Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in
neural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish
an independent nonhuman primate (NHP) laboratory with two primary aims.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCharacterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces
Investigator
Karen Elizabeth Schroeder
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
TitleCircuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.
Investigator
Brandon J Mark
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise
control of large numbers of motor neurons.
TitleCloud-based Software Framework to Simplify and Standardize Real-Time fMRI
Investigator
Jonathan D Cohen, Kenneth A Norman
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: (30 lines of text max)
We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback
experiments.
TitleCombined Topological and Machine Learning Tools for Neuroscience
Investigator
Michael Hawrylycz, Partha Pratim Mitra, Yusu Wang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Two major recent advances have raised the possibility of fundamental breakthroughs in both
basic and clinical neuroscience: the development of new tools to probe the nervous system with
single-cell resolution as well as brain-wide scope, and breakthroughs in machine learning
methods for handling com
TitleContext-dependent neural processing of leg proprioception in Drosophila
Investigator
Sweta Agrawal
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Proprioception is critical for effective motor control: dysfunctions of the proprioceptive system can impair
balance, motor coordination, and motor learning.
TitleCortical-Basal Ganglia Speech Networks
Investigator
Robert Mark Richardson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-
thalamocortical loops. Speech is one example, although how the basal ganglia participate in this uniquely
human behavior is not clear, due to a lack of empirical data.
TitleCoupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis
Investigator
Daniel Maxim Iascone
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Circadian rhythms are necessary to coordinate the timing of key behavioral and physiological processes in
mammals [1-3].
TitleCritical Technology Development for 16 Tesla Head-only MRI Superconducting Persistent Magnets: V2
Investigator
Minfeng Xu
Institute
general electric global research ctr
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Advanced brain research demands ultra-high field MRI systems. The 11.7 T Neurospin CEA MRI magnet
pushed the use of superconducting NbTi materials to the limit by using superfluid helium to cool.
TitleCross-frequency coupling: its role in brain function and dysfunction
Investigator
Andrei V Medvedev
Institute
georgetown university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
One of the high priority research areas listed in the BRAIN 2025 Report is a better understanding of the
brain network dynamics across time and space from human electrophysiological recordings.
TitleData Exploration and Analysis Portal for Brain Research through Advanced Imaging Neuroscience
Investigator
Chun Chieh Fan, Wesley Kurt Thompson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Population neuroscience requires investigation of brain-behavioral relationships within epidemiological
samples studied in longitudinal designs, including a large number of assessment modalities and with subjects
enrolled at many data collection sites to achieve a large sample and br
TitleDataJoint Pipelines for Neurophysiology
Investigator
Dimitri Yatsenko
Institute
vathes inc.
Fiscal Year
Funding Opportunities Number
Project Number
The field of neuroscience and the BRAIN Initiative in particular are amassing a wealth of informatics resources for managing, analyzing, and sharing data.
TitleDecision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.
TitleDefining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
TitleDeveloping a novel therapeutic for treating tinnitus
Investigator
Luisa L Scott
Institute
cognosetta, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Tinnitus or “ringing in the ears” is a hearing disorder that disproportionately impacts those who are or have served
in the military. There is currently no effective cure for tinnitus.
TitleDeveloping Molecular and Computational Tools to Enable Visualization of Synaptic Plasticity In Vivo
Investigator
Richard L Huganir
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Developing new methodological and analytical tools to address currently insurmountable experimental questions
is crucial to the future of neuroscience.
TitleDevelopment of multi-color, bright chemigenetic indicators to image synaptic transmission
Investigator
Lin Tian
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Activity of the brain across structures is an orchestrated process that spans a broad range of time
and space scales. Highly coordinated communication is what activate responses to stimuli, makes
behavior possible, and generates memories.
TitleDevelopment of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
TitleDissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
TitleDissemination of 3-photon imaging for chronic cellular imaging across species
Investigator
Jack Waters
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Activity-sensitive fluorescent indicators and microscopy have proven valuable tools for measuring neuronal
activity, but most forms of cellular microscopy can produce images of neurons only near the brain surface and
generally only after removal of tissues overlying the brain surface, such
TitleDopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.