Abstract
This project aims to develop WormInvestigator™, a novel, highly innovative system for performing automated,
high-throughput and longitudinal studies of the behavior of C.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleAI based system for longitudinal, repeated measure analyses of freely moving C. elegans worms
Investigator
Jacob R Glaser
Institute
microbrightfield, llc
Fiscal Year
Funding Opportunities Number
Project Number
TitleAI-driven biomarker analysis of intact whole brains imaged at micron and sub-micron resolution
Investigator
Katherine Cora Ames, Dominic Mangiardi
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract. Whole-organ 3D immunohistochemistry is revolutionizing the field of neuroscience, enabling
unprecedented insight into the distribution of neural cells and neurological markers throughout the brain in health
and disease.
TitleAn Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species
Investigator
Ting Xu
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows
researchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying
meso- and microscale phenomena that cannot be fully investigated in huma
TitleAn integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition
Investigator
Ziv Williams
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
An integrated single-neuronal, population-, local network- and stimulation-based
prefrontal investigation of human social cognition
This proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-
based evaluation of the role that the dorsal prefrontal co
TitleAnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations
Investigator
Jason M Christie, Adam Hantman, Michael Roland Williams
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A goal of the BRAIN initiative is to develop and validate novel tools to map and manipulate neural circuits. The
definition and control of behaviorally relevant circuits requires both retrograde and anterograde trans-synaptic
technologies that perform well in vivo.
TitleAnticipating ethical challenges and disparities in the dissemination of novel neurotechnologies
Investigator
Winston Chiong, Daniel P. Dohan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for
brain diseases.
TitleBig-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
In an effort to better understand structural organization and anatomy of nervous systems at
unprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have
collected increasingly larger datasets using Electron Microscopy (EM) and X-Ray
Microtomograp
TitleBRAIN Initiative: Assessing development of event-related cortical network dynamics
Investigator
Scott Makeig, Michael Peter Milham, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The Child Mind Institute’s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and
sharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children
and adolescents (ages 5-21).
TitleBRAIN Viral Vector Services and Distribution Core
Investigator
Kimberly Ritola
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,
propagation, and distribution of viral vectors that are used by neuroscientists for neural circuit
identification and manipulation, as well as for preclinical translational studies.
TitleBRAINShare: Sharing Data in BRAIN Initiative Studies
Investigator
Amy L Mcguire, Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Data sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN
Initiative.
TitleCell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Investigator
Anton Arkhipov, Li-Huei Tsai
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,
typically employing periodic light flicker or auditory tones presented at regular intervals.
TitleCellular and Neural Network Mechanism of Transcranial Electric Stimulation
Investigator
Dominique M Durand
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006).
TitleCellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex
Investigator
Padmavathi Sundaram Patel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)
may activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro
turtle Cb, (ii) computational modeling of the induced electric (E) fields in the
TitleCharacterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound
Investigator
Bin He
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures.
TitleCircuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation
Investigator
Alik S Widge
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders.
TitleClinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging
Investigator
Raag D Airan
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY .
There are numerous clinical needs for a technology that can modulate nervous system activity noninvasively
and focally, with clinically-relevant spatial and temporal precision, with a robust and predictable mechanism of
action, and that could act on any of the varied modes of neura
TitleComputational neuroscience of language processing in the human brain
Investigator
Evelina Fedorenko, Robert Mark Richardson
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
TitleConformable, Expandable Neural Interface Device for the developing brain
Investigator
Jennifer Gelinas, Dion Khodagholy
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A major obstacle to identifying neural network mechanisms responsible for emergence of cognitive function is
insufficient capability to acquire large-scale electrophysiologic signals across the course of brain maturation.
There is urgent need to develop the technology and ex
TitleConnecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression
Investigator
Alex Leow, Yichao Wu, Liang Zhan
Institute
university of illinois at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Recently, several lines of evidence have supported that synaptic dysfunction represents one of
the earliest brain changes in Alzheimer’s disease (AD), leading to hyper-excitation in neuronal
circuits.
TitleControl of the time course of dopamine release through optimized electrical brain stimulation.
Investigator
Stephen Leigh Cowen, Michael L Heien, Timothy Lewis
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical stimulation of deep brain structures is an essential tool for the causal investigation of neural systems
that regulate learning and decision making.