Funded Awards

Project Abstract Current common methods for measuring somatosensory function in preclinical rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli.

PROJECT SUMMARY/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.

There is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).

Essential tremor (ET) is a common neurologic disorder affecting over 10 million people in the United States. Pathologic synchrony in the cerebello-thalamo-cortical (CTC) network has been considered to underlie the development of ET.

PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.

Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.

This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.

Project Summary Multiplexed imaging of brain cells and tissues can reveal critical details about the abundance and spatial organization of molecular targets.

This proposal describes a five-year career development program to prepare the candidate, Dr.

Abstract The human brain is estimated to contain over 100 billion neurons that are wired together by more than 100 trillion synapses.

In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen

Optical monitoring of brain activities is intrinsically associated with various operational advantages, including low-cost and portable noninvasive bedside continuous monitoring capabilities.

Project Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).

PROJECT SUMMARY Poor sleep is common in neurodevelopment disorders such as autism spectrum disorder (ASD), with up to 93% of ASD individuals reporting sleep problems.

The goal of this project is to develop a Wireless, fully Implantable, bidirectional Cortical Neuroprosthetic System (W-ICONS) for restoring sensorimotor function through an interface with intact upper limb areas of primary motor and sensory cortex.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative promotes the development and application of technologies to describe the temporal and spatial dynamics of cell types and neural circuits in the brain.

PROJECT SUMMARY Brain image data collected by the neuroscience community will continue to grow dramatically in the next 5-10 years as the push to image physically larger volumes, such as whole brains from humans and other primates, becomes a focus.

Abstract An outstanding challenge of brain research is to link the cross-scale functional perspectives from the cellular and molecular level to the circuit and systems level.

Implantable interfaces for neuromodulation is necessary to advance fundamental neuroscience research, develop new treatments for neurological disorders, and create efficient breakthrough neuroprosthetics. However, modern implants based on multi-electrode arrays suffer from low spatial resolution, hi

Abstract Among the BRAIN Initiative’s most important achievements are the genetic identification of many new neurons- types and the creation of genetic tools to access these cell types.