DESCRIPTION (provided by applicant): Transitioning from small numbers of neural depth recording electrodes to many thousands requires consideration not only of data management, but also how to non-destructively deliver these electrodes into the desired brain regions.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleSelf-Motile Electrodes for Three Dimensional, Non-perturbative Recording and Stimulation
Investigator
Nicholas A Melosh
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleSonoelectric tomography (SET): High-resolution noninvasive neuronal current tomography
Investigator
Matti Hamalainen, Partha Pratim Mitra, Nathan J. Mcdannold, Yoshio Okada
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Presently there is no imaging technology capable of detecting neuronal activity in the entire human brain with millisecond and millimeter resolution.
TitleSpace-division multiplexing optical coherence tomography for large-scale, millisecond resolution imaging of neural activity
Investigator
Yevgeny Berdichevsky, Chao Zhou
Institute
lehigh university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION There is a great interest in imaging neuronal activity based on changes in fast intrinsic optical signals (e.g. changes in light scattering and phase) that occur on a millisecond timescale.
TitleToward functional molecular neuroimaging using vasoactive probes in human subjects.
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The establishment of new and precise strategies for mapping brain activity in human subjects is one of the highest priorities of the BRAIN Initiative.
TitleUltra-miniaturized single fiber probe for functional brain imaging in freely moving animals
Investigator
Jerome Mertz
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Microscope techniques to image inside brain tissue are generally limited by poor depth penetration.
TitleUse of Calcium Indicator Proteins in Spike Counting Mode
Investigator
David A Digregorio, Samuel Sheng-Hung Wang
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A long-term goal of the BRAIN Initiative is to track activity in large numbers of neurons individually in behaving animals, thus capturing the information processing that is done by brain circuitry.
TitleVirtual Brain Electrode (VIBE) for Imaging Neuronal Activity
Investigator
Jeff W Bulte
Institute
hugo w. moser res inst kennedy krieger
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A technique will be developed to determine where in the brain the signal in an electroencephalogram (EEG) is originating from in order to generate a "voxel-specific EEG", much like the signal coming from an implanted electrode.
TitleWavefront sensor for deep imaging of the brain
Investigator
Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Optical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges for optical brain imaging are depth and speed.
TitleAdvancing MRI & MRS Technologies for Studying Human Brain Function and Energetics
Investigator
Wei Chen, Qing X Yang
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Magnetic resonance (MR) imaging (MRI) and in vivo MR spectroscopy (MRS) techniques have become indispensable tools for imaging brain structure, function, connectivity, neurochemistry and neuroenergetics, and for investigating neurological disorders.
TitleBehavioral readout of spatiotemporal codes dissected by holographic optogenetics
Investigator
Dmitry Rinberg, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by the activity of neurons at different levels of information processing?
TitleCalcium sensors for molecular fMRI
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The development of minimally invasive direct readouts of neural activity is one of the greatest challenges facing neuroscience today.
TitleCortical circuits and information flow during memory-guided perceptual decisions
Investigator
Mriganka Sur
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Perceptual decision-making involves multiple cognitive components and diverse brain regions.
TitleCrowd coding in the brain:3D imaging and control of collective neuronal dynamics
Investigator
Patrick O Kanold, Wolfgang Losert, Dietmar Plenz
Institute
univ of maryland, college park
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The cortex is a laminated structure that is thought to underlie sequential information processing.
TitleDevelopment of Protein-based Voltage Probes
Investigator
Vincent A Pieribone
Institute
john b. pierce laboratory, inc.
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The use of genetically encoded fluorescent activity probes represent the most advanced method to monitor the electrical activity of networks of neurons without using electrodes.
TitleDissecting human brain circuits in vivo using ultrasonic neuromodulation
Investigator
Mikhail Shapiro, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A dream of neuroscience is to be able to non-invasively modulate any given region of the human brain with high spatial resolution.
TitleFAST HIGH-RESOLUTION DEEP PHOTOACOUSTIC TOMOGRAPHY OF ACTION POTENTIALS IN BRAINS
Investigator
Lihong Wang
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Revealing how our brain works is a great challenge but yet worth our every effort: it will not only illuminate the profound mysteries in science but also provide the key to understanding and treating neurological diseases such as Alzheimer's and Parkinson's
TitleGenetically encoded reporters of integrated neural activity for functional mapping of neural circuitry
Investigator
Kit S Lam, James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): One of the major challenges in neuroscience is to link the structure to the function of neural circuits.
TitleGenetically encoded sensors for the biogenic amines: watching neuromodulation in action
Investigator
Lin Tian
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of this proposal is to develop a toolbox of genetically encoded indicators for biogenic amines, the most important family of neuromodulators.
TitleHigh-Density Recording and Stimulating Microelectrodes
Investigator
Timothy James Gardner
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This project seeks to develop a high density, minimally invasive electrode array for long-term recording and control of brain activity.
TitleImaging Brain Function in Real World Environments & Populations with Portable MRI
Investigator
Michael Garwood, John T Vaughan
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) continues to play a critical role in understanding the human brain.