PROJECT SUMMARY Within every brain region, neurons can be classified into dozens or hundreds of different cell types, each with unique functional roles and unique impacts on disease states.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology
Investigator
Joshua H Siegle, Karel Svoboda
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Title
NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination
Investigator
Alexander Beckett, David Alan Feinberg, An T Vu
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY The "NexGen" 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe.
Title
Next generation axonal quantification and classification using AI
Investigator
Jacob R Glaser
Institute
microbrightfield, llc
Fiscal Year
Funding Opportunities Number
Project Number
This Phase II project describes the commercial development of HyperAxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional
Title
Next Generation Opto-GPCRs for Neuromodulatory Control
Investigator
Andre Berndt, Michael R Bruchas, Moran Shalev-Benami, Ofer Yizhar
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract: The field of optogenetics — utilizing light to engage biological systems — is widely used for the dissection of neural circuits, cellular signaling and manipulating neurophysiological systems in awake, behaving animals.
Title
Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation
Investigator
Andrei G Pakhomov
Institute
old dominion university
Fiscal Year
Funding Opportunities Number
Project Number
Electrostimulation (ES) is a versatile and efficient tool for interrogating, altering, and manipulating neural activities in health and disease.
Title
O-GlcNac Modulation of GABAergic Transmission
Investigator
Shekinah Phillips
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.
Title
OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.
Title
Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation
Investigator
Lan Luan, Chong Xie
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
Electrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.
Title
Portable Intraoperative MRI for Neurosurgery
Investigator
Hung-Yu Lin
Institute
neuro42, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Magnetic Resonance Imaging (MRI) is the gold-standard method for the detection and diagnosis of brain disease and surgical planning.
Title
Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research
Investigator
Joseph J. Fins, Gabriel Lazaro-Munoz
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI
Title
Postnatal experience shapes gene expression and connectivity development in the cortex
Investigator
Alexander Nevue
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.
Title
Probing form and function of memory representations in the hippocampus of memory expert birds
Investigator
Emily Lambert Mackevicius
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.
Title
Processing of visual information by spatial memory circuits in the avian brain
Investigator
Hannah L Payne
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT. Research Project: Spatial memory – memory of where an event happened or an object was located – depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.
Title
Reconfigurable 3D Origami Probes for Multi-modal Neural Interface
Investigator
Gyorgy Buzsaki, Michael Patrick Flynn, Euisik Yoon
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Over the decades, various neurotechnologies have made significant advancements to meet the highest priority goals enumerated in the BRAIN 2025 Report.
Title
Responsive Neurostimulation for Treatment Resistant Depression
Investigator
Andrew D Krystal
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY This UH3 application seeks to address the major public health burden of treatment-resistant major depression (trMDD) by developing a novel form of Deep Brain Stimulation (DBS).
Title
Role of cortical connections to higher-order thalamic nuclei in visual decision-making
Investigator
Ariana R Andrei
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.
Title
Role of multi-regional neuronal reactivations in reward-based memories
Investigator
Celine Drieu
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.
Title
Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality
Investigator
Gianfranco Doretto, Michael David Morehead, George A Spirou
Institute
istovisr
Fiscal Year
Funding Opportunities Number
Project Number
Over the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.
Title
Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative
Investigator
Kaitlyn Casimo, Jeremy A Miller
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.
Title
Sensing and manipulating neuromodulatory signaling in vivo
Investigator
Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Neuromodulation, such as that mediated by the neuromodulators norepinephrine, acetylcholine, and dopamine, imposes powerful control over brain function. It regulates the excitability, synaptic plasticity, and other aspects of neuronal function.