Project Summary
Integration of sensory information with motor commands allows movement to be adaptable. For example,
many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement
trajectories based on interaction with objects (e.g.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleProprioceptive Coding of Jaw Movement during Orofacial Behavior
Investigator
William Paul Olson
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
TitleRapid and Agile Multi-Photon Optical Imaging Over Large Neural Volumes
Investigator
Mark A Foster
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/ Abstract
Multi-photon, depth-sectioning microscopes are of paramount importance in capturing neural activity with cellular
resolution.
TitleRapid Evaluation of Neuronal Activity in the Intact Whole-Brain at Single Cell Resolution
Investigator
Damian G. Wheeler
Institute
translucence biosystems, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
New imaging tools are needed for brain-wide visualization of the neural activity underlying defined
behaviors. Live imaging techniques such as fMRI and MEG measure activity across the brain, but
these methods cannot resolve single cell activity.
TitleRapid, single-cell level molecular phenotyping of intact brains via active immunohistochemistry
Investigator
Adam C Hall, Frank He, Jeffrey Stirman
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract. Cell-level analysis and a growing appreciation of cell-type diversity have transformed our
understanding of the brain.
TitleRe-engineering Rabies Virus
Investigator
Ian R Wickersham
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Every part of the brain is composed of dense tangles of heavily-interconnected neurons of many different types,
each playing completely different roles in the circuitry.
TitleRelating functional MRI to neuronal activity: accounting for effects of microarchitecture
Investigator
Anna I Blazejewska
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits.
TitleResponsive Neurostimulation for Loss of Control Eating
Investigator
Casey Harrison Halpern, James D Lock, Robert C Malenka, Tara L Skarpaas (Crowder)
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Background/Description.
TitleResponsive Neurostimulation for Post-Traumatic Stress Disorder
Investigator
Jean-Philippe Langevin
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Post-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its
biological substrate, amygdala reactivity to trauma reminders13,14.
TitleRevealing the transcriptional and developmental mechanisms of interneuron identity
Investigator
Megan Crow
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Cortical GABAergic interneurons are critical components of neural circuitry, and their dysfunction has been
linked to neurodevelopmental diseases.
TitleSelf-Image-Guided Flexible Ultrasonic Interrogation Platform for Neural Dust
Investigator
Mehdi Kiani
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Dynamic mapping of complex brain circuits by monitoring and modulating brain activity at a large scale will
enhance our understanding of brain functions, such as sensation, thought, emotion, and action.
TitleSingle Neuron Analyzer for Multi-modal, Cross-dataset (Epi)genomic Cell Type Datasets
Investigator
Eran A Mukamel
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Our project will create a computational resource, the Single Neuron Analyzer, to support the neuroscience
community’s efforts to build a reproducible, comprehensive, data-driven atlas of brain cell types.
TitleSpinal Effects of Cortical Stimulation: Mechanisms and Functional Impact
Investigator
Jonathan Saul Carp, Yu Wang, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Because activity-dependent plasticity is ubiquitous in the CNS, brain stimulation may have long-term effects on
areas to which the stimulated area connects. These effects have received little attention.
TitleSubcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During Behavior
Investigator
Mai-Anh Vu
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The basal ganglia are a group of deep brain nuclei that play a central role in motivating, selecting, and learning
actions.
TitleTechnology development for closed-loop deep brain stimulation to treat refractory neuropathic pain
Investigator
Edward Chang, Philip Andrew Starr
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Many pain syndromes are notoriously refractory to almost all treatment and pose significant costs to patients
and society. Deep brain stimulation (DBS) for refractory pain disorders showed early promise but
demonstration of long-term efficacy is lacking.
TitleThalamic stimulation to prevent impaired consciousness in epilepsy
Investigator
Hal Blumenfeld
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Impaired consciousness during seizures has a major negative impact on quality of life for people with epilepsy.
Consequences include risk of motor vehicle accidents, drowning, poor work and school performance, and
social stigmatization.
TitleThe glial mechanism for electrical brain stimulation
Investigator
Hai-Long Wang, Gregory A Worrell, Long-Jun Wu
Institute
mayo clinic rochester
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT:
Electrical brain stimulation (EBS) is a FDA-approved neuromodulation therapy applied to several
neurological disorders. However, the molecular basis of its efficacy remains unclear.
TitleThe Neural Mechanism of Interval Timing in Drosophila
Investigator
Ashley Danielle Smart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is no dedicated sensory organ for time, and yet our brains are able to use time to anticipate the
environment and adapt.
TitleThe Neuroimaging Data Model: FAIR descriptors of Brain Initiative Imaging Experiments
Investigator
David Bryant Keator
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Reuse of existing neuroscience data relies, in part, on our ability to understand the experimental design and
study data.
TitleTime-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain
Investigator
Maria Angela Franceschini
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Functional near-infrared spectroscopy (fNIRS) is a well-established neuroimaging method which enables
neuroscientists to study brain activity by non-invasively monitoring hemodynamic changes in the cerebral cortex.
In the last decade, the use of fNIRS has increased significa
TitleTransparent neural interface for in vivo interrogation of human organoids
Investigator
Anna Devor
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Recent advances in pluripotent stem cell technology have enabled generation of neuronal cell lines and
cerebral organoids from human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells
(hiPSCs) derived from peripheral tissues.