PROJECT SUMMARY ABSTRACT
The lateral cerebellum (Crus I/II) interacts with two dissociable large-scale brain networks — the executive
control (ECN) and default mode networks (DMN), which support distinct cognitive functions (e.g., prediction
versus episodic memory, respectively).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleOptimizing noninvasive modulation of prediction and episodic memory networks via cerebellar stimulation
Investigator
Shruti Dave
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
TitlePARALLEL ANALYSIS OF TRANSCRIPTION AND PROTEIN-DNA INTERACTIONS IN SINGLE CNS CELLS
Investigator
Joseph D Dougherty, Robi D Mitra
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The brain is the most complex organ in the body, consisting of hundreds of molecularly, physiologically, and
anatomically distinct cells.
TitlePopulation Imaging of Action Potentials by Novel Two-Photon Microscopes and Genetically Encoded Voltage Indicators
Investigator
Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how information is processed in the mammalian neocortex has been a longstanding question in
neuroscience. While the action potential is the fundamental bit of information, how these spikes encode
representations and drive behavior remains unclear.
TitlePrototyping an ultrasound system for spatiotemporally precise noninvasive neuromodulatory drug uncaging and functional imaging in awake primates
Investigator
Charles F Caskey
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Currently, no technology exists that has been specifically designed to allow high precision noninvasive
neuromodulation and neuroimaging in awake animals. Ultrasound is an ideal modality to fill this void since it has
been used (1) directly for neuromodulation,
TitleQuantifying the role of adaptation in olfactory coding through the logic of navigation
Investigator
Nirag Kadakia
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This project’s long-term goal is a fuller understanding of the neurobiological mechanisms of olfactory sensory
adaptation that facilitate odor discrimination in the natural world.
TitleQuantitative mapping of oxygenation around neural interfaces using novel PISTOL MR imaging
Investigator
Vikram D. Kodibagkar, Jitendran Muthuswamy, Arati Sridharan
Institute
arizona state university-tempe campus
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Oxygen levels (pO2) in the brain play a significant role in influencing the function of single neurons and
neuronal networks during normal and pathological states.
TitleRapid 3-D Nano-Printing to Create Multi-Thousand-Channel Microelectrode Arrays
Investigator
Rahul Panat, Eric Yttri
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Recent advances in technology have enabled the sampling of activity from up to a few hundred neurons within
a limited area of the brain.
TitleRAVE: A New Open Software Tool for Analysis and Visualization of Electrocorticography Data
Investigator
Michael S Beauchamp
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique
that allows the activity of small population of neurons in the human brain to be directly recorded.
TitleRecombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Investigator
James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Understanding brain function and dysfunction requires an understanding of the circuitry of the brain from
molecules to cells to circuits.
TitleRemote Neurostimulation with Ultrasound-activated Piezoelectric Nanoparticles
Investigator
Geoffrey P. Luke
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The ability to trigger neural activity with high resolution millimeters to centimeters deep in tissue remains an
elusive goal in neuroscience research. Current research relies on using invasive electrodes, optogenetics, or
pharmacological stimulation.
TitleRepetitive transcranial ultrasound stimulation for modulating brain rhythms
Investigator
Jacek Dmochowski
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of the proposed research career development program is to allow the applicant to acquire training in
a new form of brain stimulation using ultrasonic waves.
TitleResource for Multiphoton Characterization of Genetically-Encoded Probes
Investigator
Mikhail Drobizhev
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
Two-photon laser scanning microscopy powers many projects in the.
TitleSCAPE microscopy for high-speed 3D imaging of cellular function in behaving animals: Continued innovation, optimization, and dissemination
Investigator
Elizabeth M. C. Hillman
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Swept confocally aligned planar excitation (SCAPE) microscopy is a method for high-speed, cellular level
imaging of living, intact tissues.
TitleSelective Optogenetic Inhibition of Neuropeptide Release
Investigator
Pablo Blinder, Zhitao Hu, John Yu-Luen Lin
Institute
tel aviv university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Neuropeptides are key components of modulation across the central nervous system.
TitleSpatially Resolved Methylomes to Map Neuronal Cell-Type Connectivity in Tissue
Investigator
Robert Youssefian Henley
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The BRAIN initiative has put forth the development of a neuronal cell-type census as the first step towards
mapping the structure and components of neuronal circuits.
TitleSynthetic imager to record cortical neural activity over whole cranium in freely-behaving animals
Investigator
Weijian Yang
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Synthetic imager to record cortical neural activity over whole cranium in freely-behaving animals
Understanding information flow across different brain regions during animal behavior is a key step to
decipher how the brain works.
TitleTaking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo
Investigator
Nicole Calakos
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The basal ganglia are critical for the learning and subsequent selection of motor programs. In health,
adaptive plasticity in the basal ganglia enables easy execution of complex motor tasks through
formation of habits.
TitleTechnology for functional study of cells and circuits in large postmortem brains ex vivo
Investigator
Nenad Sestan
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The mammalian brain is arguably the most complex biological structure.
TitleThe biophysics and potential cell-type selectivity of acoustic neuromodulation
Investigator
Robert Crooks Froemke, Eitan Kimmel, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Neuroscience has an essential requirement for large-scale perturbation tools. Such
tools would be transformative in the mapping of brain function, the causal testing of
neurotheoretic models, and the diagnosis and treatment of neurological disorders.
TitleThe Brainstorm Project: A Collaborative Approach to Facilitating the Neuroethics of Bioengineered Brain Modeling Research
Investigator
Insoo Hyun
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary – Abstract
Neuroscientists are getting close to building realistic bioengineered ex vivo human brain models
by: (1) introducing perfusable vascular networks to maintain tissue viability and promote 3D
brain model growth; (2) generating the full complement of currently missing cell ty