Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNetwork based neuro-modulation for mesial temporal lobe epilepsy
Investigator
Behnaam Aazhang, Sandipan Pati Bankim Behari Pati, Nitin Tandon, Gregory A Worrell
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural mechanisms of behavioral coordination in Hydra
Investigator
Alison Hanson
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How do animals coordinate their many parts to generate coherent, adaptive behavior?
TitleNeuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin Optoelectronic Materials
Investigator
Ertugrul Cubukcu
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin
Optoelectronic Materials
Recording electrical activity of neural populations with high resolution is essential to
investigate neural circuits and cognitive functions.
TitleNEURODEVELOPMENTAL FUNCTION OF HCFC1
Investigator
Victoria L Castro
Institute
university of texas el paso
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin
metabolism, intractable epilepsy, intellectual disability, and motor dysfunction.
TitleNeurodevelopmental role of a tRNA methyltransferase underlying intellectual disability
Investigator
Kimberly Rose R. Madhwani
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Gene regulation at multiple levels is critical for nervous system development and function.
TitleNeurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson's disease
Investigator
Helen Bronte-Stewart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Cognitive decline begins in early stages of Parkinson’s disease (PD) and progresses to dementia in 75% of
people with PD after ten years.
TitleNew Methodologies for Connectomics
Investigator
Xiaotang Lu
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT ABSTRACT
The nervous systems of animals are comprised of neurons connected by a large number of synapses.
The resulting neural networks underlie animal behavior and contribute to the storage of learned
information in many species.
TitleNoninvasive Targeted Neuromodulation
Investigator
Jan Kubanek
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Neurological and psychiatric disorders absorb one-third of the total health care expenditures; more than cancer, cardiovascular diseases, and diabetes combined. On average, approximately one in three patients fails to respond to medication treatments or has intolerable side effects.
TitleONIX: A Neural Acquisition System for Unencumbered, Closed-Loop Recordings in Small, Freely Moving Animals
Investigator
Jonathan Newman
Institute
open ephys, inc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Over the last century, extracellular recording technologies have progressed from handmade needle electrodes
and vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip
digitization circuits.
TitleOpen-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging
Investigator
Daniel Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman Golshani, Alcino J. Silva, Alipasha Vaziri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Single-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors
has allowed investigators to record the activity of large populations of identified neurons over days to weeks in
freely behaving animals, answering fundamental questions in neurosci
TitleOptical neural motes to enable high density recording through intact dura in a nonhuman primate
Investigator
David Blaauw, Cynthia Anne Chestek
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless
Motes for Large Scale Implantation Into Nonhuman Primate Cortex
In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes
near-infrared (NIR) light for
TitleOptical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation
Investigator
Xue Han
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes.
TitleOptimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures
Investigator
Meng Cui, Scott M Sternson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A central goal of neuroscience is to understand animal behavior in the context of the information processing properties of neuron ensembles.
TitleOptimization of Flexible Neural Probe Arrays for Multi-Region Recordings in Rodents and Nonhuman Primates
Investigator
Ellis Meng, Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
A core goal of the BRAIN Initiative is to link neural activity to behavior which requires technology to acquire high-quality recordings of dynamic neural activity from different brain regions over time.
TitleOptimization, application, and dissemination of imaging modules for high-speed mesoscopic volumetric recording of neuroactivity in scattering brains
Investigator
Alipasha Vaziri
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A number of recent observations suggest that complex brain functions in the mammalian brain emerge from highly parallel computation in which information about sensory inputs, internal states, and behavioral parameters are mapped onto highly distributed brain-wide neuronal
TitleOrganic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)
Investigator
Dion Khodagholy
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A major obstacle to understanding how the dynamic activity of brain circuits permits the emergence of cortical function is the insufficient capability to acquire and manipulate this activity across the course of brain maturation.
TitlePinpointing the Cerebellum's Contribution to Social Reward Processing
Investigator
Haroon Skander Popal
Institute
temple univ of the commonwealth
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum has long been thought to solely process motor information. Yet, there is a growing literature
that points to a role of the cerebellum in processes across multiple domains.
TitleProtein ticker-tapes for brain-wide neural recordings
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Protein ticker-tapes for brain-wide neural recordings
Behavior emerges from the interacting activity of widely distributed ensembles of neurons; but all existing tools
for measuring brain activity sample only a small subset of these dynamics.
TitleRapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light source
Investigator
Kim Butts-Pauly, Xiaoke Chen, Guosong Hong
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Optogenetics provides a precise deconstruction of neural circuits by optically manipulating the activity of opsin-expressing neurons with fast temporal responses and neuron-type specificity.
TitleReal Time NEURON Simulation for Experimental Applications
Investigator
Mark W Nowak
Institute
cytocybernetics, inc.
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this proposal is to combine the power of the NEURON mathematical modeling software with the Cybercyte “plug and play” dynamic clamp system.