PROJECT SUMMARY/ABSTRACT
Two-photon all-optical electrophysiology in behaving mice Neurons communicate through electrical signals, so the ability to record membrane potential from dozens or hundreds of points simultaneously within the brain of a behaving animal would be a transformative capability f
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleTwo-photon all-optical electrophysiology in behaving mice
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
TitleUltra-fast cerebral blood flow imaging for quantifying brain dynamics
Investigator
Jia Guo
Institute
university of california riverside
Fiscal Year
Funding Opportunities Number
Project Number
Abstract/Project Summary
Blood oxygenation level dependent (BOLD) fMRI is widely used in neuroscience studies.
TitleUltrafast high-contrast voltage imaging in freely moving animals
Investigator
Jerome Mertz
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
We propose to develop a targeted illumination confocal (TICO) microscope to enable high speed,
large-scale voltage imaging in the brain. This microscope will be based on the combination of two
key strategies. The first strategy is high-speed confocal microscopy based on line scanning.
TitleUnderstanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
TitleUnlocking the potential of High-speed widefield Imaging
Investigator
Luke Satish Kumar Theogarajan
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Widefield imaging and spatial multiplexing are crucial to advancing the field of
neuroscience. Current imagers do not offer the speed and versatility needed for
calcium or voltage imaging experiments.
TitleVirtual observatory of the cortex: organelles, cells, circuits, and dynamics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,
Circuits, and Dynamics.
TitleWearable modular high-density diffuse optical tomography
Investigator
Jason Wayne Trobaugh
Institute
esperimage llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
EsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable,
optical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance
imaging (MRI) tools to provide naturalistic brain imaging in adults a
TitleWearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications
Investigator
Lucia Isabel Navarro De Lara
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in
humans.
Title3D Functional Photoacoustic Imaging of Human Brain with a Stretchable Ultrasound Matrix Array
Investigator
Yun Jing
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Many scientific efforts have been devoted to understanding the brain functions, and the relevance of its dynamics
during development, aging, and in diseased conditions. Alterations of the brain functions can result from
multifactorial processes and be reflected by various biomarkers.
TitleA community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections
Investigator
Franco Pestilli
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)
community-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool
development.
TitleA Computational Framework for Distributed Registration of Massive Neuroscience Images
Investigator
Matthew Mccormick
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent
advances in imaging data acquisition technologies such as light-sheet fluorescence microscopy (LSFM).
TitleA harmonized vendor-agnostic environment for multi-site functional MRI studies
Investigator
Jon-Fredrik Nielsen, Maxim Zaitsev
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-
derstanding of the human brain. Functional MRI may be used to observe brain function during a specific motor
or cognitive task, or at “rest” (resting-state fMRI).
TitleA MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration
Investigator
Janelle Claire Shane
Institute
boulder nonlinear systems, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations
in holographic photostimulation.
TitleA robotic fiber platform for large area deep brain interfacing
Investigator
Itai Cohen, Xiaoting Jia
Institute
virginia polytechnic inst and st univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding the functional network in the brain is critical to the development of neural
prostheses and effective treatment of neurological diseases.
TitleA Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.
Investigator
Jeff W Lichtman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The goal of this work is to facilitate synaptic level analysis of neurons and their interconnecting microcircuits in
neurosurgical cerebral cortex biopsies from human patients.
TitleA web-based framework for multi-modal visualization and annotation of neuroanatomical data
Investigator
David Kleinfeld, Samuel Sheng-Hung Wang
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Modern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal
via different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.
Unfortunately, viewing and analysis methods have
TitleAcute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Investigator
Nuri Firat Ince
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
High frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection
area/seizure onset zone (SOZ) in patients with drug resistant epilepsy.
TitleAdaptive optical microscopy for high-accuracy recording of neural activity in vivo
Investigator
Na Ji
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
To understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy,
which requires methodologies with high spatial and temporal resolution.
TitleAdvancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
Investigator
Anton Arkhipov, Emad Tajkhorshid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks
via theory/modeling.
TitleAdvancing Standardization of Neurophysiology Data Through Dissemination of NWB
Investigator
Benjamin K Dichter, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully
extracting return on investment from neurophysiology experiments.