities of large numbers of individual neurons in real time.
TitleThe representation and modulation of sensory information in the learning and memory center of the Drosophila brain
Investigator
Andrew M Davidson
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses the combined physiology of many cells to transform incoming sensory signals into internal
representations.
TitleThe role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior
Investigator
Sarah D Ackerman
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Significance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.
plasticity) to produce stereotyped behavior.
TitleThin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy
Investigator
Shadi Dayeh
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The goal of this project is to significantly advance the field of acute and semichronic epilepsy monitoring
using novel, high-resolution electrocorticography (ECoG) record/stimulate grids (4096/256 channels,
respectively) and stereoelectroencephalography (sEEG) depth electrodes (120/8 micr
TitleToward functional molecular neuroimaging using vasoactive probes in human subjects
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
We propose to develop a probe technology for monitoring human brain function with molecular precision;
in conjunction with magnetic resonance imaging (MRI) or other imaging modalities, the probes will provide a
combination of sensitivity and resolution that could permit unprecedented noninvasive stu
TitleUltra High-density Optomechanic Neural Interfaces
Investigator
Maysamreza Chamanzar, Gianluca Piazza
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A multi-scale, mechanistic understanding of neural circuits that includes both local- and whole-brain
interconnections still remains elusive.
TitleUltrasonic Genetically Encoded Calcium Indicators for Whole-Brain Neuroimaging
Investigator
Mikhail Shapiro
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
A major goal of the BRAIN initiative is to develop neural imaging technologies enabling whole-brain imaging of
specific molecular signals such as neuronal calcium.
TitleUnderstanding the regulation of neuron cell number and arbor size
Investigator
Jennifer A Malin
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
How the brain generates the correct number of neurons and how these neurons determine the size of their
arbors to innervate the receptor field is a critical question in neurobiology.
TitleUse of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data
Investigator
Marc N Potenza, Yihong Zhao
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Growing up in a media-saturated world, the current generation of children and adolescents spend on average 6-
9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the
USA and elsewhere.
TitleUsing large scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behaviors
Investigator
Kurt M Fraser
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A core feature of a number of psychiatric illnesses is the disordered estimation of the predictive relationship
between a given cue and an outcome. This failure to appraise and generate appropriate behavioral responses
is true for cues that both are rewarding and aversive.
TitleWaking up the nervous system: Molecular characterization of neuronal leader cells and their role in brain development
Investigator
Nicole Ann Aponte-Santiago
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Learning how spontaneous neuronal activity shapes embryonic brain development is critical for understanding
neurodevelopmental processes, with implications in neurological or neuropsychiatric disorders.
Title4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents
Investigator
Russell S Witte
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The overarching goal of this project is to optimize, validate and implement a revolutionary and safe modality
for noninvasive functional imaging of neural currents deep in the human brain through the skull at
unprecedented spatial and temporal resolution.