DESCRIPTION (provided by applicant): In this proposal we leverage our recent developments in MRI acquisition methods and new animal models to attempt direct detection of neuronal currents with Magnetic Resonance Imaging (MRI).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCapabilities of MRI-Based Neural Current Imaging for Human Brain Mapping
Investigator
Young R Kim
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
TitleCarbon Thread Arrays for High Resolution Multi-Modal Analysis of Microcircuits
Investigator
Joshua D Berke, Cynthia Anne Chestek
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A major goal in neuroscience is to understand the computations performed by local brain circuits. A large obstacle to achieving this goal is that - at least in mammals - we currently cannot observe the spiking activity of most neurons within a circuit.
TitleCentral thalamic stimulation for traumatic brain injury
Investigator
Christopher R Butson, Joseph Thomas Giacino, Jaimie M Henderson, Andre Guelman Machado, Nicholas D Schiff
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Severe to moderate traumatic brain injury (smTBI) annually afflicts many hundreds of thousands of Americans producing chronic cognitive disabilities that lack effective treatments.
TitleComputational and circuit mechanisms for information transmission in the brain
Investigator
Uri Tzvi Eden, Loren M Frank, Surya Ganguli, Adam Kepecs, Mark Alan Kramer, Christian Machens, Vanessa Tolosa
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain is a massively interconnected network of regions, each of which contains neural circuits that process information related to combinations of sensory, motor and internal variables.
TitleConducting polymer nanowires for neural modulation
Investigator
Christine K Payne
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Understanding how people think, act, and feel ultimately requires understanding how neural circuits interact spatially and temporally. This level
of understanding requires fundamentally new tools that are high-throughput, direct, and non-invasive.
TitleCoSMo - Summer School in Computational Sensory-Motor Neuroscience
Investigator
Paul R Schrater
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research.
TitleDevelopment of a scalable methodology for imaging neuropeptide release in the brain
Investigator
David J Anderson
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A common metaphor to describe the brain is that it is like a supercomputer. Consequently, current efforts at improving technologies for large-scale recording of brain function are primarily focused on measuring its electrical activity.
TitleDynamic network computations for foraging in an uncertain environment
Investigator
Dora Angelaki, Valentin Dragoi, Zachary Samuel Pitkow, Paul R Schrater
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain evolved complex recurrent networks to enable flexible behavior in a dynamic and uncertain world, but its computational strategies and underlying mechanisms remain poorly understood.
TitleEmploying subcellular calcium to control membrane voltage
Investigator
Ute H Hochgeschwender, Diane Lipscombe, Christopher I Moore
Institute
central michigan university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of this proposal is to assess the feasibility of an all-molecular method for activity-dependent feedback control of neuronal activity.
TitleEngineered viral tropism for cell-type specific manipulation of neuronal circuits
Investigator
Daniel Schmidt, Mark John Thomas
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): It is a longstanding goal in neuroscience to reveal how specific cell types contribute to different neural circuits that underlie cognition, behavior, and disease pathology.
TitleFive-dimensional optoacoustic tomography for large-scale electrophysiology in scattering brains
Investigator
Daniel Razansky
Institute
technical university of munich
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuroscience has an essential requirement for large-scale neural recording technologies to ensure rapid progress in the understanding of brain function, diagnosis and treatment of neurological disorders.
TitleFluorescent Sensors for Imaging External Potassium in the Brain
Investigator
William R Kobertz
Institute
univ of massachusetts med sch worcester
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of this project is fluorescently visualize potassium (K+) egress and extracellular accumulation at the cell surface.
TitleGenerating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability
Investigator
Zhigang He
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The ability to examine the connectivity and functions of specific brain nuclei and specific neuron types is critical for understanding how the brain works at both microcircuit and mesoscale levels.
TitleGenetic tools and imaging technology for mapping cholinergic engrams of anxiety
Investigator
Lorna W Role
Institute
state university new york stony brook
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This application will develop new genetic tools and advance current procedures for precise and rapid mapping of behavior specific memory engrams.
TitleHigh resolution deep tissue calcium imaging with large field of view wavefront correction
Investigator
Meng Cui, Wenbiao Gan
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): High resolution deep tissue calcium imaging with large field of view wavefront correction Two-photon microscopy based calcium imaging allows in vivo observation of neuronal dynamics at high spatial and temporal resolutions.
TitleHigh resolution electrical brain mapping by real-time and portable 4D Acoustoelectric Imaging
Investigator
Russell S Witte
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Our vision is to develop the first noninvasive, real-time and portable electrical brain mapping system based on disruptive acoustoelectric (AE) technology.
TitleHigh-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording
Investigator
Leigh R Hochberg, Arto Nurmikko
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurologic disorders including cervical spinal cord injury, brainstem stroke, and amyotrophic lateral sclerosis can lead to severe paralysis of all fou limbs.
TitleHigh-speed Deep Brain Imaging and Modulation with Ultrathin Minimally Invasive Probes
Investigator
Rafael Piestun
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): An understanding of the neural mechanisms and computational principles of the human brain requires the study of non-human primates (NHP) in addition to small animals.
TitleHigh-speed volumetric imaging of neuronal network activity at depth using Multiplexed Scanned Temporal Focusing (MuST)
Investigator
Alipasha Vaziri
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): We propose to design and build a device that will push the boundaries of existing technology for imaging the activity of large-scale neuronal networks at high speed and single cell resolution.
TitleImplantable Brain Microelectromechanical Magnetic Sensing and Stimulation (MEMS-MAGSS)
Investigator
Steven J Schiff, Srinivas Tadigadapa
Institute
pennsylvania state univ hershey med ctr
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This NIH BRAIN Initiative R21 will initiate development of a completely Implantable Brain Microelectromechanical Magnetic Sensing and Stimulation (MEMS-MAGSS) technology.