PROJECT SUMMARY
The wealth, depth and quality of multi-omic data generated through funding from the BRAIN
initiative is unprecedented. It ranges from bulk and single cell RNA-seq, to detailed cell type-
specific epigenetic analyses throughout development.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleIlluminating Neurodevelopment through Integrated Analysis and Vizualization of Multi-Omic Data
Investigator
Ronna Hertzano, Owen R White
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
TitleImaging the D2/A2A Heterodimer with PET
Investigator
Robert H Mach
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of this research project is to determine if it is possible to develop a PET radiotracer capable of
imaging GPCR heterodimers and not their corresponding homodimeric complexes.
TitleIn Vivo Brain Network Latency Connectome Mapping
Investigator
Peter Basser
Institute
national institute of biomedical imaging and bioengineering
Fiscal Year
Funding Opportunities Number
Project Number
We are pleased with the progress we are making in this "team building" R24 grant which our group received through the NIH BRAIN Initiative. We have been informed that ours is the only group within the NIH IRP to have received such an award.
TitleIn Vivo Imaging of Local Synaptic Neuromodulation by Dopamine
Investigator
Paul Robert Evans
Institute
max planck florida corporation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Dopamine (DA) is a powerful neuromodulator that facilitates memory formation and underlies reward-related
behaviors by regulating synaptic plasticity.
TitleIncreased thalamocortical connectivity in tdcs-potentiated generalization of cognitive training
Investigator
Kelvin O. Lim, Angus W Macdonald
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive neuromodulation, such as transcranial direct current stimulation (tDCS), is emerging as an
important therapeutic tool with documented effects on brain circuitry, yet little is understood about how it
changes cognition.
TitleInforming Choice for Neurotechnological Innovation in Pediatric Epilepsy Surgery
Investigator
Judy Illes, Patrick Mcdonald
Institute
university of british columbia
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
More than 500,000 children in the USA and Canada suffer from epilepsy today. Unmanaged, epilepsy can
result in cognitive decline, social isolation and poor quality of life, and has substantial economic impact on
families and society.
TitleIntracellular calcium sensing with molecular fMRI
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
The development of minimally invasive direct readouts of neural activity is one of the greatest challenges
facing neuroscience today.
TitleInvestigating the hypocretin to VTA circuit in memory consolidation during sleep
Investigator
Jeremy Borniger
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Chronic sleep disturbance affects 10-20% of the population in the developed world, representing a substantial public
health problem. Given the ubiquitous nature of sleep across the animal kingdom, intense investigation is underway into
the biological functions of sleep.
TitleIs the Treatment Perceived to be Worse than the Disease?: Ethical Concerns and Attitudes towards Psychiatric Electroceutical Interventions
Investigator
Laura Yenisa Cabrera Trujillo
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
7. PROJECT SUMMARY/ABSTRACT
Mental health disorders cause immense personal suffering and represent a significant societal burden.
TitlekHz-rate in vivo imaging of neural activity througout the living brain
Investigator
Na Ji, Kevin Kin Man Tsia
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
TITLE
kHz-rate in vivo imaging of neural activity throughout the living brain
SUMMARY
The overarching challenge in neuroscience today is how to monitor the neural signaling events in intact
brains of behaving animals at synaptic or cellular spatial resolution and millisecond time resolution.
Multiph
TitleLarge-scale cellular-resolution voltage imaging of the zebrafish brain
Investigator
Yiyang Gong
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Recording the spiking activity of many individual neurons in a densely packed region of the brain
has been a standing challenge for the neuroscience community.
TitleLightweight, Compact, Low-Cryogen, Head-Only 7T MRI for High Spatial Resolution Brain Imaging
Investigator
Thomas Foo, Yunhong Shu, Duan Xu
Institute
general electric global research ctr
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
An innovative head-only 7T MRI system that delivers spatial resolution that is difficult to achieve with today's
whole-body 7T systems, and has the footprint and weight of a whole-body 3T scanner is proposed.
TitleLinking neuronal, metabolic, and hemodynamic responses across scales
Investigator
Geoffrey M Ghose
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
While functional magnetic resonance (fMRI) has proved invaluable for identifying where in the
brain activation is occurring during a particular task, it has had less to say about how the
dynamics of that activation actually contribute to task performance.
TitleMagnetic camera based on optical magnetometer for neuroscience research
Investigator
Orang Alem
Institute
fieldline, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
During Phase I, we will test the feasibility of developing a magnetographic camera technology as a new tool in
neuroscience to facilitate the detailed analysis of electrical currents in diverse neuronal circuits.
TitleMechanisms of electrical stimulation of a canonical motor microcircuit
Investigator
Charles Heckman
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
The neural circuitry of the spinal cord has a unique, repetitive structure that forms an especially promising
target for control via electrical stimulation.
TitleMechanisms of Rapid, Flexible Cognitive Control in Human Prefrontal Cortex
Investigator
Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of
this cognitive flexibility is our ability to perform complex, yet previously un-practiced tasks successfully on
the first attempt.
TitleMechanisms underlying positive and negative BOLD in the striatum
Investigator
Yen-Yu Ian Shih
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) is widely used
as a non-invasive technique to study brain function.
TitleMechanistic and causal basis of fMRI functional connectivity in non-human primates
Investigator
Peter Rudebeck, Brian E Russ
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Measures of functional magnetic resonance imaging (fMRI) functional connectivity – correlated blood oxygen
level dependent (BOLD) responses – are fundamental to understanding the circuit-level mechanisms of brain
function and dysfunction.
TitleMemory consolidation during sleep studied by direct neuronal recording and stimulation inside human brain
Investigator
Itzhak Fried
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Memory is critical for cognitive well-being, and sleep is critical for memory consolidation, yet the underlying
mechanisms in the human brain are poorly understood.
TitleMINIMALLY-INVASIVE NANO-DIALYSIS NEURAL PROBE FOR MULTIPLEXED MONITORING OF NEUROCHEMICALS WITH HIGH SPATIO-TEMPORAL RESOLUTION
Investigator
Rashid Bashir, Jonathan V. Sweedler, Yurii A Vlasov
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Monitoring local concentrations of neurochemicals in specific parts of the brain in vivo is critical for correlating
neural circuit functionality to behavior as long-range neuromodulation can significantly alter information
processing.