ABSTRACT
Optical imaging holds tremendous promise in our endeavor to understand brain functions. The major challenges
for optical brain imaging are depth and speed.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleReal-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain
Investigator
Steven Graham Adie
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
TitleRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning
Investigator
Peter V. Kochunov, Paul M Thompson
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-
related patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing
Neuroimaging Genetics through Meta-Analysis (ENIGMA).
TitleResolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods
Investigator
Genevieve Lauren Stein-O'brien
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
High-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently
underway.
TitleRobotically-actuated, low-noise, concurrent TMS-EEG-fMRI system
Investigator
Chunlei Liu, Michael Lustig, Angel V Peterchev
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The ability to noninvasively modulate and image the brain with spatial and temporal precision is highly desirable
for understanding brain circuits in health and disease.
TitleScalable tools for consistent identification of neuronal cell types in mouse and human
Investigator
Staci A Sorensen, Uygar Sumbul
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by
developing machine learning algorithms and cloud-based software for the integration of multiple modality
characterizations large and growing datasets of cortical neurons in mou
TitleSecondary analysis of functional MRI and resting state connectivity in white matter
Investigator
John C Gore, Bennett A. Landman
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Abstract / Summary
This proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI
studies in order to quantify the functional characteristics of white matter (WM) and their changes during
normal aging and in the progression to Alzheimer’s Disease (AD).
TitleSelective Control of Synaptically-Connected Circuit Elements by Interluminescence
Investigator
Ute H Hochgeschwender, Christopher I Moore
Institute
central michigan university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A wealth of new tools can directly control output of specific neurons on fast (e.g., optogenetic) or sustained (e.g.,
chemogenetic) time scales.
TitleSensiTrak: Automated Assessment of Forelimb Sensation
Investigator
Andrew Michael Sloan
Institute
vulintus, llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
In this Phase I STTR project, Vulintus, Inc., in collaboration with Columbia University, proposes
to develop and test ‘SensiTrak,’ an automated, high-throughput behavioral system designed to
finely measure somatosensory function in rodent models.
TitleSensory motor transformations in human cortex
Investigator
Richard A Andersen
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: The long-term objective of this application is to understand cortical processing of sensory to
motor transformations within the human cerebral cortex. A vast number of computations must be
performed to achieve sensory-guided motor control.
TitleSex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
Investigator
Brandy A. Briones
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits.
TitleSimultaneous functional MRI and Micro-Magnetic Nervous System Stimulation
Investigator
Ilknur Ay, Giorgio Bonmassar, Xin Yu
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Micromagnetic stimulation (µMS) has several advantages over electrical stimulation. First, µMS does not
require charge-balanced stimulation waveforms as in electrical stimulation. In µMS, neither sinks nor sources
are present when the time-varying magnetic field induces a current.
TitleSimultaneous, Cell-Resolved, Bioluminescent Recording From Microcircuits
Investigator
Nozomi Nishimura, Chris B Schaffer
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Measuring the activity of many individual neurons at once while knowing their wiring diagrams would provide
exciting information on how the components of a network interact.
TitleSmall molecule regulation of endogenous transcription factors for circuit-specific neuromodulation
Investigator
Gerald R. Crabtree
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Methods for regulating cellular processes within distinct populations of neurons are needed to elucidate
relationships between molecular mechanisms, circuits, and behavior; and to develop cell type- or circuit-
selective treatments for neurological disorders.
TitleStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
Investigator
Daniel Lu
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Respiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure
is the leading cause of death in patients with SCI.
TitleStructure and function of spontaneous network activity during circuit formation
Investigator
Arnaldo Carreira-Rosario
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations
during this time can cause lifelong circuit and behavioral changes.
TitleSWITCH trial: Early feasibility study of Stentrode BCI for augmentative communication
Investigator
Nicholas Lachlan Opie, Thomas J Oxley, David Francis Putrino, Douglas J Weber
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary
Multiple early feasibility trials in humans have demonstrated that implantable Brain-Computer Interfaces (BCIs) can enable
people with severe paralysis to use neural signals to control remote and digital communication technologies, including
messaging and email.
TitleThalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome
Investigator
Martha J Morrell
Institute
neuropace, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive
dysfunction and very frequent generalized onset seizures (GOS) often leading to injury.
TitleThe first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases
Investigator
Oliver Graudejus
Institute
bmseed, llc
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The proposed work aims at the development of an enhanced organoid-based in vitro pre-clinical drug
screening platform for neurological and neurodegenerative brain diseases.
TitleThe power of positivity: a novel class of voltage indicators for high-fidelity brain activity imaging
Investigator
Michael Z. Lin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
To understand how the brain functions in health, and how sensory, motor, and cognitive functions are affected in disease, it
is crucial to be able to record the activities of large numbers of individual neurons in real time.
TitleThe representation and modulation of sensory information in the learning and memory center of the Drosophila brain
Investigator
Andrew M Davidson
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses the combined physiology of many cells to transform incoming sensory signals into internal
representations.