Project Summary/Abstract Section
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Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleHigh Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging
Investigator
Roger J Zemp
Institute
university of alberta
Fiscal Year
Funding Opportunities Number
Project Number
TitleHigh-density optical tomography of cerebral blood flow and metabolism in small animals
Investigator
Guoqiang Yu
Institute
biopticstechnology, llc
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Many clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot
maintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to
cerebral ischemic/hypoxic stresses and neurological disorders.
TitleImaging Dynamics in Anxiogenic Serotonin Circuitry
Investigator
Emily Clarissa Wright
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Serotonin has been long been recognized as an important modulator of mood and behavior, yet it projection-
specific dynamics are little understood.
TitleInfluence of task complexity and sensory feedback on cortical control of grasp force
Investigator
Jennifer L. Collinger
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Humans can skillfully control their grasp during actions as complex and dynamic as swinging a tennis racket,
and as simple and static as holding a briefcase. Both tasks require the use of sensory feedback to achieve
and maintain an appropriate grasp force.
TitleIntegration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation
Investigator
Shadi Dayeh
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
We propose to develop novel neurorecording devices using sequential thin-film transistors that are capable of
recording and stimulating brain activity with thousands of channels using only 8 wires and to demonstrate
broadband recordings with large area coverage in fully awake, chronically i
TitleIntegrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources
Investigator
Mark Bender Gerstein, Avram J Holmes
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Constructing an integrated picture of human brain function requires understanding how the effects of molecular
and genetic factors propagate upwards, through many intervening layers of structure and interaction, to
influence behavioral, psychiatric and cognitive traits.
TitleIntegrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networks
Investigator
Mikail Rubinov
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Brain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic—
e.g. genomic and transcriptomic—datasets.
TitleInterferometric Speckle Visibility Spectroscopy for Brain Activity Associated Cerebral Blood Flow Monitoring
Investigator
Changhuei Yang
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Optical monitoring of brain activities is intrinsically associated with a range of operational advantages:
a. non-ionizing and safe radiation, b. simple and relatively lightweight apparatus, c. readily available
commercial optical advanced systems that can be cross adapted for our usage.
TitleInterrogating the propagation of electrical stimulation across scales in vivo
Investigator
Daniel James Denman
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Intracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in
several animal model systems. However, little is actually known about the ensembles of neurons activated by
typical and clinical intracranial EBS protocols.
TitleIntersectional transgenic targeting of discrete neuronal and glial subtypes
Investigator
Jeffrey Mumm
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Tools for exclusively targeting neuronal and glial subtypes are needed to advance our understanding of the brain.
“Intersectional” systems improve targeting by restricting “reporter/effector” transgenes to a subdomain defined
by the expression overlap between two activating factors.
TitleInvestigating Functional Ependymal Cell Heterogeneity in the Ventricular System
Investigator
Stephanie Redmond
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract:
Glial cells collectively outnumber neurons in the vertebrate brain, but mechanistic understanding of their
molecular subtypes and functions is lacking.
TitleiSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains
Investigator
Hong Chen, Ilya E. Monosov
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Critical advances in the treatment of human brain disorders are hindered by our inability to specifically target
dysfunctional circuitry in a safe and noninvasive manner.
TitleLong-range neuronal projections: circuit blueprint or stochastic targeting? Rigorous classification of brain-wide axonal reconstructions
Investigator
Giorgio A Ascoli
Institute
george mason university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT (PROJECT SUMMARY)
The classification of neurons in the mammalian brain has long been a focus of intensive investigation in
neuroscience.
TitleMap Manager: Longitudinal image analysis with online editing and sharing.
Investigator
Robert Harry Cudmore
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
The increasing availability and ease of use of confocal, two-photon, and light-sheet microscopes coupled with
rapid developments in fluorescent protein reporters have made 3D and functional imaging and its analysis a
central component of modern Neuroscience research.
TitleMapping Algorithmic State Space in the Human Brain
Investigator
Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this
cognitive flexibility is our ability to respond correctly to novel contextual situations on the first attempt, without
prior rehearsal.
TitleMapping thalamo-striatal neuronal circuits underlying motivational drive
Investigator
Sofia Beas
Institute
national institute of mental health
Fiscal Year
Funding Opportunities Number
Project Number
Motivational drive is an adaptive process that helps individuals overcome obstacles to obtain essential needs and hence ensure survival. Motivation is composed of two major components.
TitleMechanisms of basal forebrain control over sensory processing
Investigator
Elizabeth Hanson Moss
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A key problem in neuroscience is understanding how internal and external information are integrated in the brain to produce
sensory experiences, cognition, and behavioral responses.
TitleMinimally Invasive Ultrasonic Brain-Machine Interface
Investigator
Richard A Andersen, Mikhail Shapiro, Mickael Tanter
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Brain-machine interfaces (BMIs) are one of the key motivating applications for the BRAIN Initiative’s drive to develop
innovative technologies for large-scale recording of neural activity, benefiting not only BMI, but many other neuroscience
studies.
TitleMolecular identity, cellular physiology, and in vivo functions of nucleus accumbens astrocytes
Investigator
Kay Elizabeth Linker
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Astrocytes are pervasive throughout the CNS and are the most abundant non-neuronal cell type. They
are an essential component of neural circuits, and increasing evidence demonstrates they are specialized for
specific brain regions.
TitleMolecular recording to predict cell fate decisions and animal behavior
Investigator
Joseph D Dougherty, Robi D Mitra
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The brain is remarkably complex, and our understanding of this organ is still in its infancy. Many
fundamental questions about brain development and function remain.