Speech production and control is disrupted in a number of neurological diseases that involve the basal ganglia.
Notably, hypophonia and hypokinetic dysarthria (characterized by decreased motor gain) are prevalent in
patients with Parkinson's disease (PD).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleSubthalamic and corticosubthalamic coding of speech production
Investigator
Robert Mark Richardson
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
TitleTechnologies for spatiotemporally precise & closed-loop control of selected neurons to prevent epileptic seizures
Investigator
Omar Jamil Ahmed
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Epilepsy is an often debilitating neurological condition affecting 3 million Americans and more than 50 million
people across the globe.
TitleTowards deep brain monitoring with superficial EEG sensors plus neuromodulatory focused ultrasound
Investigator
Pierre D Mourad
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Electrical activity in the brain is a direct correlate to neuronal activity. Existing technology can record
electrical activity on a millisecond scales through invasive placement of electrodes within the brain or non-
invasively, using subdermal electrodes.
TitleUnderstanding evoked and resting-state fMRI through multi scale imaging
Investigator
R Todd Constable, Michael C. Crair, Dewan Syed Fahmeed Hyder
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This RFA is aimed at bringing together interdisciplinary teams to focus on novel, transformative and integrative
efforts that will revolutionize our understanding of the biological and bioinformatics content of the data collected
from non-invasive human functional brain imaging techn
TitleUnderstanding the Neural Basis of Volitional State through Continuous Recordings in Humans
Investigator
Sydney S Cash
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
In the course of a day we naturally make multiple shifts in our overall cognitive state and in our aims and
intents. We go from sleep to awake, from internal dialogue to external communication, from relative immobility
to planned complex movements.
TitleWearable Transcranial Focused Ultrasound System for Region-specific Functional Neuromodulation
Investigator
Seung-Schik Yoo
Institute
brigham and women's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The main objective of the proposed research is to develop a wearable transcranial focused ultrasound
(tFUS) environment that reversibly modulates (either elicits or suppresses) region-specific neural
activities of the brain.
TitleWide deployment of massively multiplexed nanosystems for brain activity mapping
Investigator
Michael L Roukes, Kenneth L Shepard
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
This project will place into the hands of many experimental neuroscientists validated, massively-multiplexed tools
for recording of neuronal activity, for chemical sensing of neuromodulators, and for highly-patterned optogenetic
stimulation with concurrent electrical recording – in any region of the
TitleWireless Photometry For In Vivo Behavorial Studies
Investigator
Paul Braun, Michael R Bruchas
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
The goal of this R21 proposal is to develop a robust, minimally invasive wireless photometry
system for in vivo calcium measures in freely moving behavior.
TitleWireless recording in the central nervous system with ultrasonic neural dust
Investigator
Jose Miguel Carmena
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
We propose an ultra-miniature as well as extremely compliant system that enables massive scaling in the
number of neural recordings from the brain while providing a path towards large-scale neural recordings and
truly chronic brain-machine interfaces (BMI).
TitleA new strategy for cell-type specific gene disruption in flies and mice
Investigator
Thomas Robert Clandinin, Nirao Mahesh Shah
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Developing and validating a toolkit for cell type specific gene manipulation PIs: Clandinin and Shah Neurons express complex arrays of genes that play crucial roles in determining neuronal function.
TitleA novel approach to examine slow synaptic transmission in vivo
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Two primary modes of chemical communication occur between neurons in the brain: fast synaptic transmission, such as that mediated by glutamate and GABA, which directly control the electrical activities of neurons, and slow synaptic transmission, such as tha
TitleA robust ionotropic activator for brain-wide manipulation of neuronal function
Investigator
Andrew D Ellington, Boris V Zemelman
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal embodies the rational design, high throughput screening, and in vitro characterization of novel neuronal actuators. The starting point for our endeavor is an ionotropic channel that launched the optogenetic revolution.
TitleA viral system for light-dependent trapping of activated neurons
Investigator
Michael R Drew, Stephen Martin, Boris V Zemelman
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A central goal in neuroscience is to identify cellular ensembles supporting mental and behavioral states, but these ensembles cannot be defined a priori.
TitleAN INDUCIBLE MOLECULAR MEMORY SYSTEM TO RECORD TRANSIENT STATES OF CNS CELLS
Investigator
Robi D Mitra
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain is a remarkably complex organ comprised of hundreds of unique cell types that are organized to form sophisticated neural circuits.
TitleAnion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals
Investigator
Valentin Dragoi, Roger Janz, John Lee Spudich
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Examining neural circuits crucially relies on the ability to activate or silence individual circuit components to subsequently assess their impact on other parts of the circuit and their influence on behavior.
TitleAnterograde monosynaptic tracing
Investigator
Ian R Wickersham
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Monosynaptic tracing using rabies virus has become a standard component of the systems neuroscience toolkit, allowing identification and manipulation of neurons directly presynaptic to any targeted neuronal population in the brain.
TitleBerkeley Course on Mining and Modeling of Neuroscience Data
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This proposal is to administer and further develop a successfully established two-week summer training course titled "Mining and Modeling of Neuroscience Data" which is held at UC Berkeley.
TitleBiological 'Living Electrodes' Using Tissue Engineered Axonal Tracts to Probe and Modulate the Nervous System
Investigator
Daniel Kacy Cullen
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Brain Machine Interfaces (BMIs) allow the nervous system to directly communicate with external devices in order to mitigate deficits associated with neurodegeneration or to drive peripheral prosthetics.
TitleBRAIN Initiative: Integrated Multimodal Analysis of Cell and Circuit-Specific Processes in Hippocampal Function
Investigator
Jonathan V. Sweedler
Institute
university of illinois at urbana-champaign
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The BRAIN Initiative seeks to understand the spatial, temporal and chemical nature of the brain.
TitleBuilding and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice
Investigator
Peyman Golshani, Baljit Khakh, Dejan Markovic, Alcino J. Silva
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): One of the biggest challenges in neuroscience is to understand how neural circuits in the brain process, encode, store, and retrieve information.