Abstract
This project will develop a novel infrared-based neuro-stimulation tool for specifically modulating neural
circuitry. Transcranial infrared brain stimulation (TIBS) at 1064 nm will be developed as a new tool for non-
invasive neuromodulation of the human brain.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNovel Neuromodulation by Transcranial Infrared Brain Stimulation with Imaging
Investigator
Francisco Gonzalez-Lima, Hanli Liu
Institute
university of texas arlington
Fiscal Year
Funding Opportunities Number
Project Number
TitleOptimization of multiphoton microscopy for large scale activity mapping in adult zebrafish
Investigator
Joseph R. Fetcho, Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Vertebrate behaviors emerge from interactions of neurons across the brain, but the tools for revealing
neuronal structure and function at the cellular level in living animals access only small portions of the brain.
TitleProsthetic System for Large-Scale Recording and Manipulation of Neural Circuit Activity in Non-Human Primates
Investigator
Albert Baldwin Goodell
Institute
graymatter research
Fiscal Year
Funding Opportunities Number
Project Number
The fundamental objective of the BRAIN Initiative is to understand how dynamic activity in distributed
neural circuits mediates human cognitive behavior.
TitleResolving Fine Architectures of Human Gray Matter with Ultra-High-Resolution Diffusion MRI
Investigator
Yulin Ge, Jiangyang Zhang
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our brain is a complex network with multiple levels of organization in white matter (WM) and gray
matter (GM). The axonal and dendritic organizations of local GM tissue form one of the structural bases of
normal brain functions.
TitleRevealing circuit control of neuronal excitation with next-generation voltage indicators
Investigator
Thomas Robert Clandinin, Michael Z. Lin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Recording the electrical impulses of individual neurons in intact brain circuits in real time has been a longstanding goal in
neuroscience.
TitleReversing Synchronized Brain Circuits with Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts
Investigator
Susan E Shore
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The dorsal cochlear nucleus (DCN) integrates auditory and somatosensory information through circuitry that
modulates activity of the principal output neurons of the circuit, the fusiform cells.
TitleSABER: Scalable Analytics for Brain Exploration Research using X-Ray Microtomography and Electron Microscopy
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Advances in imaging have had a profound effect on our ability to generate high-resolution measurements of
the brain’s structure.
TitleScalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials
Investigator
Dennis Alan Turner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
DBS therapy for Parkinson's disease is now the primary surgical approach for Parkinson's disease, recently
FDA approved at 4 years after onset of disease.
TitleSELF-POWERED SENSING AND DATA-LOGGING FOR LARGE-SCALE IN-VIVO MONITORING OF NEURAL ENSEMBLE ACTIVITY
Investigator
Shantanu Chakrabartty
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The current state-of-the-art neural recording technology is limited by the ability to remotely and continuously
deliver power to the implanted sensors.
TitleSpinal root stimulation for restoration of function in lower-limb amputees
Investigator
Lee E Fisher, Douglas J Weber
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Recent advances in design and actuation have led to important improvements in prosthetic limbs. However, these devices
lack a means for providing direct sensory feedback, requiring users to infer information about limb state from pressure on
the residual limb.
TitleSplit RNA polymerases for sensitive, multidimensional analysis of intercellular PPIs at synapses
Investigator
Bryan Dickinson, Engin Ozkan
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Deciphering the complex underpinning of brain structure and function requires a complete understanding of how
molecular contacts between cells in the brain are regulated.
TitleTechnologies to drastically boost photon sensitivity for brain-dedicated PET
Investigator
Craig S Levin
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
According to the BRAIN 2025 working group report, there is a need to drastically improve the spatiotemporal
resolution of positron emission tomography (PET), in order to facilitate the translation of new tracers that target
neuroreceptor function and dynamic PET imaging on t
TitleThe Application of Generalized Linear Models to Calcium Imaging Data for Optimal High-Dimensional Receptive Field Estimation and Identification of Latent Network Dynamics
Investigator
Stephen L Keeley
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
As new recording methods emerge in neuroscience, new statistical techniques are needed to properly relate
neural activity to behavior, a given stimulus, or an internal process.
TitleThe impact of cerebellar tDCS in local and downstream brain circuits: how much is neuralactivity modulated in the resting state and during sensorimotor processing?
Investigator
Javier F Medina
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Non-invasive stimulation of the cerebellum holds great promise for investigating brain function, and for
diagnosing and treating a variety of brain disorders.
TitleTrans-Sheet Illumination Microscopy (TranSIM) for decoding whole brain activity at submillisecond temporal resolution
Investigator
Katsushi Arisaka, Laurent A. Bentolila
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Today’s knowledge of large-scale neural networks is advancing along two orthogonal directions. Spatial (static, structural) connectomic understanding is achieved through optical and electron microscopy; yielding high spatial resolution with limited or no temporal information.
TitleTranscranial magnetic stimulation with enhanced focality and depth (fdTMS)
Investigator
Angel V Peterchev
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
This project will develop transcranial magnetic stimulation coils with improved focality and depth (fdTMS).
TMS is a technique for noninvasive brain stimulation using strong, brief magnetic pulses. TMS is widely used in
the neurosciences as a tool for probing brain function and connectivity.
TitleUnderstanding the synaptic, cellular and circuit events of MEG & EEG using a vertically translational cross-species approach
Investigator
Chengcheng Huang, Dean F Salisbury, Tobias Teichert
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
7. PROJECT SUMMARY
Background. Electro- and magneto-encephalographic (EEG/MEG) responses to a stimulus are systematically
attenuated– by up to 80%– if the same stimulus was presented less than 8-12 seconds ago.
TitleUsing fMRI to Measure the Neural-level Signals Underlying Population-level Responses
Investigator
Rosemary Alice Cowell, David Ernest Huber
Institute
university of massachusetts amherst
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The goal of this proposal is to advance our ability to accurately infer the properties of neu-
ral-level responses from the more coarse-grained information obtained with non-invasive imaging in humans.
To achieve this goal, the project will capitalize on feature-selective cortical r
TitleWide-field scan-less multi-photon endoscopy using spatio-temporal pulse delivery and temporal focusing
Investigator
Mark A Foster
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/ Abstract
Multiphoton, depth sectioning micro-endoscopes are of paramount importance in capturing neural activity with
cellular resolution.
TitleA high-speed volumetric multiphoton microscope for the study of developing neural circuits in retina
Investigator
Marla Feller
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Our research goal is to determine the factors that instruct the development of visual
responses in the mammalian retina. In particular, we are studying the developmental
period when the retina transitions from generating retinal waves to mediating visual
responses by forming functional circuits.