Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleDecision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleDefining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
TitleDeveloping a novel therapeutic for treating tinnitus
Investigator
Luisa L Scott
Institute
cognosetta, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Tinnitus or “ringing in the ears” is a hearing disorder that disproportionately impacts those who are or have served
in the military. There is currently no effective cure for tinnitus.
TitleDeveloping Molecular and Computational Tools to Enable Visualization of Synaptic Plasticity In Vivo
Investigator
Richard L Huganir
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Developing new methodological and analytical tools to address currently insurmountable experimental questions
is crucial to the future of neuroscience.
TitleDevelopment of multi-color, bright chemigenetic indicators to image synaptic transmission
Investigator
Lin Tian
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Activity of the brain across structures is an orchestrated process that spans a broad range of time
and space scales. Highly coordinated communication is what activate responses to stimuli, makes
behavior possible, and generates memories.
TitleDevelopment of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
TitleDissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
TitleDissemination of 3-photon imaging for chronic cellular imaging across species
Investigator
Jack Waters
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Activity-sensitive fluorescent indicators and microscopy have proven valuable tools for measuring neuronal
activity, but most forms of cellular microscopy can produce images of neurons only near the brain surface and
generally only after removal of tissues overlying the brain surface, such
TitleDopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.
TitleDynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study
Investigator
Marsa Taheri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Astrocytes comprise up to half of mammalian brain cells.
TitleEliminating the human factor from stereotaxic surgeries
Investigator
Achim Klug
Institute
popneuron llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
The main goal of this research project is to develop a new line of new stereotaxic devices for small animal
research that outperforms existing devices in terms of accuracy, reproducibility, and ease of use.
TitleElucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology
Investigator
Takashi Daniel Yoshida Kozai
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an
increasingly prevalent clinical therapy.
TitleEthics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
TitleFocused ultrasound-mediated disruption of blood plasma protein binding with pharmacological molecules
Investigator
Wonhye Lee
Institute
brigham and women's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Region-specific enhancement of drug delivery to the brain, without increasing systemic drug dose or actively
disrupting the blood-brain barrier, has been sought after for effective pharmacological treatment of various
central nervous system disorders.
TitleGeneration of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system
Investigator
Seth Blackshaw
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
New tools are urgently needed to selectively target constructs that monitor and manipulate the activity of
individual cell types without having to rely on genetic manipulation.
TitleGenetic mechanisms specifying astrocyte functional diversity and their role in sleep
Investigator
Margaret Ho
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Astrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our
understanding of their identities and functions is far less comprehensive than for neurons.
TitleGenetic-assisted, full brain scale integrated activity mapping with MRI
Investigator
Mazahir T. Hasan
Institute
achucarro basque center for neuroscience
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
To understand the cellular basis of cognition, behavior and pathology, it is necessary to map the different
participating brain regions and circuits that participate during the different biological processes and do so I the
same animals.
TitleGraspy: A python package for rigorous statistical analysis of populations of attributed connectomes
Investigator
Carey Priebe, Joshua T Vogelstein
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Overview: We will extend and develop implementations of foundational methods for analyzing populations of
attributed connectomes.
TitleHead-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals
Investigator
Vladislav Verkhusha, Junjie Yao
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
To capture the normal brain functions, it is critically important to record the neural activities in freely-behaving
animals, with high resolution, high speed, and high throughput.
TitleHighly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations
Investigator
Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national
Working Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and
generate evidence-based consensus recommendations for the ethical conduct