Project Summary/Abstract
Memory impairment occurs in a variety of neuropsychiatric conditions (e.g., depression and schizophrenia) and
in many neurologic disorders (e.g., neurodegenerative disease and brain injury), often with devastating
consequences for life quality.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleOptimized dosing of repetitive transcranial magnetic stimulation for enhancement of hippocampal-cortical networks
Investigator
Joel L Voss
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
TitleOptimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodes
Investigator
Bijan Pesaran, John Rogers, Kenneth L Shepard, Jonathan Viventi
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
In this proposal, we will develop next-generation flexible micro-electrocortigraphic (µECoG) and penetrating
electrode arrays using active electronics in complementary metal-oxide-semiconductor (CMOS) technology.
Active electronics enable amplification and multiplexing directly at each ele
TitleOptimizing peripheral stimulation parameters to modulate the sensorimotor cortex for post-stroke motor recovery
Investigator
Karunesh Ganguly
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Stroke is the leading cause of disability in the United States, with approximately 700,000 new cases per
year. Disability from upper limb impairment depends primarily on loss of hand function and finger
dexterity.
TitleQuiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System
Investigator
Angel V Peterchev
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
This project will develop a low-noise transcranial magnetic stimulation (TMS) system. TMS is a technique
for non-invasive brain stimulation using strong, brief magnetic pulses. TMS is widely used as a tool for probing
brain function and is an FDA approved treatment for depression.
TitleRapid Electrode Multiplexing for Scalable Neural Recording
Investigator
Ross M Walker
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Rapid Electrode Multiplexing for Scalable Neural Recording
Large-scale recording of neural signals is essential for gaining a better understanding of the elaborate, dynamic
picture of the brain that emerges from interactions involving individual cells and complex neural circuits.
TitleRational Optimization of tACS for Targeting Thalamo-Cortical Oscillations
Investigator
Flavio Frohlich
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH
The alpha oscillation is a thalamo-cortical rhythm (8-12 Hz) that serves important functional roles in
cognition and behavior.
TitleShort Course in Adaptive Neurotechnologies
Investigator
Gerwin Schalk, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurological disorders affect many millions of people in the United States and throughout the world.
TitleSpatiotemporal control of large neuronal networks using high dimensional optimization
Investigator
Shinung Ching, Jr-Shin Li, Jason T Ritt
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The long terms goal of this project is to enable the control of large networks in the brain using neurostimulation
technologies, a key focus of the BRAIN initiative.
TitleStructure guided design of photoselectable channelrhodopsins
Investigator
Vadim Cherezov, Samuel Andrew Hires, Vsevolod Katritch, John Yu-Luen Lin
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
This proposal outlines the development of a fundamentally new optogenetic technology capable
of flexibly manipulating the activity of thousands of neurons contributing to the dynamic activity
of distributed neural circuits with single neuron resolution.
No method that currently exis
TitleSubthalamic and corticosubthalamic coding of speech production
Investigator
Robert Mark Richardson
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Speech production and control is disrupted in a number of neurological diseases that involve the basal ganglia.
Notably, hypophonia and hypokinetic dysarthria (characterized by decreased motor gain) are prevalent in
patients with Parkinson's disease (PD).
TitleTowards deep brain monitoring with superficial EEG sensors plus neuromodulatory focused ultrasound
Investigator
Pierre D Mourad
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Electrical activity in the brain is a direct correlate to neuronal activity. Existing technology can record
electrical activity on a millisecond scales through invasive placement of electrodes within the brain or non-
invasively, using subdermal electrodes.
TitleUnderstanding the Neural Basis of Volitional State through Continuous Recordings in Humans
Investigator
Sydney S Cash
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
In the course of a day we naturally make multiple shifts in our overall cognitive state and in our aims and
intents. We go from sleep to awake, from internal dialogue to external communication, from relative immobility
to planned complex movements.
TitleWearable Transcranial Focused Ultrasound System for Region-specific Functional Neuromodulation
Investigator
Seung-Schik Yoo
Institute
brigham and women's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The main objective of the proposed research is to develop a wearable transcranial focused ultrasound
(tFUS) environment that reversibly modulates (either elicits or suppresses) region-specific neural
activities of the brain.
TitleWide deployment of massively multiplexed nanosystems for brain activity mapping
Investigator
Michael L Roukes, Kenneth L Shepard
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
This project will place into the hands of many experimental neuroscientists validated, massively-multiplexed tools
for recording of neuronal activity, for chemical sensing of neuromodulators, and for highly-patterned optogenetic
stimulation with concurrent electrical recording – in any region of the
TitleWireless Photometry For In Vivo Behavorial Studies
Investigator
Paul Braun, Michael R Bruchas
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The goal of this R21 proposal is to develop a robust, minimally invasive wireless photometry
system for in vivo calcium measures in freely moving behavior.
TitleWireless recording in the central nervous system with ultrasonic neural dust
Investigator
Jose Miguel Carmena
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
We propose an ultra-miniature as well as extremely compliant system that enables massive scaling in the
number of neural recordings from the brain while providing a path towards large-scale neural recordings and
truly chronic brain-machine interfaces (BMI).
TitleA novel approach to examine slow synaptic transmission in vivo
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Two primary modes of chemical communication occur between neurons in the brain: fast synaptic transmission, such as that mediated by glutamate and GABA, which directly control the electrical activities of neurons, and slow synaptic transmission, such as tha
TitleA robust ionotropic activator for brain-wide manipulation of neuronal function
Investigator
Andrew D Ellington, Boris V Zemelman
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal embodies the rational design, high throughput screening, and in vitro characterization of novel neuronal actuators. The starting point for our endeavor is an ionotropic channel that launched the optogenetic revolution.
TitleA viral system for light-dependent trapping of activated neurons
Investigator
Michael R Drew, Stephen Martin, Boris V Zemelman
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A central goal in neuroscience is to identify cellular ensembles supporting mental and behavioral states, but these ensembles cannot be defined a priori.
TitleBerkeley Course on Mining and Modeling of Neuroscience Data
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled "Mining and Modeling of Neuroscience Data" which is held at UC Berkeley.