Project Summary
Individuals decide between alternatives based on their perceived value of the reward associated with each
option.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleHormonal regulation of value-based decision-making
Investigator
Carla Golden
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
TitleIdentifying mediators of sex hormone uptake and signaling
Investigator
Nicole Yishi Leung
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Sex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes
across our lifespan.
TitleImproving Brain Organoid Models by Mediating Metabolic Dysregulation
Investigator
Madeline Andrews
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is currently an unmet need for accurate model systems of the human brain to study its cellular and
molecular features.
TitleInnovative biostatistical approaches to network level analyses of connectome-behavior relationships
Investigator
Muriah D Wheelock
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Determining the mechanisms by which the human brain generates cognition, perception, and emotion hinges
upon quantifying the relationships between coordinated brain activity and behavior.
TitleInter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury
Investigator
Claudia Angeli, Maxwell Boakye
Institute
university of louisville
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY ABSTRACT
More than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000
new cases.
TitleInvestigation of the Cortical Communication (CORTICOM) System
Investigator
Nathan E Crone, Nicolas Franciscus Ramsey
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
For many years brain-computer interfaces (BCI's) have been explored as a means of restoring communication
to patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which
cognition is intact but nearly all motor output from the brain is interrupted, eff
TitlekHz frequency Spinal Cord Stimulation: Novel Temperature-Based Mechanisms of Action
Investigator
Marom Bikson
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
Project(Summary(/(Abstract!
There is a need to understand the mechanisms of neural stimulation technologies (RFA-NS-18-018). The impact
of such research increases with both the clinical relevance of a neuromodulation technology and the extent
mechanisms are unknown.
TitleLarge-field-of-view high-throughput two-photon endoscope to image neuronal activity
Investigator
Weijian Yang
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Large-field-of-view high-throughput two-photon endoscope to image neuronal activity
Development of miniaturized optical endoscopes have enabled visualization and recording of neural activity
in freely-behaving animals.
TitleLarge-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex
Investigator
Jordan Marie Ross
Institute
georgia state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still
maintaining the ability to detect change in the environment is critical to biological success.
TitleLateral habenula circuit in reward/conflict mediation
Investigator
Christian Emmanuell Bravo-Rivera
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Reward is often present in risky environments, requiring individuals to weigh the benefits of rewards against
the associated risks. There are several psychiatric disorders in which patients are unable to choose an
appropriate response during risky reward opportunities.
TitleLight-Induced Targeted Recombination Strategies For Genetic Access to Recently Active Neurons
Investigator
Aaron J Norris, Chandra L Tucker
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A fundamental challenge in neuroscience is in understanding which circuits and cells in the brain contribute to
specific behaviors, perceptions, and functions.
TitleLinking Hippocampal Replay Content to Learning and Decision-Making
Investigator
Michael Edward Coulter
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Memory is an integral component of human cognition, and when memory processes go awry, the result is
devastating neurological disorders of memory loss including Alzheimer's disease and other forms of dementia.
One essential role of normal memory processes is to use previou
TitleLinking molecular and anatomical features of brain cell identity through computational data integration
Investigator
Joshua Welch
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Linking molecular and anatomical features of brain cell identity through computational data integration
Abstract
The brain contains diverse cell types that vary widely in characteristic properties and function in complex,
interconnected circuits.
TitleMagnetic Particle Imaging for High-Resolution Functional Brain Imaging
Investigator
Steven M Conolly
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Magnetic Particle Imaging (MPI) is a novel tomographic imaging modality, with unprecedented contrast,
depth of penetration and sensitivity (1 micromolar sensitivity today; 100 nM soon).
TitleMapping human brain perivascular space in lifespan using human connectome project data
Investigator
Jeiran Choupan
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Perivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble
waste.
TitleMapping the neural circuitry underlying walking
Investigator
Sumaira Zamurrad
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Walking is an essential and conserved behavior across the animal kingdom.
TitleMarkerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
Investigator
Kyle Scott Severson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this proposed research is to reveal the sensory origins underlying the body schema
representation. Body schema is the brain's internal model of the body's spatial configuration.
TitleMassively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
Investigator
Danny Jj Wang, Lihong Wang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT (30 Lines)
The BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation
noninvasive human brain imaging tools and methods that will lead to transformative advances in our
understanding of the human brain.
TitleMaximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordings
Investigator
Loren M Frank, Chong Xie
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
The brain is a massively interconnected network of specialized circuits.
TitleMeasuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan
Investigator
Elizabeth Johnson
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Memory is core to human cognition, undergoes protracted developmental maturation and age-related decline,
and is disrupted in numerous neurological and neuropsychiatric disorders.