Neuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
PIs: Dr. John P. O'Doherty and Dr.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleNeuronal Substrates of Hemodynamic Signals in the Prefrontal Cortex
Investigator
Matthew A. Howard, John P O'doherty, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeurons, Vessels and Voxels: Multi-modal Imaging of Layer Specific Signals
Investigator
Prakash Kara, Thomas P Naselaris, Cheryl A. Olman, Kamil Ugurbil
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Our knowledge of signal processing in various parts of the human brain has been heavily influenced by non-
invasive functional magnetic resonance imaging (fMRI) experiments. FMRI infers the location and selectivity of
neural activity from vascular signals.
TitleNew approaches for better protein voltage sensors
Investigator
Lawrence B Cohen
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
This proposal aims to develop better tools for analyzing brain cells and circuits and for
large-scale recordings of brain activity. The currently available tools are relatively primitive in terms of sensitivity
and speed. One major function of a neuron is to process electrical signals.
TitleNext-gen Opto-GPCRs: spatiotemporal simulation of neuromodulator signaling
Investigator
Michael R Bruchas, Roger K Sunahara
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract: The emerging field of optogenetics — using light to engage biological systems
— holds tremendous promise for dissection of neural circuits, cellular signaling and manipulating
neurophysiological systems in awake, behaving animals.
TitleNon-invasive neuromodulation mechanisms and dose/response metrics
Investigator
Desmond Oathes
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
In an exciting era of growth in the use of non-invasive brain stimulation, new methods and applications are
being disseminated widely with an increasing number of FDA approvals and equipment designed to probe or
modulate the brain in fascinating new ways.
TitleNoninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's Disease
Investigator
Harrison Carroll Walker
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
It is easy to underestimate the importance of normal movement in daily life, until that ability is altered or taken
away by disease.
TitleOptimal calcium imaging with shaped excitation
Investigator
Liam M Paninski, Darcy S Peterka
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Optimal calcium imaging with shaped excitation
Understanding information flow in the brain is dependent on simultaneously recording the activity
of large neuronal populations.
TitleOptimized dosing of repetitive transcranial magnetic stimulation for enhancement of hippocampal-cortical networks
Investigator
Joel L Voss
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Memory impairment occurs in a variety of neuropsychiatric conditions (e.g., depression and schizophrenia) and
in many neurologic disorders (e.g., neurodegenerative disease and brain injury), often with devastating
consequences for life quality.
TitleOptimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodes
Investigator
Bijan Pesaran, John Rogers, Kenneth L Shepard, Jonathan Viventi
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
In this proposal, we will develop next-generation flexible micro-electrocortigraphic (µECoG) and penetrating
electrode arrays using active electronics in complementary metal-oxide-semiconductor (CMOS) technology.
Active electronics enable amplification and multiplexing directly at each ele
TitleOptimizing peripheral stimulation parameters to modulate the sensorimotor cortex for post-stroke motor recovery
Investigator
Karunesh Ganguly
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Stroke is the leading cause of disability in the United States, with approximately 700,000 new cases per
year. Disability from upper limb impairment depends primarily on loss of hand function and finger
dexterity.
TitleOptogenetic signaling inhibitors for studying brain plasticity
Investigator
Wenbiao Gan, Ryohei Yasuda
Institute
max planck florida corporation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Synaptic plasticity is thought to be a basis of learning and memory of the brain. Signaling
mechanisms underlying synaptic and behavioral plasticity have been extensively studied
with the aid of pharmacological and genetic manipulation of signaling.
TitleQuiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System
Investigator
Angel V Peterchev
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
This project will develop a low-noise transcranial magnetic stimulation (TMS) system. TMS is a technique
for non-invasive brain stimulation using strong, brief magnetic pulses. TMS is widely used as a tool for probing
brain function and is an FDA approved treatment for depression.
TitleRapid Electrode Multiplexing for Scalable Neural Recording
Investigator
Ross M Walker
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Rapid Electrode Multiplexing for Scalable Neural Recording
Large-scale recording of neural signals is essential for gaining a better understanding of the elaborate, dynamic
picture of the brain that emerges from interactions involving individual cells and complex neural circuits.
TitleRational Optimization of tACS for Targeting Thalamo-Cortical Oscillations
Investigator
Flavio Frohlich
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH
The alpha oscillation is a thalamo-cortical rhythm (8-12 Hz) that serves important functional roles in
cognition and behavior.
TitleRealization of Optical Cell-based Reporters for in vivo Detection of Neuropeptides
Investigator
David Kleinfeld, Paul A Slesinger
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuropeptides are essential neuromodulators in the brain.
TitleResting state connectivity: Biophysical basis for and improved fMRI measurements
Investigator
David Kleinfeld, Bruce R Rosen
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Principal Investigators(Last, first, middle):KLEINFELD, DAVID and ROSEN, BRUCE R.
Functional magnetic resonant imaging (fMRI) is the only means to infer neuronal activity within the
entire volume of the human brain.
TitleShort Course in Adaptive Neurotechnologies
Investigator
Gerwin Schalk, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurological disorders affect many millions of people in the United States and throughout the world.
TitleSpatiotemporal control of large neuronal networks using high dimensional optimization
Investigator
Shinung Ching, Jr-Shin Li, Jason T Ritt
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The long terms goal of this project is to enable the control of large networks in the brain using neurostimulation
technologies, a key focus of the BRAIN initiative.
TitleSpatiotemporal signatures of neural activity and neurophysiology in the BOLD signal
Investigator
Shella D Keilholz
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
The blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) fluctuations used to
map functional connectivity contain a wealth of information about neural activity and physiological processes
in the brain.
TitleStructure guided design of photoselectable channelrhodopsins
Investigator
Vadim Cherezov, Samuel Andrew Hires, Vsevolod Katritch, John Yu-Luen Lin
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
This proposal outlines the development of a fundamentally new optogenetic technology capable
of flexibly manipulating the activity of thousands of neurons contributing to the dynamic activity
of distributed neural circuits with single neuron resolution.
No method that currently exis