DESCRIPTION (provided by applicant): Truly integrative and interdisciplinary training in neuroscience is necessary to understand brain function in both normal and pathological states.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleInterdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
Investigator
Satish S Nair
Institute
university of missouri-columbia
Fiscal Year
Funding Opportunities Number
Project Number
TitleIntrabody-dependent activation of cell-specific gene expression in CNS
Investigator
Seth Blackshaw
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The mammalian central nervous system (CNS) contains many hundreds of molecularly and functionally distinct cell types, which comprise the basic building blocks of neural circuitry.
TitleLabel-free 4D optical detection of neural activity
Investigator
Maksim V Bazhenov, Devin K Binder, Boris Hyle Park
Institute
university of california riverside
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The ideal neuroimaging technique would provide exquisite structural detail and also provide functional information, with high spatial and temporal
resolution.
TitleLagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor Sequences
Investigator
Ryan Prescott Adams, Sandeep R Datta, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Behaviors are sequences of actions that are executed in the proper order and correct setting to achieve a goal.
TitleLIPS: A novel technology for spatial and temporal control of protein synthesis in dendritic spines
Investigator
Wenbiao Gan, Samie R Jaffrey
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The proteins in synapses are the fundamental regulators of synaptic plasticity, which ultimately controls the neural circuits that underlie behavior.
TitleLOCATER: Large-scale Observation of Cellular Activity Through Exosomal Reporters
Investigator
Feng Zhang
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Electrophysiology and fluorescent imaging are widely used to study neural activity in vivo.
TitleMassive scale electrical neural recordings in vivo using commercial ROIC chips
Investigator
Konrad P. Kording, Andreas Schaefer
Institute
rehabilitation institute of chicago d/b/a shirley ryan abilitylab
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Current scaling behavior in electrical recording is dominated by the difficulty of fabricating systems with many high bandwidth channels.
TitleMultiplexed Multiphoton Interrogation of Brain Connectomics
Investigator
Xue Han, Siddharth Ramachandran
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Multiphoton laser scanning microscopy has revolutionized neuroscience since it is less invasive than traditional electrophysiology methods for probing neuronal processes.
TitleMULTISCALE ANALYSIS OF SENSORY-MOTOR CORTICAL GATING IN BEHAVING MICE
Investigator
Dieter Jaeger, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): To address the core question underlying the Obama Brain Initiative to better understand the function of complex brain circuits, we propose a multi-scale recording and data analysis project to study the dynamical interactions between sensory cortex, motor cor
TitleMultiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and Function
Investigator
R Todd Constable, Michael C. Crair
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The purpose of this RFA is to promote the integration of experimental, analytic and theoretical capabilities for the examination of neural circuits and systems.
TitleNetwork basis of action selection
Investigator
Anatol Kreitzer, Takaki Komiyama, Byungkook Lim
Institute
j. david gladstone institutes
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The anatomical substrates and cellular mechanisms underlying reward-dependent learning have been studied for decades, but the specific circuit and network interactions between the cortex, striatum, and midbrain that mediate action selection have not been sys
TitleNeural ensembles underlying natural tracking behavior
Investigator
Ila R. Fiete, Alexander C Huk, Nicholas J Priebe
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The system that controls smooth pursuit eye movements is one of the most accessible, promising systems for understanding how neural circuits transform sensory inputs into actions.
TitleNeural Monitoring with Magnetically-Focused Electrical Impedance Tomography (mf-EIT)
Investigator
Daniel Kenneth Freeman
Institute
charles stark draper laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): There is a great need in clinical neuroscience for improved methods of non-invasively monitoring brain activity.
TitleNeuron selective modulation of brain circuitry in non-human primates
Investigator
Charles F Caskey, Li Min Chen, William A Grissom
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for brain circuit investigation.
TitleNeuronal voltage tracers for photoacoustic imaging in the deep brain
Investigator
Jon Thomas Sack
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The overarching goal of this project is to develop molecular tracers for imaging neuronal voltage changes deep in the brain.
TitleNeurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
Investigator
Gregory A Worrell
Institute
mayo clinic rochester
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Approximately 1/3 of people living with epilepsy (PWE) continue to have seizures despite anti-epileptic drugs (AEDs). Recent trials using therapeutic brain stimulation show reductions in seizures, but rarely provide seizure free outcomes.
TitleNon-degenerate multiphoton microscopy for deep brain imaging
Investigator
Anna Devor, Yeshaiahu L Fainman
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The overarching goal of this proposal is to push the depth penetration of multiphoton microscopy targeting neuroscience applications in need of large-scale recording of cortical activity where high resolution requirement (in the order of singl microns) cann
TitleNorthern Lights collaboration for better 2-photon probes
Investigator
Robert E. Campbell, Nathan G Clack, Mikhail Drobizhev, Thomas E Hughes
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The Northern Lights collaboration for better 2-photon probes will combine the expertise of four very different investigators and laboratories from Montana and Canada with complementary interests and skills to tackle a fundamental problem in imaging of the a
TitleNovel optrodes for large-scale electrophysiology and site-specific stimulation
Investigator
John Assad, Luca Berdondini, Massimo Devittorio, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brains of mammals contain an extraordinarily large number of neurons whose activity and interconnections determine the function of circuits that monitor our sensory environment, dictate our motor choices, form memories, and guide all behavior.
TitleNovel tools for cell-specific imaging of functional connectivity and circuit operations
Investigator
Ehud Isacoff
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Fundamental to understanding brain function is the ability to relate the spatio-temporal firing patterns of specific neurons to their functional connectivity and determine the strength and experience-dependent regulation of those connections.