Funded Awards

The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.

To see more NIH-funded awards and associated publications, please visit the NIH RePORTER. 

Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitlemRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes
Investigator
Melissa Mckenzie Campbell
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
RFA-NS-19-043
Project Number
1K99MH126430-01
Project Summary/Abstract Alternative splicing of pre-mRNAs is extensively employed by the nervous system to expand the transcriptomic manifold.
TitleMulti-color optical voltage imaging of neural activity in behaving animals
Investigator
Mark J Schnitzer, Ganesh Vasan
Institute
stanford university
Fiscal Year
Funding Opportunities Number
RFA-NS-18-019
Project Number
1U01NS120822-01
Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures.
TitleMultimodal probes for multiscale calcium imaging
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
RFA-EY-18-001
Project Number
1R21EY032369-01
A major goal of the BRAIN Initiative is to promote the development of neural activity measurement tools that bridge between spatial scales, so that the processing roles of individual neurons and microcircuits can be related to broader regional or brain-wide dynamics.
TitleMultiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution
Investigator
Lin Tian, Mark E Vonzastrow
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
RFA-NS-18-019
Project Number
1U01NS120820-01
Project Summary The dynamic adaptability of the mammalian brain to environmental changes is remarkable, as it is the complexity of the networks of neurons underlying the operations that allow for such adaptations.
TitleNABOR: A Sustainable, High-quality Neuroscience Antibody Open Resource
Investigator
Melina Fan
Institute
addgene, inc.
Fiscal Year
Funding Opportunities Number
RFA-NS-19-006
Project Number
1U24NS119916-01
PROJECT SUMMARY The goal of this project is to build an open-access recombinant antibody/affinity reagent resource for the neuroscience community called NABOR (Neuroscience AntiBody Open Resource).
TitleNanosensors for sensitive brain-wide neurochemical imaging
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
RFA-NS-18-020
Project Number
1R01NS120592-01
The large-scale dynamics of neural circuitry depend on interactions among numerous neurochemical spe- cies that play functionally distinct roles throughout the brain.
TitleNational Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
Investigator
Mark H Ellisman
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
RFA-NS-19-006
Project Number
1U24NS120055-01
PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN Initiative.
TitleNeural dynamics of somatosensory guidance of dexterous movement in intact and stroke-injured networks
Investigator
Preeya Khanna
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
RFA-NS-19-043
Project Number
1K99NS124748-01
PROJECT SUMMARY Stroke-causing illness, disability, and early death is set to double worldwide within the next 15 years.
TitleNeural mechanisms of multisensory auditory-olfactory integration in the auditory cortex
Investigator
Nathan Vogler
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
RFA-MH-20-620
Project Number
1F32MH127788-01
PROJECT SUMMARY Living organisms interact with complex environments that are inherently multisensory. Within these environments, the brain must integrate information from multiple sensory modalities, including the auditory and olfactory systems, for perception and behavior.
TitleNeural Mechanisms of Transcranial Current Stimulation
Investigator
Bart Krekelberg, Pierre- Olivier Polack
Institute
rutgers the state univ of nj newark
Fiscal Year
Funding Opportunities Number
RFA-NS-20-006
Project Number
1R01NS120289-01A1
Project Summary Transcranial current stimulation (TCS) creates small electrical fields in the brain through electrodes placed on the scalp.
TitleNeuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural Interfaces
Investigator
Hui Fang, Jonathan Viventi
Institute
duke university
Fiscal Year
Funding Opportunities Number
RFA-NS-18-019
Project Number
1U01NS123668-01
Project Summary / Abstract The purpose of this project is to optimize circuit and system architectures of active electrode arrays which will provide low-noise, multiplexed acquisition of neural signals from thousands of electrodes.
TitleNeuroExM
Investigator
Jacob R Glaser
Institute
microbrightfield, llc
Fiscal Year
Funding Opportunities Number
PA-18-871
Project Number
1R42MH124566-01A1
Abstract This project describes the development of NeuroExM™, a highly innovative system for performing comprehensive spatial distribution analysis of populations of messenger RNAs (mRNAs) and proteins in tissue processed for expansion microscopy (ExM)).
TitleNeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform
Investigator
Qianqian Fang
Institute
northeastern university
Fiscal Year
Funding Opportunities Number
RFA-NS-19-006
Project Number
1U24NS124027-01
Traditional file-based neuroimaging data management and integration strategies have shown increasing limitations in accommodating the meteoric growth in both the scale and complexity of today’s neuroimaging data.
TitleNIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species
Investigator
Oscar Esteban, Michael Peter Milham, Russell A Poldrack, Ariel Shalom Rokem, Theodore Satterthwaite
Institute
stanford university
Fiscal Year
Funding Opportunities Number
RFA-MH-19-147
Project Number
1RF1MH121867-01A1
Project Summary Despite the rapid advances in the neuroimaging research workflow over the last decade, the enormous variability between and within data types and specimens impedes integrated analyses.
TitleNovel high-field MRI compatible subdural electrode and acquisition system for recording and stimulation in small animals
Investigator
Hernan Millan
Institute
emri systems llp
Fiscal Year
Funding Opportunities Number
PA-18-870
Project Number
1R43MH128138-01
Abstract Preclinical small animal imaging makes valuable contributions to improving our understanding of human brain.
TitleOpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function
Investigator
Christof Koch, Jerome Anthony-Jean Lecoq
Institute
allen institute
Fiscal Year
Funding Opportunities Number
RFA-NS-19-006
Project Number
1U24NS113646-01A1
Project summary Over the past five years, the Allen Institute has built two unique in-house pipelines for in vivo electro- and optical-physiology: together they form the Allen Brain Observatory.
TitleOptical gearbox for high speed neural recording
Investigator
Meng Cui, Guang Yang
Institute
purdue university
Fiscal Year
Funding Opportunities Number
RFA-EY-18-001
Project Number
1R21EY032382-01
The rapid advance of genetically encoded functional indicators allows the scientists to visualize neuronal activities with light in the living brain at high spatiotemporal resolutions.
TitleOptimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice
Investigator
Robert E. Campbell, Hod Michael Dana, Marie-Eve Paquet
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
RFA-NS-18-019
Project Number
1U01NS123658-01
Project Summary The goal of this proposed research is to optimize a dual-use calcium ion sensor for recording single-cell activity from the entire dorsal cortex or hippocampus of freely-moving mice.
TitleOptimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulation
Investigator
Samuel Andrew Hires, Yulong Li
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
RFA-NS-18-019
Project Number
1U01NS120824-01
Neuromodulators regulate addiction, attention, cognition, mood, memory, motivation, sleep, and more through their influence on brain circuits. Classic tools for measuring neuromodulation in the brain have poor spatial and temporal resolution.
TitleQuantitative Diffuse Correlation Spectroscopy for Assessing Human Brain Function
Investigator
Ulas Sunar
Institute
wright state university
Fiscal Year
Funding Opportunities Number
RFA-EB-20-001
Project Number
1R01EB031759-01
PROJECT SUMMARY/ABSTRACT Acute brain injuries can lead to secondary brain damage that worsens the outcome. Reduced cerebral blood flow can induce ischemia, while excess blood flow can cause hemorrhage.
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