PROJECT SUMMARY
Technology for recording from the brain is developing at a breakneck pace.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleData interface and apps for systems neurophysiology and imaging
Investigator
Stephen D Van Hooser
Institute
brandeis university
Fiscal Year
Funding Opportunities Number
Project Number
TitleDEEPHIPPO: Ultra-thin lensless endoscope for the visualization of deep hippocampus neuronal functional activity.
Investigator
Herve Rigneault
Institute
aix-marseille university
Fiscal Year
Funding Opportunities Number
Project Number
Rigneault Project Abstract DEEPHIPPO
DEEPHIPPO: Ultra‐thin lensless endoscope for the visualization of deep
hippocampus neuronal functional activity.
Principal investigator: Hervé Rigneault
Host Institution: Aix‐Marseille University, Marseille, France
Project duration : 24 months
Project Abstract
D
TitleDesigning low-cost, customizable high-density probes for acute and chronic neural recordings in rodents
Investigator
Ingrid Van Welie
Institute
neural dynamics technologies inc.
Fiscal Year
Funding Opportunities Number
Project Number
SF424 – Project Summary
Understanding how the brain generates certain behaviors requires an understanding of
the function of individual neurons in dynamical neural circuits.
TitleDevelopment and Translation of an Intracranial Auditory Nerve Implant
Investigator
Robert Kyle Franklin, Thomas Lenarz, Hubert Hyungil Lim, Andrew J. Oxenham, Loren Rieth, Florian Solzbacher
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The proposed project will build and evaluate the safety and design needs of a new type of intracranial auditory
prosthesis that targets the auditory nerve between the cochlea and the brainstem (auditory nerve implant, ANI)
in order to substantially improve hearing performance over the curre
TitleDevelopment of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the positron emission tomography (PET) detector module for the next
generation 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved
spatio-temporal resolution.
TitleDevelopment of a Revolutionary MRI System for Functional Brain Imaging
Investigator
Bob S Wagner, Sou-Tien Bert Wang
Institute
wang nmr, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
It is the dream of researcher's and clinician's to have available a low cost, portable MRI scanner for brain
neuroimaging. However, such a low cost MRI system requires a small bore MRI magnet.
TitleDissecting corticostriatal circuitry underlying chronic binge eating
Investigator
Britny Hildebrandt
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Eating disorders are severe psychiatric conditions with a significant worldwide cost and disability burden. Binge
eating (BE) is a behavior that cuts across nearly all eating disorder diagnoses.
TitleDual-channel Sub-millisecond Resolution Neural Imaging System
Investigator
Youbo Zhao
Institute
physical sciences, inc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The investigation of the complex neural dynamics and the cognitive functions of the brain requires non-
invasive recording tools with high spatio-temporal resolution.
TitleDynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks
Investigator
Gerwin Schalk
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Improved understanding of the brain processes underlying normal and abnormal function is necessary for
devising better ways to diagnose, alleviate, or cure neurological or psychiatric disorders.
TitleEarly Feasibility Clinical Trial of a Visual Cortical Prosthesis
Investigator
Jessy D Dorn, Robert Jay Greenberg, Nader Pouratian
Institute
second sight medical products, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Blindness in the United States is a large and increasing problem. Any significant vision loss is
debilitating, but profound blindness is devastating to an individual’s ability to be independent
and to perform everyday tasks and activities.
TitleEnabling Multi-Tracer SPECT Studies of the Human Brain
Investigator
Todd E Peterson
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Molecular imaging provides the means to quantitatively study many types of processes in the human brain in a
minimally invasive manner.
TitleEpigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cells
Investigator
Andrew Adey
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The mammalian brain is an enormously complex organ with myriad cell types cohesively working together to
carry out a host of intricate tasks, from motor functions, to the storing and execution of consciousness.
TitleFast Spatial Light Modulators for Neuronal Excitation and Imaging
Investigator
Andrei Faraon
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: We propose to develop fast spatial light modulators (SLM) to address the
need for optical hardware compatible with the current fast genetically encoded sensors and
actuators.
TitleFast volumetric imaging of large areas in deep brain
Investigator
Timothy Holy
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
One of the central goals of the BRAIN initiative is to develop and disseminate methods for
imaging activity in large populations of neurons at high speeds. Of the available techniques,
one of the most promising is light sheet microscopy.
TitleFlatScopes for Implantable and Scalable Optical Imaging of Neural Activity
Investigator
Caleb Kemere, Jacob T. Robinson, Ashok Veeraraghavan
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Large-scale measurement of individual neuronal activity in intact animals will accelerate the understanding of
the brain and treatment of neurological disorders.
TitleFOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATION
Investigator
Hong Chen
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Although neurotechnologies are rapidly advancing, we lack a noninvasive, cell-type specific, and
spatiotemporally regulated neuromodulation tool, which would radically change neuroscience research and
enable clinically noninvasive brain stimulation with high spatiotemporal p
TitleHigh SNR Functional Brain Imaging using Oscillating Steady State MRI
Investigator
Douglas C Noll
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: High SNR Functional Brain Imaging using Oscillating Steady State MRI
Functional brain imaging using MRI (functional MRI or fMRI) has grown rapidly over the past 25 years and is
widely used for basic cognitive neuroscience research and for presurgical planning.
TitleHigh speed, high precision volumetric multiphoton neural control
Investigator
Hillel Adesnik
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Large scale manipulation of neural ensemble activity at cellular resolution and millisecond precision is a major
technological goal of the BRAIN initiative.
TitleHigh-throughput 3D random access three-photon calcium imaging
Investigator
Meng Cui
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
High-throughput 3D random access three-photon structural and functional imaging
Two-photon microscopy allows in vivo observation of neuronal dynamics at high spatial and temporal
resolutions.
TitleHuman Agency and Brain-Computer Interfaces: Understanding users’ experiences and developing a tool for improved consent
Investigator
Sara Goering, Eran Klein
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neural prosthetic devices for sensorimotor and psychiatric disorders are in development as a
priority area of the BRAIN Initiative yet they raise important ethical concerns about human
agency.